Protective effect of complex antioxidant preparation containing vitamins and amino acids in rats with burn trauma complicated by endotoxemia.

abstract：:The study examined effectiveness of pharmaco-cold cardioplegia employing solutions of enhanced buffer capacity during surgery of obstructive hypertrophic cardiomyopathy in adult patients (N=51) operated during 2013-2018. In group 1 (N=28), the cardioplegia was performed with HTK (Custodiol) solution, whereas in group ...

journal_title：Bulletin of experimental biology and medicine

authors： Bokeria LA,Egorov DN,Popov AE,Bledzhyants GA,Artyukhina TV,Movsesyan RR

更新日期：2020-07-01 00:00:00

abstract：:The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after streptozotocin inj...

journal_title：Bulletin of experimental biology and medicine

authors： Lotosh NG,Savel'eva EK,Selishcheva AA,Savel'ev SV

更新日期：2013-05-01 00:00:00

abstract：:Experiments on outbred albino rats showed that subacute poisoning with tetrachloromethane in a total dose of 1.0 LD50 appreciably decreased blood concentrations of cytokines (IFN-gamma, IL-2, IL-4, IL-6, IL-10), reduced the IFN-gamma/IL-4 ratio in comparison with the control, and suppressed the immune reactions, which...

journal_title：Bulletin of experimental biology and medicine

authors： Zabrodskii PF,Kirichuk VF,Lim VG,Balashov SV,Svistunov AA

更新日期：2009-01-01 00:00:00

abstract：:Neuroprotective effects of GABA(B) agonist baclofen and GABA(A) agonists THIP and muscimol are completely additive. GABAA and GABA(B) receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effect of two agonists with selective GABA...

journal_title：Bulletin of experimental biology and medicine

authors： Kulinskii VI,Mikhel'son GV

更新日期：2000-08-01 00:00:00

abstract：:Treadmill training of spinalized rats creates conditions for early appearance of rhythmic locomotor movements of the hind limbs. Recovery of the movements was paralleled by an appropriate structural organization of neurons in the anterior horns of the distal compartment of the spinal cord. ...

journal_title：Bulletin of experimental biology and medicine

authors： Moshonkina TR,Gilerovich EG,Fedorova EA,Avelev VD,Gerasimenko YP,Otellin VA

更新日期：2004-08-01 00:00:00

abstract：:The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to ...

journal_title：Bulletin of experimental biology and medicine

authors： Michurina SV,Ishchenko IY,Arkhipov SA,Klimontov VV,Rachkovskaya LN,Konenkov VI,Zavyalov EL

更新日期：2016-12-01 00:00:00

abstract：:Hypochlorite produced in vivo by activated neutrophils, monocytes, and macrophages modifies blood lipoproteins and intensifies free radical lipid peroxidation, which probably plays a key role in the early stages of atherosclerotic vascular damages. ...

journal_title：Bulletin of experimental biology and medicine

authors： Panasenko OM,Sergienko VI

更新日期：2001-05-01 00:00:00

abstract：:The development of experimental type II diabetes mellitus in rats was accompanied by dysfunction of inhibitory and stimulatory heterotrimeric G-proteins, components of hormone-sensitive adenylate cyclase signal system. The function of inhibitory G-proteins decreased most significantly under these conditions, which is ...

journal_title：Bulletin of experimental biology and medicine

authors： Shpakov AO,Kuznetsova LA,Plesneva SA,Bondareva VM,Guryanov IA,Vlasov GP,Pertseva MN

更新日期：2006-12-01 00:00:00

abstract：:We measured activity of angiotensin-converting enzyme in plasma and tissue of NISAG and normotensive WAG rats. In different organs of NISAG rats, activity of this enzyme did not differ from the corresponding values of WAG rats, although enzyme activity in the plasma of NISAG rats was significantly lower than that of W...

journal_title：Bulletin of experimental biology and medicine

authors： Cherkasova OP,Fedorov VI,Markel AL

更新日期：2005-10-01 00:00:00

abstract：:Antisense oligonucleotide to alpha2A-adrenoceptors increased the levels of mRNA (reverse polymerase chain reaction) and protein for a key executioner protease of apoptosis caspase-3 (immunoblotting assay) in the cerebral cortex of newborn rats. The relationship between the observed effect and low expression of alpha2-...

journal_title：Bulletin of experimental biology and medicine

authors： Men'shanov PN,Bannova AV,Il'inykh FA,Dygalo NN

更新日期：2007-03-01 00:00:00

abstract：:We studied the effects of a concentrate of metabolites of Trichoderma harzianum Rifai F-180, an active producer of L-lysine-α-oxidase, and homogenous enzyme on a highly virulent bacteria Erwinia amylovora. The producer of antitumor and antiviral Trichoderma enzyme L-lysine-α-oxidase was cultured on a processing system...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova IP,Karimova EV,Shneider YA

更新日期：2017-10-01 00:00:00

abstract：:The effect of serotoninotropic substances with positive and negative effects on serum concentrations of thyrotropic hormone, total triiodothyronine, and total thyroxin was studied in old male rats. Chronic treatment with L-tryptophan and citalopram reduced serum level of total thyroxin in old intact animals and serum ...

journal_title：Bulletin of experimental biology and medicine

authors： Masalova OO,Sapronov NS

更新日期：2009-11-01 00:00:00

abstract：:We studied the effect of μ-opioid receptor ligands on anxious and depressive behavior of rats. Intragastric administration of loperamide and methylnaloxone reduced animal anxiety evaluated by an increase in the number of entries into and time spent in open arms of the elevated plus-maze. μ-Opioid receptor agonist lope...

journal_title：Bulletin of experimental biology and medicine

authors： Sudakov SK,Bashkatova VG,Kolpakov AA,Trigub MM

更新日期：2010-09-01 00:00:00

abstract：:Viability of keratinocytes of HaCaT immortalized line incubated with sodium dodecyl sulfate for 3 min, 1 and 48 h, was studied by light microscopy, MTT test, and neutral red absorption test. The IC50 values were determined for each of the studied lengths of exposure. HaCaT cells exhibited a dose-dependent decrease of ...

journal_title：Bulletin of experimental biology and medicine

authors： Rusanov AL,Luzgina NG,Lisitsa AV

更新日期：2017-06-01 00:00:00

abstract：:Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced pluripotent stem cells was accompanied by mar...

journal_title：Bulletin of experimental biology and medicine

authors： Bobrov MY,Bezuglov VV,Khaspekov LG,Illarioshkin SN,Novosadova EV,Grivennikov IA

更新日期：2017-06-01 00:00:00

abstract：:Structural modifications of the gastric tube transplant were studied during the delayed period after esophagoplasty carried out for benign diseases of the esophagus. Adaptive and pathological reactions manifesting in atrophic and sclerotic changes in the mucosa formed the basis for transplant reorganization. The leadi...

journal_title：Bulletin of experimental biology and medicine

authors： Lapii GA,Nepomnyashchikh LM,Sudovykh IE,Kutepov AV

更新日期：2010-10-01 00:00:00

abstract：:Animals were immunized with transmissible gastroenteritis virus conjugated with gold nanoparticles. The resultant antibodies had a higher titer than antibodies produced in response to native virus. Immunization with the antigen-colloidal gold complex led to a significant increase of the peritoneal macrophages respirat...

journal_title：Bulletin of experimental biology and medicine

authors： Staroverov SA,Vidyasheva IV,Gabalov KP,Vasilenko OA,Laskavyi VN,Dykman LA

更新日期：2011-08-01 00:00:00

abstract：:Blood coagulation was enhanced and all factors (total, enzyme, and non-enzyme) of the fibrinolytic system were suppressed in rats in 60 min after forced swimming test. Argininecontaining tetrapeptide glyproline Arg-Pro-Gly-Pro administered prior to this test activated fibrinolysis and prevented hypercoagulation. Admin...

journal_title：Bulletin of experimental biology and medicine

authors： Grigor'eva ME,Lyapina LA

更新日期：2017-01-01 00:00:00

abstract：:Heart rate variability was examined in random-bred albino rats at rest. The rats were clusterized according to activity of autonomic contour of heart rate control. Combination of factor and cluster analyses enhanced informative value of spectrum parameters of the heart rate variability in nonlinear rats grouped by ini...

journal_title：Bulletin of experimental biology and medicine

authors： Kur'yanova EV,Teplyi DL,Savin VF

更新日期：2009-01-01 00:00:00

abstract：:The immunomodulatory properties of immunobiological drugs Glutoxim and Phosprenyl we well as vesicular stomatitis virus and inactivated tick-borne encephalitis vaccine virus were studied using human diploid fibroblast cell line from the collection of M. P. Chumakov Federal Research Center for Research and Development ...

journal_title：Bulletin of experimental biology and medicine

authors： Konyuschko OI,Ozherelkov SV,Vorovich MF,Ivanova AL,Sotskova SE,Ishmuhametov AA,Kozhevnikova TN,Sanin AV

更新日期：2020-12-01 00:00:00

abstract：:Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. Incubation of lymphocytes with homoc...

journal_title：Bulletin of experimental biology and medicine

authors： Vladychenskaya EA,Tyulina OV,Boldyrev AA

更新日期：2006-07-01 00:00:00

abstract：:The peculiarities of Walker 256 tumor growth depending on the dose of transplanted cells were studied in rats differing by vasopressin production. Transplantation of 10(5) cells does not lead to tumor development. The dose of 7 x 10(5) cells induces progressively growing tumors in WAG rats, while in Brattleboro rats t...

journal_title：Bulletin of experimental biology and medicine

authors： Khegay II,Popova NA,Ganilova LS,Shnyder EP,Ivanova LN

更新日期：2008-01-01 00:00:00

abstract：:Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by i...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Lin'kova NS,Polyakova VO,Kvetnoy IM,Benberin VV,D'yakonov MM,Titkov YS

更新日期：2012-08-01 00:00:00

abstract：:We demonstrated specific changes in platelet structure in different types of tuberculous process, in particular, shift in the proportion between alpha-granules, dense granules, different disorders in the mitochondrial and lysosomal apparatus, etc. The role of platelets in immune process is studied. Redistribution of a...

journal_title：Bulletin of experimental biology and medicine

authors： Khechinashvili GN,Khvitiya NG

更新日期：2004-11-01 00:00:00

abstract：:A series of short neurotoxins (molecular weight 3500-5000 D) was isolated from Vietnamese scorpion B. occitanus sp. All these toxins blocked generation of action potentials (this effect depended on their molecular weight), but did not change conduction velocity and excitation threshold of the nerve. ...

journal_title：Bulletin of experimental biology and medicine

authors： Hoang NA,Maksimov GV,Berezin BB,Piskarev VE,Yamskov IA

更新日期：2001-10-01 00:00:00

abstract：:cDNA encoding VEGF and Ig-like extracellular domains 2-4 of VEGFR-1 (sFlt-1(2-4)) were cloned into prokaryotic expression vectors pET32a and pQE60. Recombinant proteins were purified (metal affinity chromatography) and renatured. Chemiluminescent study for the interaction of recombinant VEGF and sFlt-1(2-4) showed tha...

journal_title：Bulletin of experimental biology and medicine

authors： Leopol'd AV,Baklaushev VP,Korchagina AA,Shein SA,Grinenko NF,Pavlov KA,Ryabukhin IA,Chekhonin VP

更新日期：2012-04-01 00:00:00

abstract：:We studied the influence of the characteristics of oxide porous coatings on osteogenesis and integration of new bone tissue and titanium implant surface in the ectopic osteogenesis test. Implants with coating with pore size 2-20 μ exhibit better osteogenic and osteoconductive characteristics than implants with homogen...

journal_title：Bulletin of experimental biology and medicine

authors： Nadezhdin SV,Zubareva EV,Burda YE,Kolobov YR,Ivanov MB,Khramov GV,Afanas'ev AY

更新日期：2017-04-01 00:00:00

abstract：:Influenza virus hemagglutinins are surface proteins responsible for fusion of the viral and cellular membranes. Their capacity to mediate membrane fusion (fusogenic activity) is studied by various methods, including the syncytium formation and pseudovirus transduction methods. We constructed plasmids coding for genes ...

journal_title：Bulletin of experimental biology and medicine

authors： Kononova AA,Cheresiz SV,Chechushkov AV,Razumova YV,Pokrovskii AG

更新日期：2017-11-01 00:00:00

abstract：:Plasma LDL content increased in rats with mild chronic heart failure, but decreased in animals with severe pathology. The lipid profile of β-adrenoceptor antagonists depended on their selectivity. The most selective antagonists of β-adrenoceptors had little effect on the lipid composition. Nonselective β-adrenoceptor ...

journal_title：Bulletin of experimental biology and medicine

authors： Sidorov AV

更新日期：2013-12-01 00:00:00

abstract：:We revealed a significant positive correlation between the concentrations of tissue VEGF and its receptor VEGFR2 in the primary tumor. The degree and direction of changes in the content of VEGF and VEGFR2 in cytosols of tumors from patients with locally spread breast cancer during the preoperation therapy depended on ...

journal_title：Bulletin of experimental biology and medicine

authors： Kim EA,Gershtein ES,Vysotskaya IV,Kushlinskii NE

更新日期：2008-02-01 00:00:00