Abstract：
:Polylactide degradation processes after its implantation into the subcutaneous fat of rats were studied by microscopy. After implantation polylactide was encapsulated in connective tissue. If a fragment of polylactide had sharp edges, injuring the tissue, a thick capsule formed with pronounced inflammatory infiltration and sclerosis of adjacent tissues. If the implant had no sharp edges, the capsule was thin and the level of inflammation the minimum. Foreign body giant cells were found in the capsule and near it in all cases. The activity of the inflammatory process gradually reduced over 6 months. The intensity of inflammation sharply increased by the 12th month after implantation, when activity of phagocyte enzyme and deformation by the capsule led to fragmentation or liquefaction of polylactide.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Maiborodin IV,Kuznetsova IV,Beregovoi EA,Shevela AI,Barannik MI,Maiborodina VI,Manaev AAdoi
10.1007/s10517-014-2473-5subject
Has Abstractpub_date
2014-04-01 00:00:00pages
874-9issue
6eissn
0007-4888issn
1573-8221journal_volume
156pub_type
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