Development of a Specific Substrate-Inhibitor Panel (Liver-on-a-Chip) for Evaluation of Cytochrome P450 Activity.

abstract：:We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29) in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbo...

journal_title：Bulletin of experimental biology and medicine

authors： Taskaeva YS,Bgatova NP,Dossymbekova RS,Solovieva AO,Miroshnichenko SM,Sharipov KO,Tungushbaeva ZB

更新日期：2020-12-01 00:00:00

abstract：:We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress). Stress exposure of animals for 30 days was followed by a decrease in the relati...

journal_title：Bulletin of experimental biology and medicine

authors： Tallerova AV,Kovalenko LP,Kuznetsova OS,Durnev AD,Seredenin SB

更新日期：2014-01-01 00:00:00

abstract：:Changes in blood pressure and sympathetic nerve activity induced by local injection of endothelin-1 into the rostroventrolateral medulla were studied in narcotized stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive WKY rats. Endothelin-1 produced similar biphasic response in both rat strains: a tran...

journal_title：Bulletin of experimental biology and medicine

authors： Ponomareva TI,Khokhlova ON,Tukhovskaya EA,Murashov AM

更新日期：2003-03-01 00:00:00

abstract：:We analyzed the concentration of extracellular DNA and its fractions in the dynamics of uncomplicated pregnancy Thirty women with singleton pregnancy were examined. The concentration of total, maternal, and fetal cell-free DNA in maternal blood was measured at gestation weeks 11-14, 24-26, and 30-32. The level of tota...

journal_title：Bulletin of experimental biology and medicine

authors： Karapetyan АО,Baev ОR,Krasnyi АМ,Sadekova АА,Мullabaeva SМ

更新日期：2018-11-01 00:00:00

abstract：:Carnosine significantly increased the number of spermatogonia and Sertoli cells in mice prone (SAMP1) and resistant (SAMR1) to accelerated aging and appreciably reduced cell yield in meiosis and spermiogenesis in SAMP1 mice. In experimental SAMP1 mice catastrophic changes in the number of gametes were paralleled by in...

journal_title：Bulletin of experimental biology and medicine

authors： Gopko AV,Kulibin AY,Semenova ML,Zakhidov ST

更新日期：2005-08-01 00:00:00

abstract：:Changes in the diurnal light cycle affect the morphofunctional state of the pineal gland. The volume of the nucleus, Golgi apparatus, and mitochondria in pinealocytes decreases after 45-day exposure to bright light. After 90 days, the degree of nuclear polymorphism increased, the specific volume of the Golgi apparatus...

journal_title：Bulletin of experimental biology and medicine

authors： Gerasimov AV,Logvinov SV,Kostyuchenko VP

更新日期：2010-12-01 00:00:00

abstract：:The effects of photostimulation with different colors on α-rhythm amplitude and parameters of variation pulsometry were studied. Green color stimulation modulates human functions: ?-rhythm amplitude increases by 1.06 μV/√Hz (p<0.05) and the index of regulatory systems strain decreases significantly (p<0.05). ...

journal_title：Bulletin of experimental biology and medicine

authors： Osipova MA,Arkov VV,Tonevitsky AG

更新日期：2010-11-01 00:00:00

abstract：:We studied the effect of vasopressin analogue desglycinamide-arginine-vasopressin on changes in platelet hemostasis produced by intragastric administration of Ticlid or clopidogrel (inhibitors of ADP-induced platelet aggregation). Intranasal administration of the peptide under conditions of hemorrhagic diathesis produ...

journal_title：Bulletin of experimental biology and medicine

authors： Golubeva MG,Grigoreva ME,Smirnova MP

更新日期：2005-08-01 00:00:00

abstract：:The immunolocalization of apoptotic factors in rat neocortex was studied on the model of permanent occlusion of the middle cerebral artery with administration of exogenous BDNF. We revealed heterogeneous distribution of pro- and anti-apoptotic factors in the stroke area and in the surrounding penumbra, where caspase-3...

journal_title：Bulletin of experimental biology and medicine

authors： Kalinichenko SG,Matveeva NY,Korobtsov AV

更新日期：2020-09-01 00:00:00

abstract：:Pronounced changes in the capillaries, hemodynamic disorders, epitheliocyte degeneration and atrophy develop in the buccal mucosa of patients with types I and II diabetes mellitus in the absence of inflammatory cellular infiltration or with facultative infiltration. The morphogenesis of pathological changes can be reg...

journal_title：Bulletin of experimental biology and medicine

authors： Balakhonov LV,Nepomnyashchikh LM,Aidagulova SV,Bakarev MA,Vlasova LF

更新日期：2006-11-01 00:00:00

abstract：:An increase of total glucagon-like peptide-1 (GLP-1) concentration in the plasma in rats was revealed 5 min after oral, but not intraperitoneal administration of NaCl or Trizma HCl solutions. The increase in GLP-1 level was similar to that after oral glucose administration. After intraperitoneal administration of 2.5%...

journal_title：Bulletin of experimental biology and medicine

authors： Marina AS,Kutina AV,Shakhmatoba EI,Natochin YV

更新日期：2017-02-01 00:00:00

abstract：:Immunosorbent removing beta2-microglobulin from human blood plasma was synthesized on the basis of sheep monospecific polyclonal antibodies to beta2-microglobulin and conditions ensuring effective regeneration of the immunosorbent for its repeated use were selected. Relationships between adsorption capacity and the vo...

journal_title：Bulletin of experimental biology and medicine

authors： Shabunina IV,Afanas'eva OI,Pokrovskii SN

更新日期：2001-10-01 00:00:00

abstract：:The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopami...

journal_title：Bulletin of experimental biology and medicine

authors： Chekhonin VP,Baklaushev VP,Kogan BM,Savchenko EA,Lebedev SV,Man'kovskaya IV,Filatova TS,Yusupova IU,Dmitrieva TB

更新日期：2000-08-01 00:00:00

abstract：:Voltage clamp and concentration jump experiments performed on Purkinje cells isolated from rat cerebellum showed that novel imidazobenzoimidazole derivative RU-353 increased the amplitude of GABA-activated chlorine current in a dose-dependent manner (EC50=15 microM for the currents activated by 1 microM GABA). RU-353 ...

journal_title：Bulletin of experimental biology and medicine

authors： Sharonova NI,Vorob'ev VS,Skrebitskii VG,Galenko-Yaroshevskii AP,Turovaya AY,Anisimova VA

更新日期：2005-09-01 00:00:00

abstract：:Structural characteristics of the visual cortex area 17 were studied by computer morphometry on autopsied specimens of the brain from children with perinatal injury to the central nervous system and in a group of control children without symptoms of brain injury. In children with perinatal pathology, the thickness of ...

journal_title：Bulletin of experimental biology and medicine

authors： Sal'kov VN,Khudoerkov RM

更新日期：2007-06-01 00:00:00

abstract：:Paclitaxel in a single MTD of 40 mg/kg caused chromosome aberrations and genome changes (polyploidy) in the bone marrow cells of mice early and 3 months after the injection. The quantity of early precursors of erythropoiesis in the bone marrow decreased, as did their proliferative potential irrespective of the animal ...

journal_title：Bulletin of experimental biology and medicine

authors： Neupokoeva OV,Fedorova EP,Stavrova LA,Voronova OL,Sandrikina LA,Filonova MV,Churin AA

更新日期：2020-05-01 00:00:00

abstract：:The safety of combined administration of ultralow doses of antigens to endothelial NO synthase (impaza) and nitrates for the treatment of erectile dysfunction in CHD patients was evaluated in an open non-comparative clinical trial. The efficiency and safety of impaza and the possibility of its administration to patien...

journal_title：Bulletin of experimental biology and medicine

authors： Zhavbert ES,Kachanova MV,Tarasov SA,Dugina YL,Sergeeva SA,Dovgalevskii PY,Epshtein OI

更新日期：2009-08-01 00:00:00

abstract：:We present a method of minimally invasive transcutaneous insertion of screws using a prefabricated extracorporeal navigation system using additive technologies (based on primary data obtained from the DICOM package in multi-detector computed tomography of the affected spine segment) according to the principle of perso...

journal_title：Bulletin of experimental biology and medicine

authors： Dotsenko IA,Kotomtsev VV,Medvinsky ID,Chertkov AK,Saveliev AV

更新日期：2020-04-01 00:00:00

abstract：:The intensity of calcium and phosphate accumulation in regenerating bone tissue decreased significantly during the posttraumatic period in 54 male CBA mice with acute hepatic intoxication. The formation of organic components of the bone decreased to a lesser degree. Creatine metabolism in the muscles of damaged segmen...

journal_title：Bulletin of experimental biology and medicine

authors： Stogov MV,Luniova SN,Tkachuk EA

更新日期：2010-10-01 00:00:00

abstract：:The expression of synaptophysin (vesicular protein) and mGluR5 (metabotropic glutamate receptor) genes was studied 3, 7, and 20 days after cainic acid injury of the dorsal hippocampal area in Wistar rats. The expression of both genes was characteristically reduced in the hippocampus. Twenty days after the exposure the...

journal_title：Bulletin of experimental biology and medicine

authors： Lebedev DS,Arkhipov VI

更新日期：2009-02-01 00:00:00

abstract：:Intraperitoneal injections of hexavalent chromium (sodium bichromate) in the concentrations of 0.025 μg/kg (10-fold lower than MAC; group 1) and 2.5 μg/kg (10-fold higher than MAC; group 2) to rats in a subacute experiment caused dose-dependent morphological changes in the thymus: increased the counts of cells in a st...

journal_title：Bulletin of experimental biology and medicine

authors： Zhumabaeva AN,Zarishnyak NV,Bekmukhambetov EZh

更新日期：2014-02-01 00:00:00

abstract：:We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene ...

journal_title：Bulletin of experimental biology and medicine

authors： Nesterova YV,Povet'yeva TN,Suslov NI,Zyuz'kov GN,Pushkarskii SV,Aksinenko SG,Schultz EE,Kravtsova SS,Krapivin AV

更新日期：2014-08-01 00:00:00

abstract：:We used tests for evaluation of latent period, duration, and accuracy of eyes, head, or hand movements and their coordinated movements. Comparative analysis of these parameters was performed in healthy subjects and in patients with early stages of Parkinson's disease. The pathology data significantly (p<0.05) differed...

journal_title：Bulletin of experimental biology and medicine

authors： Baziyan BKh

更新日期：2012-12-01 00:00:00

abstract：:hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic ch...

journal_title：Bulletin of experimental biology and medicine

authors： Molodykh OP,Nepomnyashchikh LM,Lushnikova EL,Klinnikova MG

更新日期：2000-09-01 00:00:00

abstract：:The involvement of the studied signal cascades in the regulation of erythropoietin production by bone marrow nuclears under conditions of immobilization stress depends on the type of the hemopoiesis-inducing microenvironment cells and the period of blood system reaction to stress exposure. Secretory activity of monocy...

journal_title：Bulletin of experimental biology and medicine

authors： Miroshnichenko LA,Zhdanov VV,Udut EV,Polyakova TY,Zyuz'kov GN,Simanina EV,Sherstoboev EY,Stavrova LA,Agafonov VI,Minakova MY,Chaikovskii AV,Dygai AM

更新日期：2017-07-01 00:00:00

abstract：:We studied the effect of experimental liver injury of various origins (toxic, autoimmune, alcoholic, and mesenchymal) in the females on motility of spermatozoa in the offspring. The number of infertile (jerking and immotile) spermatozoa increased, whereas the number of fertile spermatozoa (progressive motile and slow ...

journal_title：Bulletin of experimental biology and medicine

authors： Bryukhin GV,Sizonenko ML

更新日期：2014-11-01 00:00:00

abstract：:Changes in the muscular tissue after subcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and additionally stained with cell membrane dye Vybrant CM-Dil in the projection of ligated femoral vein were studied by light microscopy with luminescence. Stromal cell...

journal_title：Bulletin of experimental biology and medicine

authors： Maiborodin IV,Morozov VV,Anikeev AA,Maslov RV,Figurenko NF,Matveeva VA,Maiborodina VI

更新日期：2018-03-01 00:00:00

abstract：:Initiation of apoptosis by chemotherapeutic drugs is one of the most effective approaches to the treatment of cancers. Caspases, the main enzymes of apoptosis, undergo activation to initiate cell death. Activation of initiator caspases requires their binding to special protein complexes. For elucidation of the mechani...

journal_title：Bulletin of experimental biology and medicine

authors： Zamaraev AV,Egorshina AY,Lavrik IN,Zhivotovsky BD,Kopeina GS

更新日期：2019-11-01 00:00:00

abstract：:Kinetics of DNA synthesis in mitotic cycle of in mouse corneal epithelial cells after γ-irradiation in different S phase points was studied by the method of autoradiography. Normally, S phase of corneal epithelial cells consists of two phases (S1 and S2) separated by an interval without DNA synthesis. Each phase, in t...

journal_title：Bulletin of experimental biology and medicine

authors： Shabalkin IP,Grigor'eva EY,Shabalkin PI,Gudkova MV

更新日期：2014-11-01 00:00:00

abstract：:Data are presented on chemical study of flavonoid glycosides in some botanical subjects using matrix-assisted laser desorption ionization, compared to HPLC. The method of matrix-assisted laser desorption ionization (MALDI) allows characterizing the composition of anthocyanin and flavonoid mixture without preliminary s...

journal_title：Bulletin of experimental biology and medicine

authors： Novikov OO,Pisarev DI,Zhilyakova ET,Novikova MY,Pisareva NA,Voronkova OS,Bezmenova MD

更新日期：2013-01-01 00:00:00