Abstract：
:The concentration of tissue inhibitor of type 1 metalloproteinases in blood serum from intact CBA mice measured by enzyme immunoassay is similar to that in healthy humans. The concentration of tissue inhibitor of type 1 metalloproteinases in mouse bile was higher than in blood serum, while its concentration in liver homogenate more than 1000-fold exceeded that in the serum, which attests to its primarily intracellular localization in the liver. Loading of liver cell lysosomes with Triton WR-1339 and development of intrahepatic cholestasis did not affect the concentration of tissue inhibitor of type 1 metalloproteinases in liver homogenate and bile. Administration of CCl4 to mice for 4.5 weeks was accompanied by an increase in the concentration of tissue inhibitor of type 1 metalloproteinases in blood serum, but not in liver homogenate. These changes reflect dysregulation of metalloproteinases, development of inflammation, and progression of the initial stage of connective tissue formation in mouse liver.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Korolenko TA,Filatova TG,Savchenko NG,Yuz'ko YV,Goncharova IA,Alexeenko TVdoi
10.1007/s10517-007-0098-7subject
Has Abstractpub_date
2007-03-01 00:00:00pages
312-5issue
3eissn
0007-4888issn
1573-8221journal_volume
143pub_type
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