Abstract:
:The development of MPTP-induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain frontal cortex. Prolyl endopeptidase activity in the striatum also increased under these conditions. Our results indicate that proline-specific peptidases in the target structures of the brain dopaminergic system are involved in the pathogenesis of dopamine deficiency-dependent depressive states.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Krupina NA,Zolotov NN,Bogdanova NG,Orlova IN,Khlebnikova NN,Kryzhanovskii GNdoi
10.1007/s10517-006-0416-5subject
Has Abstractpub_date
2006-11-01 00:00:00pages
554-6issue
5eissn
0007-4888issn
1573-8221pii
doijournal_volume
142pub_type
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