Abstract：
:Proinflammatory markers were evaluated in patients with chronic heart failure of ischemic origin and essential hypertension with preserved left-ventricular ejection fraction before and after a 6-month course of simvastatin therapy (20 mg/day). The study was carried out in 125 patients with diastolic dysfunction manifested as impaired relaxation and pseudonormalization. The main group received standard therapy for chronic heart failure and simvastatin, controls received only standard therapy. In addition, the results in the main group were compared in patients with different types of left-ventricular diastolic dysfunction. Simvastatin therapy significantly reduced the levels of C-reactive protein and IL-6.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Pinchuk TV,Fedulaev YN,Khairetdinova GA,Denisova NN,Chura OV,Logunova IYdoi
10.1007/s10517-014-2612-zsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
552-4issue
5eissn
0007-4888issn
1573-8221journal_volume
157pub_type
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