Abstract：
:We studied the possibility of modification of hematotropic effects of granulocytic CSF and hyaluronidase. It was found that hyaluronidase in a dose of 20 U/mouse potentiates the specific effect of granulocytic CSF on granulocytopoiesis, while granulocytic CSF potentiates the stimulating effect of the enzyme on the erythroid stem. Functional activity of hemopoiesis precursors, secretion of humoral factors by adherent myelokaryocytes, and serum content of hemopoietins increased under these conditions. Hyaluronidase (100 U/mouse) against the background of treatment with granulocytic CSF leads to uncoupling of proliferation and differentiation of hemopoietic cells and abolishes the mutually activating hematotropic effect of preparations.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Goldberg ED,Dygai AM,Zyuz'kov GN,Zhdanov VVdoi
10.1007/s10517-008-0177-4subject
Has Abstractpub_date
2008-06-01 00:00:00pages
682-7issue
6eissn
0007-4888issn
1573-8221pii
doijournal_volume
145pub_type
杂志文章abstract：:We studied a combined effect of subcomponents of vitamin B complex on the growth, development, and death of human embryonic brain-derived cells (E90) cultured using a modified method of Matson. Cell death was detected by trypan blue staining. According to our results, vitamin B-complex in low-doses promote the develop...
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