Abstract:
:We studied the possibility of population of macroporous agarose cryogel sponges by mesenchymal stromal bone marrow cells with their subsequent adipogenic differentiation. After 7-day culturing of mesenchymal stromal cells in agarose cryogel, the level of cell proliferation was 35%. After 3-week culturing in a medium inducing adipogenesis we observed accumulation of intracellular neutral lipids positively stained with Oil Red O. These findings can be used for the development of bioengineering constructions of the adipose tissue on the basis of spongy carriers.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Petrenko YA,Petrenko AY,Damshkaln LG,Volkova NA,Lozinsky VIdoi
10.1007/s10517-008-0236-xsubject
Has Abstractpub_date
2008-07-01 00:00:00pages
129-32issue
1eissn
0007-4888issn
1573-8221pii
doijournal_volume
146pub_type
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abstract::The effect of streptozotocin-induced diabetes mellitus on some parameters of energy metabolism and functional status of cell membranes was studied in experiments on rats. It was found that the development of diabetes mellitus is associated with dramatic changes in the metabolism of blood cells and kidney tissue: inhib...
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pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
abstract::Crossbred CC57BR/Mv mice inherited tryptophan oxygenase gene and predisposition to alcohol consumption from parent BALB/c and C57BL mice, respectively. In CC57BR/Mv mice no relationships were found between alcohol consumption, tryptophan oxygenase activity, and single nucleotide substitutions in intron 6 of the TDO2 g...
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pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
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abstract::We proposed a mathematical model and estimated the parameters of adsorption of albumin-bilirubin complex to the surface of carbon pyropolymer. Design data corresponded to the results of experimental studies. Our findings indicate that modeling of this process should take into account fractal properties of the surface ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0491-z
更新日期:2005-09-01 00:00:00
abstract::We studied carbohydrate specificity and isotypes of antibodies to BSA-conjugated tetrasaccharide, a repeating unit of the capsular polysaccharide of Streptococcus pneumoniae serotype 14, in mouse polyclonal sera and hybridoma-synthesized products. Natural IgM antibodies to the tetrasaccharide containing epitopes simil...
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pub_type: 杂志文章
doi:10.1007/s10517-014-2463-7
更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
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abstract::Study of the expression of type IV collagen by Lewis pulmonary carcinoma cells (PLMG-T, PLMG-M1, PLMG-M2) showed that these cells produce type IV collagen. The expression of type IV collagen in PLMG-T and PLMG-M2 cells approximately 2-fold surpassed that in PLMG-M1 cells. The number of active cells (synthesizing type ...
journal_title:Bulletin of experimental biology and medicine
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journal_title:Bulletin of experimental biology and medicine
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更新日期:2013-11-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-009-0449-7
更新日期:2009-01-01 00:00:00
abstract::Alofanib is a potential allosteric inhibitor of FGFR2 used in oncology. The inhibitor blocks the extracellular part of the receptor and prevents its binding with the ligand. Alofanib suppressed proliferation of endothelial cells, their migration activity, and ability to form vessellike structures in vitro and signific...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-015-3104-5
更新日期:2015-11-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
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doi:10.1007/s10517-008-0177-4
更新日期:2008-06-01 00:00:00
abstract::An open comparative clinical study evaluated the efficiency of Proproten-100 in reliving affective, somatovegetative, behavioral, and cognitive post-withdrawal disorders and manifestations of primary pathological alcohol addiction in patients with alcohol dependence in the stage of therapeutic remission. We compared t...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2003-01-01 00:00:00
abstract::We developed a cytochrome P450 substrate-inhibitor panel for preclinical in vitro evaluation of drugs in a 3D histotypical microfluidic cell model of human liver (liver-on-a-chip technology). The concentrations of substrates and inhibitors were optimized to ensure reliable detection of the principal metabolites by HPL...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-016-3567-z
更新日期:2016-11-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
pub_type: 临床试验,杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-020-04786-w
更新日期:2020-04-01 00:00:00
abstract::The rats with neurodegenerative brain disorder induced by administration of a toxic fragment of beta-amyloid demonstrate weakened endothelium-dependent dilation of cerebral vessels, which attested to impaired production of endothelial NO. At the same time, toxic beta-amyloid fragment induced the formation of NO depots...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-006-0318-6
更新日期:2006-08-01 00:00:00
abstract::Muramyl dipeptide β-heptylglycoside (C7MDP) was administered to non-pregnant CBA female mice and pregnant mice after non-abortion-prone mating (CBA×BALB/c) and mating associated with a high rate of spontaneous abortion (CBA×DBA/2). In non-pregnant females, C7MDP increased the production of IL-2, IL-4, IL-5, IL-6, IL-1...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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