Expression of profibrotic growth factors and their receptors by mouse lung macrophages and fibroblasts under conditions of acute viral inflammation in influenza A/H5N1 virus.

Abstract:

:Morphological signs of early interstitial fibrosis, developing under conditions of acute viral inflammation (postinfection days 1-14), were observed in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The development of fibrosis was confirmed by an increase in the number of lung cells expressing TNF-α. These changes were recorded in the presence of a many-fold increase in the counts of macrophages and fibroblasts expressing FGF, EGF, and their receptors.

journal_name

Bull Exp Biol Med

authors

Anikina AG,Shkurupii VA,Potapova OV,Kovner AV,Shestopalov AM

doi

10.1007/s10517-014-2463-7

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

833-7

issue

6

eissn

0007-4888

issn

1573-8221

journal_volume

156

pub_type

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