Abstract：
:Cytochrome p450-mediated metabolism of GRS (indolinone antiaggregant) and its effects on activities of cytochrome p450 isoenzymes were studied. Inhibition of 6 isomers of cytochrome p450 in human liver microsomes was studied with the use of specific substrates. It was found that human liver cytochrome p450 enzymes could not induce degradation of GRS and that GRS was not an inductor or inhibitor of cytochrome p450 family members 1A2, 2C9, 2C19, 2D6, 2C8, and 3A4. Hence, clinical use of the prospective antiaggregant would not involve the risk of uncontrolled fluctuations in GRS concentrations in the organism because of interactions between the drugs.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Bykov VV,Leonov KA,Serebrov VY,Chernysheva GA,Smol'yakova VI,Solov'ev MA,Udut EV,Fisenko VP,Udut VVdoi
10.1007/s10517-020-04792-ysubject
Has Abstractpub_date
2020-04-01 00:00:00pages
739-742issue
6eissn
0007-4888issn
1573-8221pii
10.1007/s10517-020-04792-yjournal_volume
168pub_type
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