Abstract：
:We studied the influence of high-fat diet on the development of metabolic syndrome in rats of hypertensive ISIAH strain and normotensive WAG strain. In contrast to ISIAH rats, high-fat diet in WAG rats led visceral obesity, glucose tolerance, and dyslipidemia. DNA-binding activity of the peroxisome proliferator-activated receptor α (PPARα) decreased in the liver of WAG rats and increased in ISIAH rats. Blood levels of TNF-α, IL-6, and corticosterone increased more significantly in WAG rats. Corticosterone content in the adrenal glands was more markedly reduced in WAG rats. High-fat diet had no effect on BP in ISIAH and WAG rats. It was concluded that ISIAH rats can be used as a genetic model in studies of the mechanism of resistance to the metabolic syndrome.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Dushkin MI,Khrapova MV,Kovshik GG,Chasovskikh MI,Selyatitskaya VG,Palchikova NAdoi
10.1007/s10517-014-2417-0subject
Has Abstractpub_date
2014-03-01 00:00:00pages
649-53issue
5eissn
0007-4888issn
1573-8221journal_volume
156pub_type
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