Abstract：
:Penetration of pegylated (enveloped in polyethylene glycol) gold nanoparticles 5 and 30 nm in diameter through the placental barrier was studied in pregnant rats injected intravenously with these particles in a dose of about 0.8 mg Au/kg on day 10 of gestation. The particles were visualized in tissues by silver nitrate autometallography; the total content of gold in the fetuses was evaluated by atomic adsorption spectroscopy. Gold nanoparticles were detected in the fetal liver macrophages and in the spleens; high total content of gold in the fetuses was demonstrated for particles of both sizes. The data suggest that gold nanoparticles penetrate through rat placental barrier in vivo. No morphological changes were detected in the liver, kidneys, spleen, and brain of fetuses.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Tsyganova NA,Khairullin RM,Terentyuk GS,Khlebtsov BN,Bogatyrev VA,Dykman LA,Erykov SN,Khlebtsov NGdoi
10.1007/s10517-014-2572-3subject
Has Abstractpub_date
2014-07-01 00:00:00pages
383-5issue
3eissn
0007-4888issn
1573-8221journal_volume
157pub_type
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