Abstract:
:We designed a new complex drug with antiallergic effect containing, in addition to the main component loratadine, a phytocomplex for an extra therapeutic effect. A collection of plants with sedative activity is chosen and the optimal agent for extraction of bioactive compounds (40% ethanol) and optimal degree of plant fragmentation are determined. Chemical composition of the sedative tea is evaluated by reverse phase HPLC. The marker components of the species are detected: xanthohumol and isoxanthohumol - Humulus lupulus cone components, Mentha piperita rosmarinic acid, and scutellareine, Menyanthes trifolia element - quercetin-3-rutinoside, and caffeic acid. Standardization of the species by the absolute graduation method in conversion to quercetin-3-rutinoside is suggested.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kulikovskii VF,Zhilyakova ET,Novikov OO,Pisarev DI,Prokushchenko NV,Ivanova LLdoi
10.1007/s10517-017-3896-6subject
Has Abstractpub_date
2017-10-01 00:00:00pages
753-756issue
6eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3896-6journal_volume
163pub_type
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