Changes in the cytokine profile and reduced function of lymphocyte subpopulations in subacute tetrachloromethane poisoning.

Abstract:

:Experiments on outbred albino rats showed that subacute poisoning with tetrachloromethane in a total dose of 1.0 LD50 appreciably decreased blood concentrations of cytokines (IFN-gamma, IL-2, IL-4, IL-6, IL-10), reduced the IFN-gamma/IL-4 ratio in comparison with the control, and suppressed the immune reactions, which attests to greater damage to Th1 compared to Th2 lymphocytes.

journal_name

Bull Exp Biol Med

authors

Zabrodskii PF,Kirichuk VF,Lim VG,Balashov SV,Svistunov AA

doi

10.1007/s10517-009-0449-7

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

52-4

issue

1

eissn

0007-4888

issn

1573-8221

journal_volume

147

pub_type

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