Neuroprotective effect of afobazole on rats with bilateral local photothrombosis of vessels in the prefrontal cortex.

Abstract:

:We studied the neuroprotective effect of a new selective anxiolytic afobazole on rats with bilateral focal ischemic stroke in the prefrontal cortex caused by photothrombosis. Intraperitoneal injection of 5 mg/kg afobazole 1 h after surgery and over the next 8 days (daily treatment) produced a neuroprotective effect. Afobazole was far superior to the reference cerebroprotective drug cavinton (4 mg/kg) by neuroprotective activity.

journal_name

Bull Exp Biol Med

authors

Seredenin SB,Romanova GA,Shakova FM

doi

10.1007/s10517-008-0051-4

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

207-9

issue

2

eissn

0007-4888

issn

1573-8221

journal_volume

145

pub_type

杂志文章
  • Functional heterogeneity of the "transporter" of electrogenic ionic pump of the Lumbricus terrestris somatic myocyte membrane.

    abstract::Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K(+) after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive "stationary" component, and a lower "regulatory" component sensitive to ouabaine, furosemi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0461-0

    authors: Volkov EM,Sabirova AR,Nurullin LF,Zefirov AL

    更新日期:2006-12-01 00:00:00

  • Role of cyclic nucleotides and NO synthase in mechanisms of cardioprotective effects of cannabinoid HU-210.

    abstract::Isolated perfused rat heart was subjected to global ischemia (45 min) followed by reperfusion (30 min). Under these conditions, the level of creatine phosphokinase in the perfusate increased by 4.5 times. Perfusion (10 min) of the isolated heart with a solution containing cannabinoid HU-210 (0.1 or 1.0 μmol/liter) was...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2622-x

    authors: Maslov LN,Krylatov AV,Lishmanov YB

    更新日期:2014-09-01 00:00:00

  • Reductase activity of 17beta-hydroxysteroid oxidoreductase in prostatic tumors of different histological structure.

    abstract::Reductase activity of 17beta-hydroxysteroid oxidoreductase in biopsy specimens of prostatic cancer and benign hyperplasia, and prostatic intraepithelial neoplasia and serum concentrations of testosterone, 5alpha-dihydrotestosterone, 4-androstene-3,17-dione were compared in patients and healthy individuals. Reductase a...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0387-y

    authors: Degtyar VG,Babkina TV,Kazantseva IA,Morozov AP,Trapeznikova MF,Kushlinskii NE

    更新日期:2005-06-01 00:00:00

  • Effect of Linagliptin on the Ratio of Apoptosis Regulators in the Model of Non-Alcoholic Fatty Liver Disease in db/db Mice.

    abstract::We studied the effects of dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin on the expression of apoptosis regulator proteins Bcl-2 and Bad in the liver of db/db mice with genetically determined obesity and type 2 diabetes mellitus. The mice received daily linagliptin or saline (placebo) by gavage from week 10 to we...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04493-1

    authors: Michurina SV,Cherepanova MA,Ishchenko IY,Arkhipov SA,Klimontov VV,Zav'yalov EL

    更新日期:2019-06-01 00:00:00

  • Parameters of cellular immunity in perimenopausal patients with glandular and adenomatous endometrial hyperplasia.

    abstract::No appreciable disorders of cellular immunity were detected in patients with glandular cystic endometrial hyperplasia. Atypical endometrial hyperplasia was associated with quantitative changes in T lymphocytes and their subpopulations, decreased level of lymphocytes carrying activation antigens, and increased count of...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1023410332246

    authors: Lysenko ON,Strizhova NV,Kholodova ZhL

    更新日期:2003-01-01 00:00:00

  • Mechanisms of cervico-vestibular-oculomotor disorders at the early stages of Parkinson's disease.

    abstract::We studied the interaction of the oculomotor, cervical, and vestibular systems using a specially developed technique. A series of two tests were performed on 26 healthy subjects and 42 patients with stages I-II Parkinson's disease receiving and not receiving treatment. In coordinated tests, all amplitude-time characte...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1443-4

    authors: Shvetsov AY,Ivanova EA,Chigalejchik LA,Baziyan BKh

    更新日期:2011-11-01 00:00:00

  • Regenerative reactions of the myocardium in plastic insufficiency of cardiomyocytes during ontogeny.

    abstract::Structural reorganization of the myocardium was studied in rats of various age groups (periods of progressive and regressive growth) with anthracycline-induced regenerative and plastic insufficiency. The specific features included the prevalence of cardiomyocyte lysis, diffuse and microfocal changes, and diffuse or mi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0855-x

    authors: Nepomnyashchikh LM,Molodykh NA,Lushnikova EL,Klinnikova MG,Molodykh OP

    更新日期:2009-12-01 00:00:00

  • Analgesic and antiinflammatory activity of antibodies to histamine under experimental conditions.

    abstract::Ultralow doses of antibodies to histamine in produced an antiproliferative effect on experimental animals with inflammation. Analgesic activity of antibodies to histamine was revealed on the model of acetic acid-induced writhing. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1024795116784

    authors: Krylova SG,Razina TG,Zueva EP,Amosova EN,Shilova NV,Dugina YL,Epstein OI

    更新日期:2003-01-01 00:00:00

  • Modulation of α-rhythm and autonomic status of human by color photostimulation.

    abstract::The effects of photostimulation with different colors on α-rhythm amplitude and parameters of variation pulsometry were studied. Green color stimulation modulates human functions: ?-rhythm amplitude increases by 1.06 μV/√Hz (p<0.05) and the index of regulatory systems strain decreases significantly (p<0.05). ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-1046-5

    authors: Osipova MA,Arkov VV,Tonevitsky AG

    更新日期:2010-11-01 00:00:00

  • Lipid Peroxidation-Antioxidant Defense System during Toxic Liver Damage and Its Correction with a Nanocomposite [corrected] Substance Containing Selenium and Arabinogalactan.

    abstract::Experiments on rat model of toxic liver damage (CCl4, subcutaneously) have demonstrated that selenium nanopreparation on arabinogalactan matrix and partially arabinogalactan alone prevented the development of oxidative stress assessed by the balance of LPO and antioxidant defense processes. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2928-3

    authors: Kolesnikova LI,Karpova EA,Vlasov BY,Sukhov BG,Mov BA

    更新日期:2015-06-01 00:00:00

  • NO-producing activity of macrophages infected with tick-borne encephalitis virus.

    abstract::Stimulation of NO-producing activity of macrophages infected with tick-borne encephalitis virus was demonstrated. Activity of NADPH-diaphorase, inducible NO synthase, and cytochrome oxidase, a heme-containing mitochondrial enzyme reflecting NO production by the nitrite reductase pathway was observed against the backgr...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0087-5

    authors: Plekhova NG,Somova LM,Zavorueva DV,Krylova NV,Leonova GN

    更新日期:2008-03-01 00:00:00

  • Participation of IIb-IIIa glycoprotein in spontaneous platelet aggregation.

    abstract::In some patients with stable and unstable angina pectoris and in some donors without clinical manifestations of cardiovascular diseases and other pathologies, spontaneous platelet aggregation was completely suppressed by glycoprotein IIb-IIIa antagonists blocking the interaction of this glycoprotein with fibrinogen. A...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0146-3

    authors: Sirotkina OV,Zabotina AM,Taraskina AE,Sivachenko EB,Zueva EE,Kadinskaya MI,Buryachkovskaya LI,Uchitel' IA,Khaspekova SG,Vavilova TV,Shvartsman AL,Mazurov AV

    更新日期:2007-04-01 00:00:00

  • Possible mechanism underlying the effect of Semax on the formation of indomethacin-induced ulcers in rats.

    abstract::Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers. Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented redu...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1020285909696

    authors: Zhuikova SE,Sergeev VI,Samonina GE,Myasoedov NF

    更新日期:2002-06-01 00:00:00

  • Sex-Related Differences in the Sensitivity to Carcinogenic Effect of Urethane on the Lungs in Mice Are Reversed after Neonatal Androgenization.

    abstract::Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before carcinogen challenge reduced the number of lung adenomas caused by it in males and somewhat increased the number of tumors in females. Exogenous testosterone a...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-3075-6

    authors: Morozkova TS,Kaledin VI

    更新日期:2015-10-01 00:00:00

  • Assessment of Biocompatibility and Local Action of Biomaterial for Production of an Envelope for Implanted Heart Electronic Devices.

    abstract::We studied a biomaterial for a new domestic product, a biological envelope for implantation of cardiac electronic devices. The product is designed to prevent complications after pacemaker implantation and to facilitate the reimplantation procedure. By chemical and biological processing of raw materials (submucosa of p...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04712-0

    authors: Shadrina DV,Venediktov AA,Evdokimov SV,Vaskovskii VA,Artyukhina EA,Revishvili AS,Durmanov SS,Bazylev VV

    更新日期:2020-01-01 00:00:00

  • Effects of Thermoextracts of Brucella S and L Forms on Lipid Peroxidation and Antioxidant Defense in Organs of Laboratory Animals.

    abstract::The dynamics of LPO marker malondialdehyde formation and peroxidase-destroying activity was studied in homogenized organs of guinea pigs, immunized with thermoextracts from S and L forms Brucella abortus I-206. The L form brucella thermoextract exhibited a lower reactogenicity and adequately activated the antioxidant ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4138-2

    authors: Dubrovina VI,Balakhonov SV,Yurieva OV,Starovoitova TP,Barannikova NL,Tokareva LE,Pyatidesyatnikova AB,Yastremskaya KY,Shkaruba TT

    更新日期:2018-06-01 00:00:00

  • Methodological approaches to deciphering the etiological structure of non-nosocomial pneumonia.

    abstract::Comparative analysis of the efficiency of PCR and microbiological methods for deciphering of the etiological structure of non-nosocomial pneumonias demonstrated the diagnostic significance of detecting Streptococcus pneumoniae DNA in the blood, but not sputum. Mechanisms of penetration of S. pneumoniae into the blood ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000010969.76881.87

    authors: Artemova LV,Beskhlebnaya VA,Ezhova LG,Kirillov MY,Kravtsov EG,Dalin MV

    更新日期:2003-10-01 00:00:00

  • Effects of Miramistin and Phosprenil on Microbial Biofilms.

    abstract::Effects of Miramistin and Phosprenil on biofilms of S. pyogenes, S. aureus, E. coli, L. acidophilus, and L. plantarum were studied. Significant differences in the effects of these substances on mature biofilms of microorganisms and the process of their formation were observed. Miramistin had significant inhibiting eff...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3823-x

    authors: Danilova TA,Danilina GA,Adzhieva AA,Minko AG,Nikolaeva TN,Zhukhovitskii VG,Pronin AV

    更新日期:2017-08-01 00:00:00

  • Oxidative status and citrate concentration in rat tissues during experimental hyperthyroidism and melatonin treatment.

    abstract::Biochemiluminescence increased, while aconitate hydratase activity and citrate accumulation in tissues of the liver and heart and blood decreased in rats with experimental hyperthyroidism. These changes reflect activation of free radical oxidation, damage to enzyme molecules with reactive oxygen species, and impaired ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0289-2

    authors: Popov SS,Pashkov AN,Popova TN,Zoloedov VI,Semenikhina AV,Rakhmanova TI

    更新日期:2007-08-01 00:00:00

  • Methodological aspects of optimizing the choice of plants for creation of new drugs.

    abstract::An integrative systemic model of pharmacological reaction to a phytopreparation was created as a result of conceptual structurization of facts and formalization of causal relations. The use of the new methodological approach to the choice, primary screening, and profound studies of plants for prospective addition ther...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2216-z

    authors: Mitrofanova IY,Yanitskaya AV,Butenko DV

    更新日期:2013-09-01 00:00:00

  • New Effect in Physiology of Human Nervous Muscle System.

    abstract::A new phenomenon (or paradox) consisting in higher statistical stability of samples, for example, tremorograms, in a group of different subjects than in the same subject in unchanged homeostasis. At the same time, it turns out that 15 different subjects are more similar (statistically) to each other than one person to...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04540-x

    authors: Zilov VG,Khadartsev AA,Eskov VM,Ilyashenko LK

    更新日期:2019-08-01 00:00:00

  • Macrophage-granulocyte colony-stimulating factor and fibroblast growth factor in the blood of patients with hyperlipoproteinemia.

    abstract::Solid-phase ELISA revealed increased content of macrophage-granulocyte colony-stimulating factor and basic fibroblast growth factor in the serum of hyperlipoproteinemic patients. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1023815714017

    authors: Saburova OS,Tvorogova MG,Soboleva EL

    更新日期:2003-02-01 00:00:00

  • Correction to: Comparative Analysis of the Expression of Glutathione Peroxidase and Glutathione Reductase Genes in Human Sperm after Cryopreservation.

    abstract::The second author's name should read A. Yu. Romanov. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10517-018-4152-4

    authors: Makarova NP,Romanov AY,Dolgushina NV,Parker MM,Krasnyi AM

    更新日期:2018-06-01 00:00:00

  • Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice.

    abstract::We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and beta1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nomega-nitro-L-arginine in NMRI mice. Atr...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000028115.53995.e0

    authors: Lobanov AV,Rzhevskii DI,Korshunov VA,Murashev AN

    更新日期:2004-02-01 00:00:00

  • Acute hypoxia during organogenesis affects cardiac autonomic balance in pregnant rats.

    abstract::Changes in ECG parameters were studied in pregnant rats exposed to acute hypobaric hypoxia during the period of organogenesis (gestation days 9 to 10). Rats with low, medium, and high tolerance to hypoxia exhibited pronounced autonomic nervous system imbalance, which become apparent as a loss of correlation between va...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0241-2

    authors: Maslova MV,Graf AV,Maklakova AS,Krushinskaya YV,Sokolova NA,Koshelev VB

    更新日期:2005-02-01 00:00:00

  • Changes in the concentration of tissue inhibitor of type 1 metalloproteinases in blood serum and liver of mice with CCl4-induced hepatitis.

    abstract::The concentration of tissue inhibitor of type 1 metalloproteinases in blood serum from intact CBA mice measured by enzyme immunoassay is similar to that in healthy humans. The concentration of tissue inhibitor of type 1 metalloproteinases in mouse bile was higher than in blood serum, while its concentration in liver h...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0098-7

    authors: Korolenko TA,Filatova TG,Savchenko NG,Yuz'ko YV,Goncharova IA,Alexeenko TV

    更新日期:2007-03-01 00:00:00

  • Role of interleukin-18 in destabilization of the atherosclerotic plaque in humans.

    abstract::Precise location of IL-18 in cell and tissue elements of the atherosclerotic lesions in humans and its role in destabilization of the atherosclerotic plaque were detected. The data suggested a hypothesis on indirect involvement of IL-18 in destruction of the elastic and collagen fibers in an unstable plaque due to thi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2675-x

    authors: Pigarevskii PV,Maltseva SV,Snegova VA,Davydova NG

    更新日期:2014-10-01 00:00:00

  • Changes in thyroid status of rats after prolonged exposure to low dose dichlorodiphenyltrichloroethane.

    abstract::The effect of low dose dichlorodiphenyltrichloroethane (DDT), omnipresent ecotoxicant and endocrine disruptor, on the functioning of the endocrine system is an urgent problem. We studied the effect of low dose DDT on thyroid status in rats. Rats receiving DDT in a dose of 1.890±0.086 μg/kg for 6 weeks showed increased...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2443-y

    authors: Yaglova NV,Yaglov VV

    更新日期:2014-04-01 00:00:00

  • Comparative study of immunocorrective activity of phenibut and its organic salts in experimental immunodeficiency.

    abstract::Phenibut and its derivatives normalized cellular (index of delayed-type hypersensitivity reaction) and humoral (antierythrocyte antibody titer) immunity and the lymphoproliferative processes in immunocompetent organs of animals with cyclophosphamide-induced immunosuppression. This indicates pronounced immunocorrective...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0571-6

    authors: Tyurenkov IN,Samotrueva MA

    更新日期:2009-05-01 00:00:00

  • Lymphatic region of the uterus and adnexa during pregnancy after inflammation of internal genital organs.

    abstract::We studied the course and outcome of pregnancy in the model of inflammation of internal genital organs in female rats. It was shown that inflammation of internal genital organs impairing the state of the lymphatic region of the uterus and adnexa and relationship between the drainage and detoxification function therein...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2672-0

    authors: Dergacheva TI,Borodin YI,Konenkov VI

    更新日期:2014-10-01 00:00:00