Immunostimulatory effect of gold nanoparticles conjugated with transmissible gastroenteritis virus.

abstract：:A test system developed by the authors was used to measure serum concentrations of soluble Fas in patients with malignant and benign tumors of different location and morphology. Relationships between soluble Fas levels and the main clinical and morphological characteristics of cancer were evaluated. It is proven that ...

journal_title：Bulletin of experimental biology and medicine

authors： Abbasova SG,Vysotskii MM,Ovchinnikova LK,Obusheva MN,Digaeva MA,Britvin TA,Bahoeva KA,Karabekova ZK,Kazantzeva IA,Mamedov UR,Manuchin IB,Davidov MI

更新日期：2009-10-01 00:00:00

abstract：:We studied morphological changes in the myocardium during experimental myocardial infarction in rats with different resistance to hypoxia. Microscopic examination showed that morphological changes in the ischemic zone and adjacent tissues are different in rats with high and low resistance to acute ischemia. In highly ...

journal_title：Bulletin of experimental biology and medicine

authors： Karimov KY,Saidov AB,Israilov RI

更新日期：2001-10-01 00:00:00

abstract：:Taurine is an important endogenous agonist of glycine receptors (GlyR). Using the patchclamp technique, we measured chloride current induced by a short (600 msec) application of taurine (ITau) on isolated rat pyramidal neurons. pH of taurine solution in the applicator pipette was neutral (7.4) or acidic (7.0-5.0). App...

journal_title：Bulletin of experimental biology and medicine

authors： Solntseva EI,Bukanova YV,Kondratenko RV,Skrebitsky VG

更新日期：2019-06-01 00:00:00

abstract：:We studied the formation and cytophysiological characteristics of polynuclear macrophages in primary cultures of peritoneal cells from C57Bl/6 mice. Production of reactive oxygen species and phagocytic activity in polynuclear macrophages were higher than in mononuclear macrophages. The formation of polynuclear macroph...

journal_title：Bulletin of experimental biology and medicine

authors： Arkhipov SA,Shkurupiy VA,Ijine DA,Ignatovich NV,Akhromenko ES,Arkhipova VV

更新日期：2008-12-01 00:00:00

abstract：:Acute experiments on cats showed that dynorphin A(1-13) modulates pulse activity of afferent neurons and interneurons in the bulbar cardiovascular center against the background of stable blood pressure. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhailova SD,Vasil'eva TV,Semushkina TM,Storozhakov GI

更新日期：2003-01-01 00:00:00

abstract：:Correlation between changes in activity of intracellular Ca(2+)-activated proteinases and cholesterol content in mussels in response to changes in habitat saltiness was detected in mollusks from littoral and sublittoral White sea zones. Calpain activity in mussels decreased in low water saltiness and increased in high...

journal_title：Bulletin of experimental biology and medicine

authors： Kyaivyaryainen EI,Nefedova ZA,Bondareva LA,Alekseeva NN,Nemova NN

更新日期：2005-10-01 00:00:00

abstract：:Function of sarcoplasmic reticulum was studied in rat papillary muscles treated with amiodarone. An extra stimulus (0.5 Hz) was delivered to the muscle 0.225 sec after application of a regular stimulus. Postextrasystolic potentiation was evaluated in control myocardial samples and samples treated with amiodarone. The ...

journal_title：Bulletin of experimental biology and medicine

authors： Afanas'ev SA,Lukavskaya IA,Kandinskii ML,Medvedev MA

更新日期：2002-03-01 00:00:00

abstract：:The hypolipidemic effect of Kwai, a preparation based on garlic powder (Allium sativum), depended on the initial content of cholesterol and/or triglycerides. This effect was most pronounced in patients with coronary heart disease with initial cholesterol >7.0 mmol/liter and triglyceride >1.92 mmol/liter. After treatme...

journal_title：Bulletin of experimental biology and medicine

authors： Chernyad'eva IF,Shil'nikova SV,Rogoza AN,Kukharchuk VV

更新日期：2003-05-01 00:00:00

abstract：:Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. Incubation of lymphocytes with homoc...

journal_title：Bulletin of experimental biology and medicine

authors： Vladychenskaya EA,Tyulina OV,Boldyrev AA

更新日期：2006-07-01 00:00:00

abstract：:We studied the effects of dopamine D1/D2 receptor antagonists on the dynamics of acquisition and extinction of active avoidance responses and open field behavior in ovariectomized female rats. Dopamine D1 receptor antagonist SCH-23390 (0.1 mg/kg intraperitoneally) and dopamine D2 receptor antagonist sulpiride (10.0 mg...

journal_title：Bulletin of experimental biology and medicine

authors： Fedotova YO,Sapronov NS

更新日期：2014-03-01 00:00:00

abstract：:We studied multipotent mesenchymal stromal cells isolated from the bone marrow of young (1 month) and old (>12 months) rats. The cell cultures derived from old rats were characterized by lower cell yield in the primary culture, lower number of doublings, and reduced colony-forming capacity of precursor cells. ...

journal_title：Bulletin of experimental biology and medicine

authors： Valyushina MP,Buravkova LB

更新日期：2013-05-01 00:00:00

abstract：:Electrophysiological parameters of true pacemakers in the sinoatrial node of rat heart were recorded intracellularly using glass microelectrodes. In 11 of 13 experiments acetylcholine in increasing doses did not induce migration of the dominant pacemaker region, while in two cases its minor migration upstream the sinu...

journal_title：Bulletin of experimental biology and medicine

authors： Sutyagin PV,Kalinina EE,Pylaev AS

更新日期：2004-08-01 00:00:00

abstract：:We studied the interaction between the sympathetic and parasympathetic parts of the autonomic nervous system in the regulation of smooth muscles in the femoral artery and trachea. It was shown that this regulation involves ganglionic serotoninergic neurons transmitting excitation to 5-HT, receptors in the effector tis...

journal_title：Bulletin of experimental biology and medicine

authors： Lazebnik LB,Lychkova AE

更新日期：2006-01-01 00:00:00

abstract：:Changes in the muscular tissue after subcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and additionally stained with cell membrane dye Vybrant CM-Dil in the projection of ligated femoral vein were studied by light microscopy with luminescence. Stromal cell...

journal_title：Bulletin of experimental biology and medicine

authors： Maiborodin IV,Morozov VV,Anikeev AA,Maslov RV,Figurenko NF,Matveeva VA,Maiborodina VI

更新日期：2018-03-01 00:00:00

abstract：:The study compared the effects of phytococktail Bioritm-E (a multicomponent phytoadaptogen) and experimental preparation Skvaakan from the liver of Black Sea spurdog on systemic homeostasis, microcirculation, and blood lipid profile in 15 days of their daily administration. Skvaakan enhanced the platelet activity prod...

journal_title：Bulletin of experimental biology and medicine

authors： Datieva FS,Khetagurova LG

更新日期：2012-12-01 00:00:00

abstract：:Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia. In intact animals, the level of lipid hydroperoxides in the frontal lobes of both hemispheres was by 36% higher than in other cortical areas, while total antioxid...

journal_title：Bulletin of experimental biology and medicine

authors： Fedorova TN,Devyatov AA,Berezhnoi DS,Stvolinskii SL,Morozova MP,Gavrilova SA,Tutelyan VA

更新日期：2018-10-01 00:00:00

abstract：:We studied anticonvulsant effects of combined treatment with citicoline, a nootropic substance with neuroregenerative and neuroprotective activities, and valproate, an antiepileptic agent widely used in the treatment of epilepsy, on the model of pentylenetetrazole-induced (75 mg/kg, intraperitoneally) acute generalize...

journal_title：Bulletin of experimental biology and medicine

authors： Karpova MN,Kuznetsova LV,Zin'kovskii KA,Klishina NV

更新日期：2016-02-01 00:00:00

abstract：:We studied the effects of stress exposure during the adolescent period of development (SAPD) on the parameters of inflammatory painful response and the level of depression-like behavior in prenatally stressed adult male rats. In addition, we analyzed the effects of selective serotonin (5-HT) reuptake inhibitor fluoxet...

journal_title：Bulletin of experimental biology and medicine

authors： Butkevich IP,Mikhailenko VA

更新日期：2020-07-01 00:00:00

abstract：:The efficiency of drug therapy should be evaluated by not only its directed action on specific organ or target parameter, but also its effects on general regulatory and adaptive status. ...

journal_title：Bulletin of experimental biology and medicine

authors： Pokrovskii VM,Kompaniets OG

更新日期：2008-06-01 00:00:00

abstract：:Noopept, a peptide analog of piracetam, enhanced phagocytic activity of mouse peritoneal macrophages, stimulated humoral and cellular immune response to various antigens, and markedly increased spontaneous proliferative activity of splenocytes. In animals with secondary immune deficiency caused by cyclophosphamide, no...

journal_title：Bulletin of experimental biology and medicine

authors： Kovalenko LP,Shipaeva EV,Alekseeva SV,Pronin AV,Durnev AD,Gudasheva TA,Ostrovskaja RU,Seredenin SB

更新日期：2007-07-01 00:00:00

abstract：:Experiments on rats showed that blockade of hyperpolarization-activated currents moderates tachycardia induced by beta-adrenoceptor agonist isoproterenol and potentiates the increase in stroke volume produced by this agonist. Electrical stimulation of the vagus nerve against the background of isoproterenol treatment a...

journal_title：Bulletin of experimental biology and medicine

authors： Zefirov TL,Ziyatdinova NI,Gainullin AA,Zefirov AL

更新日期：2002-05-01 00:00:00

abstract：:We performed a comparative study of the cytotoxicity of cisplatin, JM216 complex, and aminonitroxyl platinum(IV) complexes for HeLa cells grown in monolayer and 3D culture. The growth dynamics of spheroids was studied and optimal conditions for evaluation of cytotoxicity were determined. Spheroids were less sensitive ...

journal_title：Bulletin of experimental biology and medicine

authors： Trigub ММ,Filatova NV,Areshidze DА,Sen' VD,Terentiev АА

更新日期：2020-02-01 00:00:00

abstract：:The kinetics of thrombin inhibition by irons ions was studied in the thrombin time test with normal plasma. The kinetic and concentration characteristics for recovery of thrombin activity by desferal were evaluated at various periods of thrombin incubation with iron ions. The thrombin time test showed that incubation ...

journal_title：Bulletin of experimental biology and medicine

authors： Azizova OA,Shvachko AG,Aseichev AV

更新日期：2009-11-01 00:00:00

abstract：:Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene w...

journal_title：Bulletin of experimental biology and medicine

authors： Ivanova SA,Filipenko ML,Vyalova NM,Voronina EN,Pozhidaev IV,Osmanova DZ,Ivanov MV,Fedorenko OY,Semke AV,Bokhan NA

更新日期：2016-03-01 00:00:00

abstract：:The cytotoxic effects of human blood serum were studied under normal and pathological conditions. The contribution of the complement system to the realization of this effect was demonstrated. Significant differences in the serum capacity to kill foreign cells were detected for healthy subjects and asthmatics. Bovine s...

journal_title：Bulletin of experimental biology and medicine

authors： Arkhipova EN,Cherepov AB,Medvedeva YS,Alchinova IB,Karganov MY

更新日期：2012-09-01 00:00:00

abstract：:hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic ch...

journal_title：Bulletin of experimental biology and medicine

authors： Molodykh OP,Nepomnyashchikh LM,Lushnikova EL,Klinnikova MG

更新日期：2000-09-01 00:00:00

abstract：:The incidence of mutations in the BRCA1 and BRCA2 genes in the studied sampling of 74 patients with ovarian cancer was 19%. The incidence of mutations in the Russian sampling of patients, formed without consideration for the family history, is one of the highest in European countries. Retrospective analysis showed tha...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova TY,Pospekhova NI,Lyubchenko LN,Tjulandin SA,Gar'kavtseva RF,Ginter EK,Karpukhin AV

更新日期：2007-07-01 00:00:00

abstract：:We studied the course and outcome of pregnancy in the model of inflammation of internal genital organs in female rats. It was shown that inflammation of internal genital organs impairing the state of the lymphatic region of the uterus and adnexa and relationship between the drainage and detoxification function therein...

journal_title：Bulletin of experimental biology and medicine

authors： Dergacheva TI,Borodin YI,Konenkov VI

更新日期：2014-10-01 00:00:00

abstract：:The effect of serotoninotropic substances with positive and negative effects on serum concentrations of thyrotropic hormone, total triiodothyronine, and total thyroxin was studied in old male rats. Chronic treatment with L-tryptophan and citalopram reduced serum level of total thyroxin in old intact animals and serum ...

journal_title：Bulletin of experimental biology and medicine

authors： Masalova OO,Sapronov NS

更新日期：2009-11-01 00:00:00

abstract：:Alofanib is a potential allosteric inhibitor of FGFR2 used in oncology. The inhibitor blocks the extracellular part of the receptor and prevents its binding with the ligand. Alofanib suppressed proliferation of endothelial cells, their migration activity, and ability to form vessellike structures in vitro and signific...

journal_title：Bulletin of experimental biology and medicine

authors： Khochenkov DA,Solomko ES,Peretolchina NM,Ryabaya OO,Stepanova EV

更新日期：2015-11-01 00:00:00