Regeneration Potential of Lymphoid Tissue of Small Intestine in Mice after Exposure to Low-Intensity Radiation.

Abstract:

:Number and size of aggregated lymphoid nodules in the small intestine of mice exposed to radiation using a γ-irradiation unit GOBO-60 with 137Cs source were measured using the methods of visual microscopy and morphometry. Morphological status of the nodules was estimated on days 4, 28, 60, and 90 after the exposure. Significant changes were observed in the lymphoid system of the small intestine after exposure to low-intensity radiation. The size of aggregated lymphoid nodules decreased and the relative number of cells with degenerative changes increased. Regenerative processes were observed as soon as on day 4 of the rehabilitation period. However, the number and sizes of aggregated lymphoid nodules (length, width, and section area), and the ratio of lymphoid nodules with germinal center were still lower than in the control. The number of cells forming lymphoid interstitial plaques was close to the control on days 28-90 of the rehabilitation process.

journal_name

Bull Exp Biol Med

authors

Klochkova SV,Kvaratskheliya AG,Alekseeva NT,Nikityuk DB

doi

10.1007/s10517-017-3961-1

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

214-217

issue

2

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-017-3961-1

journal_volume

164

pub_type

杂志文章
  • Possible Recovery of Manifestation of Prolactin Receptor and Some of Its Target Proteins in the Liver and Kidney Cells of Female Rats after Relief of Cholestasis Complicated and Not Complicated by Hyperprolactinemia.

    abstract::Immunohistochemistry with semi-quantitative analysis of computer images showed that prolactin receptor and cystic fi brosis transmembrane regulator (CFTR) in cholangiocytes of female rats elevated in cholestasis quickly respond to its relief. The effect of hyperprolactinemia on the extent of return of these proteins t...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2963-0

    authors: Aleksandrova MI,Sirotina NS,Smirnova OV

    更新日期:2015-07-01 00:00:00

  • Epidermocyte nuclear-nucleolar system in atopic dermatitis and lichen planus.

    abstract::Study of the epidermocyte nuclear-nucleolar system in atopic dermatitis and lichen planus by computer morphometry of preparations stained with 50% AgNO3 showed an increase in their morphometric parameters, reflecting hyperregeneratory processes. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0336-z

    authors: Sapuntsova SG,Tsygankov VI,Simkatcheva MV,Timoshin SS

    更新日期:2007-09-01 00:00:00

  • Tartrate-resistant acid phosphatase as a marker of bone metastases in patients with breast cancer and prostate cancer.

    abstract::Serum activity of tartrate-resistant acid phosphatase 5b (TRAP 5b) in patients with breast cancer and prostate cancer having bone metastases was much higher than in healthy donors and patients without skeletal injuries. TRAP 5b activity in patients with breast cancer and multiple bone metastases surpassed that in pati...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000046945.95479.d6

    authors: Lyubimova NV,Pashkov MV,Tyulyandin SA,Gol'dberg VE,Kushlinskii NE

    更新日期:2004-07-01 00:00:00

  • Evaluation of the Effect of p-Tyrosol on the Level of DNA Damage in the DNA Comet Assay In Vivo.

    abstract::The effect of p-tyrosol on the spontaneous level of DNA damage in the cells of the bone marrow, liver, kidney, and rectum of mice (series I) and on the genotoxic effects of cytostatic drugs with different mechanisms of action in rat testicular cells (series II) was studied by DNA comet assay on C57BL/6 mice. p-Tyrosol...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04857-y

    authors: Borovskaya TG,Vychuzhanina AV,Grigor'eva VA,Kollantay OV,Goldberg VE,Dygai AM

    更新日期:2020-06-01 00:00:00

  • Molecular mechanisms of hormone resistance of breast cancer.

    abstract::More than 70% malignant mammary tumors contain steroid hormone receptors; this suggests the possibility of hormone therapy in the majority of patients with breast cancer (BC). The main cause of inefficiency of hormone therapy in BC is hormone resistance (tumor resistance to hormonal cytostatics). Here we discuss the m...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2160-y

    authors: Scherbakov AM,Krasil'nikov MA,Kushlinskii NE

    更新日期:2013-07-01 00:00:00

  • Mechanisms of Erythropoietin-Stimulating Action of Anti-Erythropoietin Release-Active Antibodies in Complex Treatment of Experimental Anemia during Gestation.

    abstract::We studied the mechanisms of erythropoiesis stimulation and effectiveness of Poetam, a preparation containing release-active anti-erythropoietin antibodies as a supplement treatment for experimental iron deficiency anemia during gestation. The results confirmed potency of combined therapy to stimulate erythropoiesis, ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3298-1

    authors: Burmina YV,Udut EV,Zhdanov VV,Sotnikova LS,Miroshnichenko LA,Simanina EV,Polyakova TY,Zyuz'kov GN,Chaikovskii AV,Stavrova LA,Epshtein OI,Dygai AM

    更新日期:2016-04-01 00:00:00

  • A universal method for measuring functional activity of complement in humans, laboratory, domestic, and agricultural animals, amphibians, and birds.

    abstract::A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, me...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2546-5

    authors: Kuleshina ON,Kozlov LV,Cheremnykh EG

    更新日期:2014-06-01 00:00:00

  • Mechanisms of protective effect of Dicarbamin on the blood system in cytostatic treatment.

    abstract::The effect of Dicarbamin preparation on hemopoiesis suppressed with cyclophosphamide was studied in animal experiments. It was shown that Dicarbamin produced a protective effect on granulocytic hemopoietic steam. This property of the preparation is determined by both protection of immature granulocytic cells at early ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1138-x

    authors: Nebolsin VE,Zhdanov VV,Zyuzkov GN,Udut EV,Khrichkova TY,Simanina EV,Stavrova LA,Miroshnichenko LA,Chaikovskiy AV,Dygai AM

    更新日期:2011-01-01 00:00:00

  • Mechanisms of changes in the erythroid hemopoietic stem during hypoxias of different severity.

    abstract::Brain pathology (acute hypoxia and posthypoxic encephalopathy) is associated with less pronounced hyperplasia of the bone marrow erythroid stem (due to decreased count of proliferating committed precursors) and hemolytic anemia, while secretory activity of stromal cells of the hemopoiesis-inducing microenvironment is ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1021167710993

    authors: Gol'dberg ED,Dygai AM,Zyuz'kov GN,Gur'yantseva LA,Suslov NI

    更新日期:2002-08-01 00:00:00

  • Effect of nitroglycerine on content of second messengers in myocytes of rat thoracic aorta.

    abstract::We evaluated the concentration dependence and time dependence of the effect of nitroglycerine on intracellular content of cAMP, cGMP, and free Ca2+. It was shown that after norepinephrine stimulation, nitroglycerine exhibited calcium-blocking activity in lower concentrations (starting from 10(-7) M). Under conditions ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0228-7

    authors: Dukhanin AS,Shimanovskii NL

    更新日期:2006-05-01 00:00:00

  • Effect of tissue phospholipid composition on synergistic interactions between sympathetic and parasympathetic systems.

    abstract::The content of phospholipids in various tissues was studied during synergistic interaction between two branches of the autonomic nervous system. We found higher myocardial content of choline-containing phospholipids and lower rigidity of erythrocyte membranes in rabbits with pronounced sympathetic potentiation of the ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1016203713719

    authors: Lychkova AE,Smirnov VM

    更新日期:2002-04-01 00:00:00

  • Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson's disease.

    abstract::The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopami...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/BF02766101

    authors: Chekhonin VP,Baklaushev VP,Kogan BM,Savchenko EA,Lebedev SV,Man'kovskaya IV,Filatova TS,Yusupova IU,Dmitrieva TB

    更新日期:2000-08-01 00:00:00

  • Neuroprotective Effects of Peptides during Ischemic Preconditioning.

    abstract::Experiments on rats showed that neurospecific protein preparations reduce the severity of neurological deficit, restore the structure of individual behavior of the animals with different hypoxia tolerance, and exert antioxidant action during chronic ischemic damage to the brain unfolding during the early and late phas...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3193-9

    authors: Zarubina IV,Shabanov PD

    更新日期:2016-02-01 00:00:00

  • Effect of Conditioned Medium and Bone Marrow Stem Cell Lysate on the Course of Acetaminophen-Induced Liver Failure.

    abstract::A composition containing culture medium conditioned by mesenchymal stem cells and mesenchymal stem cell lysate improves biochemical parameters, reduces inflammation, and stimulates regenerative processes in the liver. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2905-x

    authors: Khubutiya MSh,Temnov AA,Vagabov VA,Sklifas AN,Rogov KA,Zhgutov YA

    更新日期:2015-05-01 00:00:00

  • The incidence of breast tumor during experimental hyperthyroidism.

    abstract::The incidence of breast tumor in inbred C3H-A mice (virgin female) from hyperthyroid, hypothyroid, and euthyroid control groups at week 44 of the experiment was 86.67, 30, and 62.5%, respectively. The percentage of metastatic lymph nodes in these groups was 65.9±16.7, 35.9±5.9, and 53.9±7.2%, respectively (p<0.005). I...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2322-y

    authors: Glushakov RI,Proshin SN,Tapil'skaya NI

    更新日期:2013-12-01 00:00:00

  • Effects of Intraperitoneal Administration of Mifepristone on Glucocorticoid Status of Experimental Animals.

    abstract::We studied the content of corticosterone and its precursors in the adrenal glands, corticosterone in blood serum and daily urine of rats, and activity of first and second isoforms of 11β-hydroxysteroid dehydrogenase in the liver and kidneys of rats after 15 daily intraperitoneal injections of 0.9% NaCl or glucocortico...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3390-6

    authors: Pal'chikova NA,Kuznetsova NV,Selyatitskaya VG,Cherkasova OP,Kuz'mina OI

    更新日期:2016-06-01 00:00:00

  • Immunotropic effects of hexavalent chromium soluble compounds on the thymus and peripheral blood values in a subacute experiment.

    abstract::Intraperitoneal injections of hexavalent chromium (sodium bichromate) in the concentrations of 0.025 μg/kg (10-fold lower than MAC; group 1) and 2.5 μg/kg (10-fold higher than MAC; group 2) to rats in a subacute experiment caused dose-dependent morphological changes in the thymus: increased the counts of cells in a st...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2387-2

    authors: Zhumabaeva AN,Zarishnyak NV,Bekmukhambetov EZh

    更新日期:2014-02-01 00:00:00

  • Expression of Galectins-1 and Galectin-3 in Stomach and Colorectal Cancer with Tissue Eosinophilia.

    abstract::We analyzed the expression of galectin-1 and galectin-3 in tumor tissue in stomach and colorectal cancer with and without tissue eosinophilia. Low expression of galectin-3 was detected in all patients with malignant gastrointestinal tumors irrespective of the presence of eosinophilia. Low expression of galectin-1 was ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4142-6

    authors: Kolobovnikova YV,Dmitrieva AI,Yankovich KI,Vasil'eva OA,Purlik IL,Poletika VS,Novitskii VV,Urazova OI

    更新日期:2018-06-01 00:00:00

  • Effect of carnosine and related compounds on proliferation of cultured rat pheochromocytoma PC-12 cells.

    abstract::The study was undertaken to determine the mechanism of carnosine effect on cell proliferation. We studied the effect of carnosine and its derivatives on cell cycle progression in cultured rat pheochromocytoma cells (PC-12). It was found that 48-h incubation of PC-12 cells with carnosine in concentrations of 10-50 mM l...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1894-2

    authors: Rybakova YS,Boldyrev AA

    更新日期:2012-11-01 00:00:00

  • Effects of Thermoextracts of Brucella S and L Forms on Lipid Peroxidation and Antioxidant Defense in Organs of Laboratory Animals.

    abstract::The dynamics of LPO marker malondialdehyde formation and peroxidase-destroying activity was studied in homogenized organs of guinea pigs, immunized with thermoextracts from S and L forms Brucella abortus I-206. The L form brucella thermoextract exhibited a lower reactogenicity and adequately activated the antioxidant ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4138-2

    authors: Dubrovina VI,Balakhonov SV,Yurieva OV,Starovoitova TP,Barannikova NL,Tokareva LE,Pyatidesyatnikova AB,Yastremskaya KY,Shkaruba TT

    更新日期:2018-06-01 00:00:00

  • Preclinical Study of Pharmacological Properties of Doxorubicin-NPh.

    abstract::Preclinical study of therapeutic properties of an innovative drug Doxorubicin-NPh (doxorubicin in the form of ultrafine suspension of phospholipid liposomes) in comparison with free doxorubicin (Doxorubicin-Teva) and protected doxorubicin (Caelyx) was performed on transplanted murine tumor models. All these drugs were...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04977-5

    authors: Nemtsova ER,Tikhonova EG,Bezborodova OA,Pankratov AA,Venediktova JB,Korotkevich EI,Kostryukova LV,Tereshkina JA

    更新日期:2020-10-01 00:00:00

  • Mathematical simulation of p53-Mdm2 protein biological system regulation.

    abstract::Digital simulation of disorders in the p53 and Mdm2 protein system, involved in repair of DNA defects and in many vital processes, including tumor formation, neurodegeneration, and aging, was carried out on the base of functional nonlinear octoparametric mathematical model. Stress situations were studied, associated w...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2608-8

    authors: Voropaeva OF,Shokin YI,Nepomnyashchikh LM,Senchukova SR

    更新日期:2014-08-01 00:00:00

  • Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis.

    abstract::Morphological changes in the mesenteric lymph nodes of male C57Bl/6 mice and subpopulation composition of lymphocytes in these nodes were studied in experimental acute and chronic ulcerative colitis induced by sodium dextran sulfate. Acute and chronic ulcerative colitis was associated with the development of reactive ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3322-5

    authors: Postovalova EA,Khochansky DN,Zolotova NA,Gao Y,Makarova OV,Dobrynina MT

    更新日期:2016-04-01 00:00:00

  • Anti-inflammatory effects of simvastatin in patients with chronic heart failure.

    abstract::Proinflammatory markers were evaluated in patients with chronic heart failure of ischemic origin and essential hypertension with preserved left-ventricular ejection fraction before and after a 6-month course of simvastatin therapy (20 mg/day). The study was carried out in 125 patients with diastolic dysfunction manife...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2612-z

    authors: Pinchuk TV,Fedulaev YN,Khairetdinova GA,Denisova NN,Chura OV,Logunova IY

    更新日期:2014-09-01 00:00:00

  • Circulating Proteasomes in the Pathogenesis of Head and Neck Squamous Cell Carcinoma.

    abstract::Increased proteasome activity was revealed in blood serum of patients with stage T1N0M0 head and neck squamous cell carcinoma in comparison with patients with chronic diseases of the larynx and laryngopharynx. This opens prospects of using chymotrypsin-like activity measurement for differential diagnosis of squamous c...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3745-7

    authors: Kakurina GV,Cheremisina OV,Choinzonov EL,Kondakova IV

    更新日期:2017-05-01 00:00:00

  • Changes in phenotype of monocyte-like THP-1 cells associated with transendothelial migration.

    abstract::The level of expression of CD11b and HLA-DR surface molecules on monocyte-like THP-1 cells increased significantly as a result of transmigration of these cells through a monolayer of endothelial cells. The expression of all studied markers (CD11b, HLA-DR, and CD-14) increased significantly after transendothelial migra...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0350-4

    authors: Starikova EA,Sokolov DI,Chernova AA,Freidlin IS

    更新日期:2008-11-01 00:00:00

  • Antimutagenic activity of afobazole in various regimens of treatment.

    abstract::The influence of a new 2-mercaptobenzimidazole derivative afobazole on cytogenetic effects of dioxidine and cyclophosphamide was studied by counting chromosome aberrations in bone marrow cells of C57Bl/6 mice. Afobazole (1-100 mg/kg perorally) exhibited antimutagenic activity determined by its antioxidant properties. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:

    authors: Zhanataev AK,Durnev AD,Seredin SB

    更新日期:2000-11-01 00:00:00

  • Inhibition of thrombin activity with DNA-aptamers.

    abstract::The effects of two DNA aptamers (oligonucleotides) 15TBA and 31TBA (15- and 31-mer thrombin-binding aptamers, respectively) on thrombin activity were studied. Both aptamers added to human plasma dose-dependently increased thrombin time (fibrin formation upon exposure to exogenous thrombin), prothrombin time (clotting ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0627-7

    authors: Dobrovolsky AB,Titaeva EV,Khaspekova SG,Spiridonova VA,Kopylov AM,Mazurov AV

    更新日期:2009-07-01 00:00:00

  • Endogenous progenitors as the source of cell material for ischemic damage repair in experimental myocardial infarction under conditions of changed concentration of vascular endothelial growth factor.

    abstract::We studied the effect of VEGF-A in experimental myocardial infarction on attraction of progenitor cells into the regeneration zone. The appearance of CD34(+)CD45(+) cells known as low-differentiated progenitor cells was observed in the damaged myocardial tissue in the presence of a considerable excess of VEGF-A. These...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2801-4

    authors: Shurygin MG,Shurygina IA,Dremina NN,Kanya OV

    更新日期:2015-02-01 00:00:00

  • Proteoglycans and human breast cancer.

    abstract::Comparative analysis of proteoglycans in the control and tumor tissue of human mammary gland revealed disorders in the biosynthesis of dermatan sulfate proteoglycans in tumor cells. Using the methods of reverse transcription-PCR and Western blotting for the analysis of decorin expression we showed that these disorders...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0326-1

    authors: Rykova VI,Grigorieva EV,Chernenko AV,Eshenko TY,Dymshits GM

    更新日期:2007-09-01 00:00:00