Abstract：
:Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of this phenomenon was explained by the direct effects of alkaloids on precursors and by higher production of growth factors by the skin stromal cells. Songorine exhibited the most pronounced specific activity due to more significant stimulation of progenitor cell differentiation associated with maximum activation of the secretory function of the microenvironment cells.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Zyuz'kov GN,Krapivin AV,Nesterova YV,Povetieva TN,Zhdanov VV,Suslov NI,Fomina TI,Udut EV,Miroshnichenko LA,Simanina EV,Semenov AA,Kravtsova SS,Dygai AMsubject
Has Abstractpub_date
2012-10-01 00:00:00pages
846-50issue
6eissn
0007-4888issn
1573-8221journal_volume
153pub_type
杂志文章abstract：:The local anaphylactic reaction and the effects of histamine during blocking of the slow sodium-calcium channels by isoptine were investigated in the spontaneously contracting oracle of the atrium of a guinea pig previously sensitized to egg albumin. Simultaneously with the intracellular recording of the potentials, i...
journal_title：Bulletin of experimental biology and medicine
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