Epidermocyte nuclear-nucleolar system in atopic dermatitis and lichen planus.

abstract：:Hepatoprotective activity of pyrimidine derivative hydroxymethyluracil was studied on the model of acute paracetamol-induced liver damage in rats. Hydroxymethyluracil was shown to produce a strong hepatoprotective effect. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mirsaev TR

更新日期：2007-05-01 00:00:00

abstract：:Location of cathepsin D and elastase in rat uterus was studied by electron-histochemical method. Activities of both proteinases in the myometrium was detected in lysosomes of smooth-muscle cells, macrophages, and fibroblasts. ...

journal_title：Bulletin of experimental biology and medicine

authors： Ryvnyak VV,Gudumak VS,Dulgieru OF

更新日期：2003-08-01 00:00:00

abstract：:We studied processes of proliferation and differentiation of hemopoietic precursor cells in mice treated with granulocyte CSF under conditions of cytostatic myelodepression. It was found that the hemostimulating effect of original granulocyte CSF preparation consists in accelerated maturation of hemopoietic precursors...

journal_title：Bulletin of experimental biology and medicine

authors： Goldberg ED,Dygai AM,Zhdanov VV,Guryantseva LA,Udut EV,Popova NO,Simanina EV,Khrichkova TY

更新日期：2005-01-01 00:00:00

abstract：:GABA, baclofen, isoguvacine increase, and cis-4-aminocrotonic acid does not modify resting membrane potential of muscle cells. Bicuculline, phaclofen, N-ethylmaleimide, chlorpromazine, verapamil, and removal of Ca2+ from bathing solution abolished the effect of baclofen, while U73122 and D609 were ineffective in this ...

journal_title：Bulletin of experimental biology and medicine

authors： Volkov EM,Sabirova AR,Grishin SN,Zefirov AL

更新日期：2005-02-01 00:00:00

abstract：:Model experiments on biomicroscopy of mesenteric microvessels in laboratory rats were performed to evaluate the effect of natural metabolites (e.g., amino acid glycine) on the microcirculation. The effect of glycine was determined from a change in the diameter of arterioles. Application of glycine (0.1 ml, 1 M) to the...

journal_title：Bulletin of experimental biology and medicine

authors： Podoprigora GI,Nartsissov YR

更新日期：2009-03-01 00:00:00

abstract：:Olfactory ensheathing cells showed significant effects on the regeneration of the spinal cord in experimental models and in clinical trials. However, the use of these cells in the therapy of posttraumatic cysts of the spinal cord has not been studied. Cultures of human and rat olfactory mucosa were obtained according ...

journal_title：Bulletin of experimental biology and medicine

authors： Voronova АD,Stepanova OV,Valikhov MP,Chadin AV,Semkina АS,Abakumov MA,Reshetov IV,Chekhonin VP

更新日期：2019-08-01 00:00:00

abstract：:We developed a cytochrome P450 substrate-inhibitor panel for preclinical in vitro evaluation of drugs in a 3D histotypical microfluidic cell model of human liver (liver-on-a-chip technology). The concentrations of substrates and inhibitors were optimized to ensure reliable detection of the principal metabolites by HPL...

journal_title：Bulletin of experimental biology and medicine

authors： Zakhariants AA,Burmistrova OA,Shkurnikov MY,Poloznikov AA,Sakharov DA

更新日期：2016-11-01 00:00:00

abstract：:We studied the influence of high-fat diet on the development of metabolic syndrome in rats of hypertensive ISIAH strain and normotensive WAG strain. In contrast to ISIAH rats, high-fat diet in WAG rats led visceral obesity, glucose tolerance, and dyslipidemia. DNA-binding activity of the peroxisome proliferator-activa...

journal_title：Bulletin of experimental biology and medicine

authors： Dushkin MI,Khrapova MV,Kovshik GG,Chasovskikh MI,Selyatitskaya VG,Palchikova NA

更新日期：2014-03-01 00:00:00

abstract：:The content of urokinase- and tissue-type plasminogen activators and plasminogen activator inhibitor PAI-1 in the cytosol of primary and metastatic melanomas and benign skin pigment neoplasms was estimated by enzyme immunoassay. It was shown that local growth and invasion of melanomas are related to suppressed express...

journal_title：Bulletin of experimental biology and medicine

authors： Gershtein ES,Medvedeva SV,Babkina IV,Kushlinskii NE,Trapeznikov NN

更新日期：2001-07-01 00:00:00

abstract：:The interaction between recombinant soluble CD4 receptor (rsCD4) with human apolipoprotein A-I was studied by enzyme-linked immunosorbent assay. Our findings suggest that HIV-1 and human apolipoprotein A-I compete for the CD4 receptor and receptor for apoA-I. ...

journal_title：Bulletin of experimental biology and medicine

authors： Panin LE,Kostina NE

更新日期：2002-04-01 00:00:00

abstract：:Effects of low-intensity microwave radiation with bioactive frequency were studied in rats with transplanted sarcoma 45. After exposure to microwave radiation in the regimen of activation therapy, the antitumor effect was observed in 50% animals (marked inhibition of tumor growth or its partial regression). Light and ...

journal_title：Bulletin of experimental biology and medicine

authors： Gudzkova TN,Zhukova GV,Garkavi LH,Sukhanova MI,Evstratova OF,Barteneva TA

更新日期：2011-03-01 00:00:00

abstract：:The mechanisms of therapeutic resistance of human glioblastoma multiforme are analyzed. The authors make an attempt at systematization and scientific theoretical validation of new approaches to creation of biomedical cellular preparations, based on the oncoproteomic technologies, for personified therapy of the glial t...

journal_title：Bulletin of experimental biology and medicine

authors： Bryukhovetskii IS,Bryukhovetskii AS,Khotimchenko YS

更新日期：2015-04-01 00:00:00

abstract：:Non-clonal and clonal abnormal cells (hypodiploid, polyploid, and with chromosome aberrations) were detected by the G-method in the bone marrow and blood of the majority of patients with non-Hodgkin lymphomas before therapy. The manifestation of these abnormalities changed individually after treatment. The most incide...

journal_title：Bulletin of experimental biology and medicine

authors： Ankina MA,Zavitaeva TA,Panferova TA,Shakhtarina SV,Pavlov VV

更新日期：2007-02-01 00:00:00

abstract：:Human umbilical cord represents a source of multipotent stromal cells of a supreme therapeutic potential. The cells can be isolated from either fresh or cryopreserved umbilical cord tissues. DMSO is a cryoprotectant most commonly used for preservation of umbilical cord tissues; however, cyto- and genotoxicity of this ...

journal_title：Bulletin of experimental biology and medicine

authors： Arutyunyan IV,Strokova SО,Makarov АV,Mullabaeva SМ,Elchaninov АV,Lokhonina АV,Abramov АА,Fatkhudinov ТK

更新日期：2018-11-01 00:00:00

abstract：:The cytotoxic effects of human blood serum were studied under normal and pathological conditions. The contribution of the complement system to the realization of this effect was demonstrated. Significant differences in the serum capacity to kill foreign cells were detected for healthy subjects and asthmatics. Bovine s...

journal_title：Bulletin of experimental biology and medicine

authors： Arkhipova EN,Cherepov AB,Medvedeva YS,Alchinova IB,Karganov MY

更新日期：2012-09-01 00:00:00

abstract：:Polylactide degradation processes after its implantation into the subcutaneous fat of rats were studied by microscopy. After implantation polylactide was encapsulated in connective tissue. If a fragment of polylactide had sharp edges, injuring the tissue, a thick capsule formed with pronounced inflammatory infiltratio...

journal_title：Bulletin of experimental biology and medicine

authors： Maiborodin IV,Kuznetsova IV,Beregovoi EA,Shevela AI,Barannik MI,Maiborodina VI,Manaev AA

更新日期：2014-04-01 00:00:00

abstract：:Myocardial remodeling in SHR rats with age-related hypertrophy was characterized by elimination of cardiomyocytes, their hypertrophy, and marked increase in the volume of the connective tissue. The count of cardiomyocytes with contracture injuries and subsegmental contractures increased, and pronounced perivascular an...

journal_title：Bulletin of experimental biology and medicine

authors： Lushnikova EL,Nepomnyashchikh LM

更新日期：2003-02-01 00:00:00

abstract：:Phenibut and its derivatives normalized cellular (index of delayed-type hypersensitivity reaction) and humoral (antierythrocyte antibody titer) immunity and the lymphoproliferative processes in immunocompetent organs of animals with cyclophosphamide-induced immunosuppression. This indicates pronounced immunocorrective...

journal_title：Bulletin of experimental biology and medicine

authors： Tyurenkov IN,Samotrueva MA

更新日期：2009-05-01 00:00:00

abstract：:We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in...

journal_title：Bulletin of experimental biology and medicine

authors： Litvinova SV,Aristova VV,Shul'govskii VV,Basharova LA,Terebilina NN,Panchenko LF

更新日期：2001-01-01 00:00:00

abstract：:Enzyme immunoassays showed significantly elevated content of matrix metalloproteinase 7 and type 1 tissue inhibitor of metalloproteinases in tumors compared to adjacent histologically unchanged mucosa of patients with colorectal cancer; the levels of metalloproteinase 9 and type 4 tissue inhibitor of metalloproteinase...

journal_title：Bulletin of experimental biology and medicine

authors： Gershtein ES,Korotkova EA,Shcherbakov AM,Prorokov VV,Golovkov DA,Kushlinskii NE

更新日期：2007-04-01 00:00:00

abstract：:We studied morphological changes in rat abdominal aorta and vena cava inferior induced by endovascular microwave destruction. This treatment induced thrombosis and necrosis of the vascular walls, but fibrous framework was not completely destroyed. Then we observed irreversible changes in vessels: obliteration, atrophy...

journal_title：Bulletin of experimental biology and medicine

authors： Denisov-Nikol'skii YI,Shafranov VV,Borkhunova EN,Doktorov AA,Mikhaleva LM,Mikhalev AP

更新日期：2002-07-01 00:00:00

abstract：:A combination of electrochemical lysis and photodynamic therapy were used to attain complete resorption of M-1 sarcoma in rats; both treatment modalities were used with minimum parameters. Fotolon served as the photosensitizer for photodynamic therapy. Accumulation of the sensitizer in the tumor and normal tissue was ...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhailovskaya AA,Kaplan MA,Brodskij RA,Bandurko LN

更新日期：2009-01-01 00:00:00

abstract：:The parameters of thermal dependence of H+ transport into human erythrocytes in the presence of furosemide were measured. The relationship between these changes and function of band 3 protein of the erythrocyte membrane is discussed. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mishchenko AA,Irzhak LI

更新日期：2004-07-01 00:00:00

abstract：:The cardioprotective effects of Ganoderma lucidum extract were examined in experiments with global ischemia (45 min) and reperfusion (30 min) of isolated and perfused rat heart. The course of preventive administration of the extract in a dose of 400 mg/kg for 15 days diminished necrotic death of cardiomyocytes and red...

journal_title：Bulletin of experimental biology and medicine

authors： Lasukova TV,Maslov LN,Arbuzov AG,Burkova VN,Inisheva LI

更新日期：2015-04-01 00:00:00

abstract：:We studied the effect of vasopressin analogue desglycinamide-arginine-vasopressin on changes in platelet hemostasis produced by intragastric administration of Ticlid or clopidogrel (inhibitors of ADP-induced platelet aggregation). Intranasal administration of the peptide under conditions of hemorrhagic diathesis produ...

journal_title：Bulletin of experimental biology and medicine

authors： Golubeva MG,Grigoreva ME,Smirnova MP

更新日期：2005-08-01 00:00:00

abstract：:An important role in the development of the immune response is played by macrophages that acquire either anti-inflammatory M1 or anti-inflammatory M2 phenotype depending on their microenvironment. The possibility of targeted reprogramming of the initial M2 macrophage phenotype towards M1 phenotype and vice versa using...

journal_title：Bulletin of experimental biology and medicine

authors： Lyamina SV,Kruglov SV,Vedenikin TY,Borodovitsyna OA,Suvorova IA,Shimshelashvili ShL,Malyshev IY

更新日期：2012-02-01 00:00:00

abstract：:Influenza virus hemagglutinins are surface proteins responsible for fusion of the viral and cellular membranes. Their capacity to mediate membrane fusion (fusogenic activity) is studied by various methods, including the syncytium formation and pseudovirus transduction methods. We constructed plasmids coding for genes ...

journal_title：Bulletin of experimental biology and medicine

authors： Kononova AA,Cheresiz SV,Chechushkov AV,Razumova YV,Pokrovskii AG

更新日期：2017-11-01 00:00:00

abstract：:We studied the possibility of reproducing syringomyelia in rabbits by injection of serum from patients with syringomyelia. Clinical signs of syringomyelia and morphological changes in the central nervous system (cavities, dilatation of the cerebrospinal channel, neurodegeneration, gliosis) developed in laboratory anim...

journal_title：Bulletin of experimental biology and medicine

authors： Mirsayev TR,Borisova NA

更新日期：2007-04-01 00:00:00

abstract：:Isolated rat hearts were subjected to 30-min coronary artery occlusion followed by 120-min reperfusion. The hearts (n=8-12) were perfused with Krebs-Henseleit solution enriched with L-carnitine (0.5, 2.5 and 5 mM) for 10 min before and after ischemia or reperfusion and for the whole period of ischemia and reperfusion....

journal_title：Bulletin of experimental biology and medicine

authors： Najafi M,Garjani A,Maleki N,Eteraf Oskouei T

更新日期：2008-08-01 00:00:00

abstract：:Moderate hypothermia stimulates LPO processes in rat plasma and erythrocytes and simultaneously increases antioxidant activity in the plasma and SOD activity erythrocyte. Dalargin prevents stimulation of LPO in the blood in hypothermia by reducing the generation of active oxygen species and maintaining the level of lo...

journal_title：Bulletin of experimental biology and medicine

authors： Tadzhibova LT,Astaeva MD,Ismailova JG,Daudova TN,Klichkhanov NK

更新日期：2011-01-01 00:00:00