Abstract：
:We studied the effect of turmeric extract in the composition of rectal suppositories on the level of LPO products and oxidative modification of proteins in the colon mucosa of Wistar rats with experimental Crohn's disease modeled by rectal administration of trinitrobenzenesulfonic acid. The suppositories containing turmeric extract were administered 12 h after disease induction. On days 3, 5, and 7 of the experiment, clinical parameters of the disease were scored using disease activity scale (DAI) and the concentration of LPO products and intensity of oxidative modification of proteins were measured by the extraction-spectrofluorimetric method. Administration turmeric extract in rectal suppositories reduced the severity of clinical symptoms, the level of LPO products (mostly in the isopropanol phase of the lipid extract), and the total content of products of oxidative modification of proteins. Moreover, correlations between DAI and concentration of LPO products in the colon were found.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Osikov MV,Simonyan EV,Bakeeva AE,Ogneeva OIdoi
10.1007/s10517-020-04883-wsubject
Has Abstractpub_date
2020-07-01 00:00:00pages
342-346issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-020-04883-wjournal_volume
169pub_type
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