Proliferation, Migration, and Production of Nitric Oxide by Bone Marrow Multipotent Mesenchymal Stromal Cells from Wistar Rats in Hypoxia and Hyperglycemia.

abstract：:The peculiarities of the histological structure and morphometrical parameters of the dentition in ISIAH rats (inherited stress-induced arterial hypertension) before stress and after modeling of everyday life stress regimen (chronic stress) were compared with those in WAG rats. The area of blood vessels of the periodon...

journal_title：Bulletin of experimental biology and medicine

authors： Kolesnikova LR,Darenskaya MA,Kolesnikova LI,Grebenkina LA,Korytov LI,Batoroev YK,Belinskaya EI,Mikhalevich IM,Kolesnikov SI

更新日期：2019-05-01 00:00:00

abstract：:The efficiency of ascorbate and alpha-tocopherol as stabilizers of beta-carotene, which is widely used in complex therapy and prevention of some diseases accompanied by oxidative stress, was studied. The latency of induced beta-carotene oxidation linearly depends on ascorbate concentration, while steady-state rate non...

journal_title：Bulletin of experimental biology and medicine

authors： Kozachenko AI,Gurevich SM,Nagler LG

更新日期：2000-07-01 00:00:00

abstract：:Groups of microRNA genes, methylation of which is associated with the initial (I-II) stages of breast cancer, are determined, and new markers and marker systems for the disease diagnosis were created on the basis of these data. A total of 14 genes in which methylation was associated with breast cancer were identified ...

journal_title：Bulletin of experimental biology and medicine

authors： Braga EA,Filippova EA,Loginov VI,Pronina IV,Burdennyi AM,Kazubskaya TP,Fridman MV,Khodyrev DS,Kushlinskii NE

更新日期：2019-12-01 00:00:00

abstract：:The development and manufacturing of serum-free culture media allowing reducing the costs of preparations and standardizing the biotechnological process are important trends in biotechnology. Substitution of protein compounds in the serum-free media with recombinant analogues reduces the risk of contamination with var...

journal_title：Bulletin of experimental biology and medicine

authors： Bobik TV,Popov RY,Aliev TK,Mokrushina YA,Shamborant OG,Khurs EN,Knorre VD,Smirnov IV,Gabibov AG

更新日期：2019-07-01 00:00:00

abstract：:Formation of Ala-Glu-Asp-Gly peptide complex with duplex DNA [poly(dA-dT):poly(dA-dT)] at neutral pH and ambient temperature was studied experimentally. Peptide binding to duplex DNA was associated with hyperchromic effect indicating local separation of the double helix. Energies of paired interactions between amino a...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Solovyov AY,Shataeva LK

更新日期：2006-04-01 00:00:00

abstract：:The efficiency of drug therapy should be evaluated by not only its directed action on specific organ or target parameter, but also its effects on general regulatory and adaptive status. ...

journal_title：Bulletin of experimental biology and medicine

authors： Pokrovskii VM,Kompaniets OG

更新日期：2008-06-01 00:00:00

abstract：:Castration had no effect on baseline BP and vascular sensitivity to acetylcholine and deficiency of nitric oxide and prostacyclin in normotensive specimens. Castration of hypertensive specimens decreased BP and potentiated the hypotensive effects of acetylcholine, but did not modulate vascular sensitivity to the block...

journal_title：Bulletin of experimental biology and medicine

authors： Semyachkina-Glushkovskaya OV,Anishchenko TG,Kuznetsova AS,Kuznetsova YV,Bibikova OA,Sjestnova AA

更新日期：2012-06-01 00:00:00

abstract：:We studied properties of cloned BACE mRNA (beta-site of the enzyme cleaving amyloid precursor protein) and evaluated the possibility of using this clone for identification and/or prediction of neurodegenerative disorders associated with cholinergic deficiency. Wistar rats subjected to immunohistochemical destruction o...

journal_title：Bulletin of experimental biology and medicine

authors： Lushchekina EA,Bigl M,Apelt J,Lange-Dohna C,Rossner S,Schliebs R

更新日期：2002-09-01 00:00:00

abstract：:The concentration of tissue inhibitor of type 1 metalloproteinases in blood serum from intact CBA mice measured by enzyme immunoassay is similar to that in healthy humans. The concentration of tissue inhibitor of type 1 metalloproteinases in mouse bile was higher than in blood serum, while its concentration in liver h...

journal_title：Bulletin of experimental biology and medicine

authors： Korolenko TA,Filatova TG,Savchenko NG,Yuz'ko YV,Goncharova IA,Alexeenko TV

更新日期：2007-03-01 00:00:00

abstract：:Mice lacking dynein arms in the cilia were examined; the strain was obtained by inactivation of dynein heavy chain gene in chromosome 7. The cilia of these mice were examined by electron microscopy and compared to the cilia of random-bred mice. No statistically significant differences or typical disorders in the outer...

journal_title：Bulletin of experimental biology and medicine

authors： Ebsen M,Morgenroth K,Neesen J

更新日期：2004-06-01 00:00:00

abstract：:Effects of local therapy with miacalcic on the metabolism in articular connective tissue structures under conditions of experimental arthritis are shown. An effect modifying articular tissue metabolism and an antiinflammatory effect preventing the development of inflammatory destructive processes in rabbit articular t...

journal_title：Bulletin of experimental biology and medicine

authors： Belova SV

更新日期：2007-03-01 00:00:00

abstract：:Burn trauma increased blood chemiluminescence, while lipopolysaccharide in a dose of 1 mg/kg potentiated this effect, activated LPO, and decreased plasma antioxidant activity. In erythrocytes, superoxide dismutase activity increased, while activity of peroxide-utilizing enzymes decreased. Myeloperoxidase content incre...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhal'chik EV,Titkova SM,Anurov MV,Ettinger AP,Korkina LG

更新日期：2006-06-01 00:00:00

abstract：:Oxidized dextran is suggested for prevention of infection induced by influenza A/H5N1 viruses, methods of its use and doses are determined. Two intravenous injections of dextran 3 and 1 days before experimental infection of outbred mice by influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus resulted in a high preven...

journal_title：Bulletin of experimental biology and medicine

authors： Shkurupy VA,Potapova OV,Sharkova TV,Troitskii AV,Gulyaeva EP,Bystrova TN,Shestopalov AM

更新日期：2014-11-01 00:00:00

abstract：:The effect of laser radiation on generation of reactive oxygen species in the whole blood from patients with chronic obstructive pulmonary disease was studied by in vitro recording of luminol-dependent chemiluminescence. Laser irradiation of the blood from patients with increased production of reactive oxygen species ...

journal_title：Bulletin of experimental biology and medicine

authors： Farkhutdinov UR,Farkhutdinov ShU

更新日期：2007-08-01 00:00:00

abstract：:Initiation of apoptosis by chemotherapeutic drugs is one of the most effective approaches to the treatment of cancers. Caspases, the main enzymes of apoptosis, undergo activation to initiate cell death. Activation of initiator caspases requires their binding to special protein complexes. For elucidation of the mechani...

journal_title：Bulletin of experimental biology and medicine

authors： Zamaraev AV,Egorshina AY,Lavrik IN,Zhivotovsky BD,Kopeina GS

更新日期：2019-11-01 00:00:00

abstract：:cDNA encoding VEGF and Ig-like extracellular domains 2-4 of VEGFR-1 (sFlt-1(2-4)) were cloned into prokaryotic expression vectors pET32a and pQE60. Recombinant proteins were purified (metal affinity chromatography) and renatured. Chemiluminescent study for the interaction of recombinant VEGF and sFlt-1(2-4) showed tha...

journal_title：Bulletin of experimental biology and medicine

authors： Leopol'd AV,Baklaushev VP,Korchagina AA,Shein SA,Grinenko NF,Pavlov KA,Ryabukhin IA,Chekhonin VP

更新日期：2012-04-01 00:00:00

abstract：:We studied the effect of bone marrow Thy 1,2+ cells on the growth of erythroid colonies and the role of monoamine in the regulation of proliferation and differentiation of erythroid precursor cells in experimental neuroses. Under conditions of conflict situation Thy 1,2+ cells stimulated the growth of erythropoietic p...

journal_title：Bulletin of experimental biology and medicine

authors： Skurikhin EG,Provalova NV,Pershina OV,Minakova MY

更新日期：2005-11-01 00:00:00

abstract：:Changes in the amplitude and dynamic parameters of purposive saccades were studied in monkeys with MPTP-induced Parkinson-like syndrome. Lengthening of saccade latency, decreased maximum velocity of eye movements, and impaired saccade accuracy were observed at the early stages MPTP-syndrome. Different disturbances of ...

journal_title：Bulletin of experimental biology and medicine

authors： Tereshchenko LV,Yudin AG,Kuznetsov Y,Latanov AV,Shul'govskii VV

更新日期：2002-02-01 00:00:00

abstract：:Using rat model of spinal cord contusion injury at TVIII, we compared the effectiveness of immediate single transplantation of human mononuclear umbilical cord blood cells transfected with pBud-VEGF-FGF2 plasmid and immediate direct injection of the same plasmid into the lesion area. The results suggest that the deliv...

journal_title：Bulletin of experimental biology and medicine

authors： Shaymardanova GF,Mukhamedshina YO,Salafutdinov II,Rizvanov AA,Chelyshev YA

更新日期：2013-02-01 00:00:00

abstract：:Threefold administration of benz(a)pyrene in a dose of 20 mg/kg markedly stimulated biliary excretion of lysosomal enzymes from rat liver without signs of lysosomal damage. Constant light exposure induced changes attesting to functional activation of the lysosomal apparatus in liver cells and inhibited constitutive bi...

journal_title：Bulletin of experimental biology and medicine

authors： Pupyshev AB,Gutina EM,Fedina RG,Michurina SV,Shurlygina AV,Verbitskaya LV

更新日期：2005-01-01 00:00:00

abstract：:We studied the neuroprotective effect of a new selective anxiolytic afobazole on rats with bilateral focal ischemic stroke in the prefrontal cortex caused by photothrombosis. Intraperitoneal injection of 5 mg/kg afobazole 1 h after surgery and over the next 8 days (daily treatment) produced a neuroprotective effect. A...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Romanova GA,Shakova FM

更新日期：2008-02-01 00:00:00

abstract：:Moderate hypothermia stimulates LPO processes in rat plasma and erythrocytes and simultaneously increases antioxidant activity in the plasma and SOD activity erythrocyte. Dalargin prevents stimulation of LPO in the blood in hypothermia by reducing the generation of active oxygen species and maintaining the level of lo...

journal_title：Bulletin of experimental biology and medicine

authors： Tadzhibova LT,Astaeva MD,Ismailova JG,Daudova TN,Klichkhanov NK

更新日期：2011-01-01 00:00:00

abstract：:Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank dem...

journal_title：Bulletin of experimental biology and medicine

authors： Rogozinskaya EY,Lyapina MG

更新日期：2017-12-01 00:00:00

abstract：:Using an integral qualitative and quantitative approach to the studies of initiation of the biological material crystallogenesis, we showed in experiments with normal human saliva that the external characteristics of biological fluid (pH, osmolality, and environmental temperature) determine the results of crystallizat...

journal_title：Bulletin of experimental biology and medicine

authors： Martusevich AK,Kamakin NF

更新日期：2007-03-01 00:00:00

abstract：:Cardiac and plasma activities of marker lysosomal enzymes were studied in Wistar rats with metabolic (epinephrine) and occlusion (ligation of coronary arteries) myocardial infarction. Activity of all examined lysosomal enzymes significantly increased in the myocardium and blood plasma starting from the first day after...

journal_title：Bulletin of experimental biology and medicine

authors： Mayanskaya SD,Mayanskaya NN,Efremov AV,Yakobson GS

更新日期：2000-06-01 00:00:00

abstract：:Electron microscopic study of changes in cultured cells caused by Vibrio cholerae recombinant hemagglutinin/protease (HA/P) showed significant structural changes, most pronounced in HeLa and L-929 cells not forming a compact monolayer with tight junctions between the cells: formation of numerous vesicles on the cell s...

journal_title：Bulletin of experimental biology and medicine

authors： Sayamov SR,Monakhova EV,Fedorenko GM,Tkacheva TI,Markina OV,Alekseeva LP,Pisanov RV,Bardakhchian EA

更新日期：2012-02-01 00:00:00

abstract：:Newborn rats received intraperitoneal injections of endothelin-1 in a daily dose of 5 x 10(-8)mol/kg 30 min after administration of NG-nitro-L-arginine methyl ester (9.3 x 10(-5)mol/kg intraperitoneally) from the 2nd to 6th day of life. NADPH diaphorase activity in epithelial and smooth muscle cells of the tracheobron...

journal_title：Bulletin of experimental biology and medicine

authors： Lebed'ko OA,Timoshin SS,Tsygankov VI

更新日期：2002-03-01 00:00:00

abstract：:We studied the effect of sodium hydrosulfite (NaHS), a donor of hydrogen sulfide (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the prep...

journal_title：Bulletin of experimental biology and medicine

authors： Shafigullin MY,Zefirov RA,Sabirullina GI,Zefirov AL,Sitdikova GF

更新日期：2014-07-01 00:00:00

abstract：:The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system. Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxidant-antioxidant imbalance was least pronounced during selectiv...

journal_title：Bulletin of experimental biology and medicine

authors： Glebov AN,Zinchuk VV

更新日期：2006-04-01 00:00:00

abstract：:The dynamics of coenzyme Q10 concentration in the blood plasma, liver, and brain of passive and active rats was studied on the model of metabolic stress. This parameter was shown to differ in rats with various patterns of behavior. Dietary consumption of coenzyme Q10 in doses of 10 and 100 mg/kg body weight was follow...

journal_title：Bulletin of experimental biology and medicine

authors： Kirbaeva NV,Sharanova NE,Baturina VA,Zhminchenko VM,Pertsov SS,Vasil'ev AV

更新日期：2016-09-01 00:00:00