Using the matrix-assisted laser desorption ionization for the analysis of flavonoid glycosides in objects of plant origin.

abstract：:Brain-derived neurotrophic factor (BDNF) plays the central role in the mechanisms of regulation of neurogenesis and neuroplasticity. Impairment of these mechanisms is considered as one of the main etiological factors of depression. Dimeric dipeptide mimetic of BDNF loop 4 bis-(N-monosuccinyl-l-seryl-l-lysine) hexameth...

journal_title：Bulletin of experimental biology and medicine

authors： Gudasheva TA,Povarnina PY,Seredenin SB

更新日期：2017-02-01 00:00:00

abstract：:Leukocyte count decreased, relative content of neutrophils and monocytes increased, and their phagocytic activity was suppressed in rats with 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced depressive syndrome at the stage of acute behavioral depression. The severity of behavioral depression inversely correlated ...

journal_title：Bulletin of experimental biology and medicine

authors： Krupina NA,Davydova TV,Fomina VG,Kryzhanovskii GN,Orlova IN

更新日期：2000-11-01 00:00:00

abstract：:The concentrations of the key factors of molecular pathogenesis of prehypertension (angiotensin II, HLDF24, S100b, endothelin, autoantibodies to these molecules, and VEGF) were analyzed in subjects with optimal BP (<120/80 mm Hg) and prehypertension (120-139/80-89 mm Hg). Comparative and correlation analysis of the le...

journal_title：Bulletin of experimental biology and medicine

authors： Sherstnev VV,Gruden MA,Karlina VP,Ryzhov VM,Kuznetsova AV,Senko OV

更新日期：2020-01-01 00:00:00

abstract：:Pial arteries of different diameter were studied in intact rats and after 6-month modeling of chronic tobacco smoking in rats. Expression of tachykinin NK1 receptors in pial arteries was studied by biomicroscopy and immunohistochemical methods. Chronic tobacco smoking induced considerable reorganizations of the arteri...

journal_title：Bulletin of experimental biology and medicine

authors： Zakharchuk NV,Chertok VM,Nevzorova VA,Gonchar EY

更新日期：2017-07-01 00:00:00

abstract：:The study included 52 patients at a high risk of thromboembolic complications, with permanent atrial fibrillation. All patients were treated with acenocoumarol for 6 months and the incidence of hemorrhages was evaluated in all of them. All patients were genotyped by CYP2C9 and VKORC1. The presence of CYP2C9*2 and CYP2...

journal_title：Bulletin of experimental biology and medicine

authors： Sychev DV,Ignatyev IV,Emelyanov NV,Milovanova VV,Kossovskaya AV,Kukes IV,Tashenova AI,Kukes VG

更新日期：2012-10-01 00:00:00

abstract：:Treatment with a combination of artrofoon and anaferon significantly reduced clinical and laboratory parameters of rheumatoid inflammation and significantly decreased the content of antiinflammatory cytokines in the blood. These findings attest to antiinflammatory and immunomodulating effects of these preparations. ...

journal_title：Bulletin of experimental biology and medicine

authors： Petrov VI,Babaeva AR,Solodenkova KS,Cherevkova EV,Zabolotneva YA,Kachanova MV,Sergeeva SA

更新日期：2009-09-01 00:00:00

abstract：:The relationships between open field behavior, initial nociceptive thresholds, and immunoreactivity assessed according to the development of hyperthermia triggered by LPS pyrogenal were examined in Wistar rats. Behaviorally active animals demonstrated higher nociceptive thresholds and greater immunoreactivity in compa...

journal_title：Bulletin of experimental biology and medicine

authors： Abramova AY,Abramov YB

更新日期：2011-12-01 00:00:00

abstract：:The levels of natural antibodies to β-endorphin, bradykinin, histamine, dopamine, and serotonin were measured in 271 cardiological patients in order to evaluate the severity of their clinical status. The patients were distributed into groups differing by the course of the pathological process. The levels of natural an...

journal_title：Bulletin of experimental biology and medicine

authors： Morozova VS,Petrochenko SN,Myagkova MA,Bachurin SO

更新日期：2017-05-01 00:00:00

abstract：:The effect of melanin solutions on the skin exposed to UV irradiation (1,050 kJ/m(2)) depended on its dose and varied from photoprotection (0.005 mg/ml) to photosensitization and phototoxicity (burn, 0.1 mg/ml). These results suggest that doses of melanin preparations should be empirically selected to achieve optimum ...

journal_title：Bulletin of experimental biology and medicine

authors： Paramonov BA,Turkovskii II,Potokin IL,Chebotarev VY

更新日期：2002-04-01 00:00:00

abstract：:Antiaggregant activity of a new tricyclic benzimidazole derivative, RU-891 compound, was studied on the model of ADP-induced platelet aggregation in vitro and intravascular platelet aggregation in vivo. We evaluated the effect of this substance on blood coagulation potential. Antiaggregant agent acetylsalicylic acid w...

journal_title：Bulletin of experimental biology and medicine

authors： Kucheryavenko AF,Spasov AA,Petrov VI,Anisimova VA

更新日期：2014-04-01 00:00:00

abstract：:We studied etiologic structure of bacterial intestinal infections in monkeys of Adler nursery. A total of 533 monkeys with diarrhea syndrome and monkeys dead from intestinal infections, as well as clinically healthy monkeys and animals dead from other pathologies were examined by bacteriological and molecular-genetic ...

journal_title：Bulletin of experimental biology and medicine

authors： Ardasheliya SN,Kalashnikova VA,Dzhikidze EK

更新日期：2011-10-01 00:00:00

abstract：:Initiation of apoptosis by chemotherapeutic drugs is one of the most effective approaches to the treatment of cancers. Caspases, the main enzymes of apoptosis, undergo activation to initiate cell death. Activation of initiator caspases requires their binding to special protein complexes. For elucidation of the mechani...

journal_title：Bulletin of experimental biology and medicine

authors： Zamaraev AV,Egorshina AY,Lavrik IN,Zhivotovsky BD,Kopeina GS

更新日期：2019-11-01 00:00:00

abstract：:Elimination of platelets from guinea pig splenocyte suspension (lacking megakaryocytes) with EDTA considerable reduces the efficiency cloning of splenic stromal precursor cells. It means that platelet-derived growth factors are necessary for stromal precursor cells from different organs (bone marrow, thymus, and splee...

journal_title：Bulletin of experimental biology and medicine

authors： Gorskaya YF,Shuklina EY,Nesterenko VG

更新日期：2002-03-01 00:00:00

abstract：:Studies of the molecular mechanisms of esophageal cancer development have to be carried out on sufficient amount of tumor material, obtained under conditions of controlled exposure to carcinogenic factors. Esophageal cancer models on laboratory animals serve an indispensable source of this material. One of these model...

journal_title：Bulletin of experimental biology and medicine

authors： Shubin AV,Lesovaya EA,Kirsanov KI,Antoshina EE,Trukhanova LS,Gorkova TG,Belitsky GA,Yakubovskaya MG,Demidyuk IV

更新日期：2018-03-01 00:00:00

abstract：:C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fi...

journal_title：Bulletin of experimental biology and medicine

authors： Kovner AV,Anikina AG,Potapova OV,Sharkova TV,Cherdanceva LA,Shkurupy VA,Shestopalov AM

更新日期：2012-06-01 00:00:00

abstract：:We studied properties of bacterial biofilms during long-term culturing. The biofilms were preserved for more than 90 days under the chosen conditions. At the same time, amounts of matrix and cells underwent periodic changes. The biomass of the biofilms decreased approximately every 7 days and then returned to the prev...

journal_title：Bulletin of experimental biology and medicine

authors： Tetz GV,Artemenko NK,Zaslavskaya NV,Tetz VV

更新日期：2013-08-01 00:00:00

abstract：:"Therapeutic Effects of Salidroside on Cognitive Ability in Rats with Experimental Vascular Dementia," by Z. Tian, Yu. Li, G. Wang, J. Wang, and Ye. Zhang, Vol. 169, No. 1, pp. 35-39, May 2020. ...

journal_title：Bulletin of experimental biology and medicine

authors： Tian Z,Li Y,Wang G,Wang J,Zhang Y

更新日期：2020-06-01 00:00:00

abstract：:We analyzed the dynamics of neuropathic pain development and changes in catalase and superoxide dismutase (SOD) activities in the brain, liver, and skeletal muscles of male Wistar rats with 1-month streptozotocin-induced diabetes mellitus. A decrease in mechanical nociceptive threshold was revealed that progressed dur...

journal_title：Bulletin of experimental biology and medicine

authors： Shipilov VN,Chistyakova OV,Trost AM

更新日期：2016-05-01 00:00:00

abstract：:Studies of the effects of Trichoderma harzianum Rifai F-180 culture fluid concentrate containing L-lysine-α-oxidase antitumor enzyme produced by the fungus and the homogenous enzyme, on ultrahazardous bacterium Acidovorax citrulli demonstrated the antibacterial activity of the concentrate. Trichoderma harzianum Rifai ...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova IP,Karimova EV,Shneider YA,Volina EG

更新日期：2018-03-01 00:00:00

abstract：:One-month therapy with trimetazidine sharply decreased the content of free radical oxidation products, lipid peroxides and malonic dialdehyde, in atherogenic low-density lipoproteins in patients with coronary heart disease. Activity of glutathione peroxidase utilizing lipid peroxides in the plasma markedly increased d...

journal_title：Bulletin of experimental biology and medicine

authors： Tikhaze AK,Lankin VZ,Zharova EA,Kolycheva SV

更新日期：2000-10-01 00:00:00

abstract：:Maximum magnetic resonance artifacts from stents are often determined by the presence of ferromagnetic compounds in the delivery system. We propose a mathematic model describing artifacts caused by nitinol stents. A method for evaluation of critical radial rigidity of the stents was developed. ...

journal_title：Bulletin of experimental biology and medicine

authors： Sergienko VI,Martynov AK,Petryaikin AV,Koshurnikov DS,Fadeev AA,Nikolaev DA,Karmazanovskii GG,Osipova NY,Fedorov VD

更新日期：2007-09-01 00:00:00

abstract：:We studied functional activity of neutrophilic granulocytes and monocytes isolated from the peripheral blood of women during the follicular and luteal phases of the menstrual cycle. It was shown that phagocytic activity of neutrophilic granulocytes increases, their intracellular oxygen-dependent bactericidal activity ...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova TG,Savochkina AY,Dolgushin II,Nikushkina KV,Samuseva IV

更新日期：2018-12-01 00:00:00

abstract：:Blood levels of stem cell marker proteins CD34 and osteonectin were studied in male patients with coronary atherosclerosis by direct biomagnetic separation of proteins with magnetic microspheres using the PureProteome Protein A and Protein G Magnetic Beads proteomic technology. High concentration of osteonectin in the...

journal_title：Bulletin of experimental biology and medicine

authors： Ragino YI,Kashtanova EV,Chernjavski AM,Volkov AM,Polonskaya YV,Tsimbal SY,Eremenko NV,Ivanova MV

更新日期：2011-07-01 00:00:00

abstract：:Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explain...

journal_title：Bulletin of experimental biology and medicine

authors： Titov VN,Sazhina NN

更新日期：2014-12-01 00:00:00

abstract：:Micro- and nanomolar concentrations of ganglioside GM1 improved viability of neuronal PC12 cells under conditions of oxidative stress and reduced H2O2-induced ROS accumulation in these cells. These effects were more pronounced at micromolar concentrations. GM1 in concentrations of 100 nM and 10 μM significantly and su...

journal_title：Bulletin of experimental biology and medicine

authors： Zakharova IO,Sokolova TV,Akhmetshina AO,Avrova NF

更新日期：2015-09-01 00:00:00

abstract：:We studied the role of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) in functional differentiation of HC11 mouse mammary gland cells. It was found that both IGF-1 and IGF-2 activate the expression of milk protein β-casein in the presence of prolactin and hydrocortisone. It was found that β-casein expression is...

journal_title：Bulletin of experimental biology and medicine

authors： Shushanov SS

更新日期：2011-12-01 00:00:00

abstract：:We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locom...

journal_title：Bulletin of experimental biology and medicine

authors： Surina NM,Kalinina TS,Volkova AV,Malikova LA,Poletaeva II,Rayevsky KS,Fedotova IB

更新日期：2011-05-01 00:00:00

abstract：:We studied the effect of mesenchymal stromal cells and conditioned media on healing of full-thickness skin wound in rats. Cell transplantation to the wound bed did not accelerate wound closing and had no effect on the severity of inflammation, but increased vasculariza - tion of the granulation tissue in 14 days after...

journal_title：Bulletin of experimental biology and medicine

authors： Payushina OV,Butorina NN,Sheveleva ON,Domaratskaya EI

更新日期：2018-08-01 00:00:00

abstract：:We studied daily dynamics of proliferative activity of embryonic fibroblast-like cells in culture during the logarithmic growth phase. Daily increase in cell count in the culture showed a 4-day rhythm that persisted over 3 weeks of culturing. In cultures from different animals, the phase of this rhythm was synchronous...

journal_title：Bulletin of experimental biology and medicine

authors： Diatroptova MA,Ponomarenko EA,Diatroptov ME

更新日期：2020-09-01 00:00:00

abstract：:The content of hemopoietic precursors in the bone marrow, its morphological composition, production of hemopoietic growth factors by cells of the hemopoietic microenvironment, erythropoietic activity, and plasma content of endogenous erythropoietin were studied in CBA/CaLac mice with hypoplasia of hemopoiesis induced ...

journal_title：Bulletin of experimental biology and medicine

authors： Dygai AM,Zhdanov VV,Simanina EV,Gur'yantseva LA,Udut EV,Khrichkova TY,Kirienkova EV,Epstein OI,Gol'dberg ED

更新日期：2003-06-01 00:00:00