Abstract：
:We studied morphological changes in the myocardium during experimental myocardial infarction in rats with different resistance to hypoxia. Microscopic examination showed that morphological changes in the ischemic zone and adjacent tissues are different in rats with high and low resistance to acute ischemia. In highly resistant rats, necrotic changes in cardiomyocytes included focal contracture and loosening. These changes were followed by the formation of focal necroses with well-defined boundaries, dense demarcation infiltrates, and pronounced hypertrophy of cardiomyocytes in the adjacent tissue. In low resistant rats, pronounced edema in the ischemia zone and numerous hemorrhages in the interstitial tissue developed in the early stage after coronary occlusion. These changes were followed by the formation of more extensive necrotic areas with diffuse boundaries, less pronounced demarcation, and irregular hypertrophy of cardiomyocytes in the surrounding tissue.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Karimov KY,Saidov AB,Israilov RIdoi
10.1023/a:1013600302382subject
Has Abstractpub_date
2001-10-01 00:00:00pages
1021-3issue
4eissn
0007-4888issn
1573-8221journal_volume
132pub_type
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