Effect of long-term treatment with β-adrenoceptor antagonists on blood lipid composition and survival of rats with heart failure of different severity.

Abstract:

:Plasma LDL content increased in rats with mild chronic heart failure, but decreased in animals with severe pathology. The lipid profile of β-adrenoceptor antagonists depended on their selectivity. The most selective antagonists of β-adrenoceptors had little effect on the lipid composition. Nonselective β-adrenoceptor antagonists increased the index of plasma atherogenicity, which did not depend on the severity of a pathological process. In mild chronic heart failure, these changes were associated with a decrease in HDL concentration, while in severe chronic heart failure; they were related to a tendency towards a decrease in HDL content and an increase in LDL concentration. The increase in survival rate was associated with true antagonism of the agent to β-adrenoceptors (the absence of intrinsic sympathomimetic activity) and, to a lesser extent, with nonselective blockade of β-adrenoceptors.

journal_name

Bull Exp Biol Med

authors

Sidorov AV

doi

10.1007/s10517-013-2312-0

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

209-12

issue

2

eissn

0007-4888

issn

1573-8221

journal_volume

156

pub_type

杂志文章
  • Regulatory role of nitric oxide in neutrophil apoptosis.

    abstract::Apoptosis of blood neutrophils from healthy donors was studied under conditions of cell culturing with different concentrations of H(2)O(2), selective NO synthase inhibitor, and inductor of NO synthesis (L-arginine). In vitro incubation of neutrophilic leukocytes with 5 mM H(2)O(2) led to activation of the apoptotic p...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0386-5

    authors: Stepovaya YA,Zhavoronok TV,Starikov YV,Bychkov VA,Chasovskih NY,Starikova YG,Petina GV,Novitsky VV,Ryazantseva NV

    更新日期:2008-12-01 00:00:00

  • Experimental study of the functional morphology of the kinetochore in mitosis.

    abstract::Chinese hamster cells in culture were blocked in prometaphase by the addition of chloral hydrate. After 2 h the chloral hydrate was removed and the ultrastructural changes in the kinetochore studied during recovery of mitosis. The kinetochore in the blocked cells is a disc measuring 300-350 nm in diameter and 30-35 nm...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/BF00799327

    authors: Alov IA,Lyubskii SL

    更新日期:1975-01-01 00:00:00

  • Effect of Erysod (erythrocyte superoxide dismutase) on blood concentration of reactive oxygen species in patients with severe burns and burn shock.

    abstract::The dynamics of blood concentrations of reactive oxygen species and LPO products in patients with thermal injuries of different severity was studied. Monitoring of these parameters by chemiluminescent and spectrophotometric techniques helps to predict the course of burn shock and prevent complications. Erysod (0.004% ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1022638213724

    authors: Churilova IV,Zinov'ev EV,Paramonov BA,Drozdova YI,Sidel'nikov VO,Chebotarev VY

    更新日期:2002-11-01 00:00:00

  • Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.

    abstract::We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locom...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1256-5

    authors: Surina NM,Kalinina TS,Volkova AV,Malikova LA,Poletaeva II,Rayevsky KS,Fedotova IB

    更新日期:2011-05-01 00:00:00

  • Experimental study of hepatoprotective activity of hydroxymethyluracil.

    abstract::Hepatoprotective activity of pyrimidine derivative hydroxymethyluracil was studied on the model of acute paracetamol-induced liver damage in rats. Hydroxymethyluracil was shown to produce a strong hepatoprotective effect. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0183-y

    authors: Mirsaev TR

    更新日期:2007-05-01 00:00:00

  • Cardiac Body Surface Potentials in Rats with Experimental Pulmonary Hypertension during Ventricular Depolarization.

    abstract::The spatial and the amplitude-temporal parameters of cardiac body surface potentials were examined in female Wistar rats with experimental pulmonary hypertension during ventricular depolarization. The cardiac body surface potentials have been led from 64 subcutaneous electrodes evenly distributed across the chest surf...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3531-y

    authors: Suslonova OV,Smirnova SL,Roshchevskaya IM

    更新日期:2016-11-01 00:00:00

  • Heart Rhythm Disturbances Caused by Injection of Cholinesterase Inhibitor Physostigmine to Rats during the Early Ontogeny.

    abstract::Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly differed by the magnit...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4095-9

    authors: Sizonov VА,Dmitrieva LE

    更新日期:2018-05-01 00:00:00

  • Model for alternative splicing of insulin receptor in myotonic dystrophy type 1.

    abstract::Muscular dystrophy is a common multisystem disease, which results from the impairment of alternative splicing. An increase in the number of unstable CTG and CCTG repeats in untranslated regions of the DMPK and ZNF9 genes is followed by dysregulation of RNA-binding proteins. Further changes are followed by dysfunction ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0611-2

    authors: Tonevitsky EA,Trushkin EV

    更新日期:2009-06-01 00:00:00

  • Models of reactions of human heart as nonlinear dynamic system to cosmic and geophysical factors.

    abstract::The paper analyzes theoretical models of the adaptive modes of generation and stability of human heart as a nonlinear point source. The analysis encompasses only ECG time-domain dynamics. To solve the general problem of the study of the adaptive changes of the cardiosignal under the action of external periodic force a...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0977-1

    authors: Pipin VV,Ragulskaya MV,Chibisov SM

    更新日期:2010-10-01 00:00:00

  • Changes in heart rate of rats subjected to treadmill training.

    abstract::The mechanisms of extracardiac regulation of heart rate were studied in rats subjected to muscle training on a treadmill with different slope angle (0 degrees , 5.5 degrees up, and 5.5 degrees down). Muscle training on a treadmill sloping down was optimal for the development of training bradycardia in 70-day-old rats....

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0361-1

    authors: Abzalov RA,Ryabysheva SS

    更新日期:2008-11-01 00:00:00

  • Modeling of Focal Seizures with Automatisms in Rats with Pendulum Movements.

    abstract::Phenotypical study was carried out in rats with pendulum movements. The animals exhibited a high level of abortive seizures in response to audiogenic stimuli and longer postictal catalepsy in comparison with those in Wistar population. Seizure severity positively correlated with the duration of poststimulus catalepsy ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04695-7

    authors: Alekhina TA,Kozhemyakina RV

    更新日期:2019-12-01 00:00:00

  • Local Treatment of Local Staphylococcal Infection with Complex Preparations Based on Metal Nanoparticles in the Experiment.

    abstract::Antibacterial activity of powdered preparations based on copper and silver nanoparticles was compared with activity of the reference preparation Baneocin on the model of local staphylococcal infection in white rats. The developed preparations exhibited pronounced antibacterial activity against methicillin-resistant S....

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04622-w

    authors: Babushkina IV,Mamonova IA,Ulyanov VY

    更新日期:2019-10-01 00:00:00

  • Immunoprotective effects of prolactin during stress-induced immune dysfunction.

    abstract::We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensiti...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000042707.46061.5d

    authors: Fomicheva EE,Nemirovich-Danchenko EA,Korneva EA

    更新日期:2004-06-01 00:00:00

  • Diagnostics of Early Changes in the Immune System Due to Low Concentration of N-Nitrosamines in the Blood.

    abstract::The concentration of N-nitrosamines (N-nitrosodimethylamine and N-nitrosodiethylamine) was measured in blood samples from children after consumption of drinking water with high content of nitrates (main group) or water meeting health standards (reference group). N-nitrosodimethylamine level in the blood from children ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-3984-2

    authors: Zaitseva NV,Ulanova TS,Dolgikh OV,Nurislamova TV,Mal'tseva OA

    更新日期:2018-01-01 00:00:00

  • Relationship between changes in the photoperiod and proliferation of Ehrlich ascitic tumor cells.

    abstract::The effect of changed photoperiod (constant darkness) on the proliferation of Ehrlich ascitic tumor cells was demonstrated. Some mechanisms maintaining the proliferative homeostasis in Ehrlich ascitic tumor under conditions of constant darkness were studied, explaining more leveled pattern of circadian rhythms of cell...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0356-5

    authors: Mashanova OG,Romanov YA,Evstafev VV,Semenova MV

    更新日期:2005-05-01 00:00:00

  • Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.

    abstract::The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intrap...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3544-6

    authors: Kolik LG,Nadorova AV,Seredenin SB

    更新日期:2016-11-01 00:00:00

  • Comparative characteristics of lipemia models induced by injections of Triton WR-1339 and poloxamer 407 in mice.

    abstract::Lipemia modeled by injections of Triton WR-1339 (500 mg/kg) and poloxamer 407 (500 mg/kg) to mice were compared. LP fraction and subfraction compositions were compared by small-angle X-ray scattering on a diffractometer. Both compounds in the same dose caused a sharp increase in serum concentrations of total cholester...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2133-1

    authors: Loginova VM,Tuzikov FV,Tuzikova NA,Korolenko TA

    更新日期:2013-06-01 00:00:00

  • Behavioral Indexes of Thermal Nociceptive Sensitivity in Rats after Melatonin Administration.

    abstract::We studied the effect of melatonin (10 mg/kg intraperitoneally) on behavioral indexes reflecting changes in nociceptive sensitivity of rats in response to thermal stimulation in the hot plate test. Administration of melatonin to animals suppressed the perceptual component of nociception, which was manifested in an inc...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-3121-4

    authors: Zhuravlev BV,Murtazina EP,Pertsov SS

    更新日期:2015-12-01 00:00:00

  • Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny.

    abstract::Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormon...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3701-6

    authors: Arutyunyan AV,Zaloznyaya IV,Kerkeshko GO,Milyutina YP,Korenevskii AV

    更新日期:2017-04-01 00:00:00

  • Metabolism of a New Antiaggregant, Indolinone Derivative.

    abstract::Cytochrome p450-mediated metabolism of GRS (indolinone antiaggregant) and its effects on activities of cytochrome p450 isoenzymes were studied. Inhibition of 6 isomers of cytochrome p450 in human liver microsomes was studied with the use of specific substrates. It was found that human liver cytochrome p450 enzymes cou...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04792-y

    authors: Bykov VV,Leonov KA,Serebrov VY,Chernysheva GA,Smol'yakova VI,Solov'ev MA,Udut EV,Fisenko VP,Udut VV

    更新日期:2020-04-01 00:00:00

  • Morphometric and histochemical characteristics of the neocortex and hippocampus of experimentally enlarged rat brain during the suckling period of ontogeny.

    abstract::Enlargement of the brain weight was attained in rats by reducing the number of neonates in the litter. The brain of 14- and 30-day-old animals was examined (controls: intact animals from litters of average numbers). Difference between the brain weight at 14 and 30 days was about 200 mg. The parameter in the experiment...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1884-4

    authors: Ryzhavskii BY,Litvintseva EM

    更新日期:2012-11-01 00:00:00

  • Evaluation of the vitamin status in nursing women by vitamin content in breast milk.

    abstract::The dependence of daily vitamin excretion with breast milk on dietary vitamin content and blood vitamin level was studied in nursing women. Breast mils vitamins were assayed in women supplied with vitamins. We identified the criteria for adequate vitamin supply in nursing women over the 1st month after labor (vitamins...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0161-9

    authors: Kodentsova VM,Vrzhesinskaya OA

    更新日期:2006-03-01 00:00:00

  • Possible Recovery of Manifestation of Prolactin Receptor and Some of Its Target Proteins in the Liver and Kidney Cells of Female Rats after Relief of Cholestasis Complicated and Not Complicated by Hyperprolactinemia.

    abstract::Immunohistochemistry with semi-quantitative analysis of computer images showed that prolactin receptor and cystic fi brosis transmembrane regulator (CFTR) in cholangiocytes of female rats elevated in cholestasis quickly respond to its relief. The effect of hyperprolactinemia on the extent of return of these proteins t...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2963-0

    authors: Aleksandrova MI,Sirotina NS,Smirnova OV

    更新日期:2015-07-01 00:00:00

  • Effect of tissue phospholipid composition on synergistic interactions between sympathetic and parasympathetic systems.

    abstract::The content of phospholipids in various tissues was studied during synergistic interaction between two branches of the autonomic nervous system. We found higher myocardial content of choline-containing phospholipids and lower rigidity of erythrocyte membranes in rabbits with pronounced sympathetic potentiation of the ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1016203713719

    authors: Lychkova AE,Smirnov VM

    更新日期:2002-04-01 00:00:00

  • Experimental models for culturing of eye tissues of Pleurodeles waltl for evaluation of specific effects of sclera bioregulator in ultra-low doses.

    abstract::Experiments on stationary culture of posterior eye and roll-bottle culture of the whole eye from adult water lizards Pleurodeles waltl showed that sclera bioregulator produces a stabilizing effects on adhesion interactions between the sclera, choroid, and pigment epithelium and on the maintenance of viability of scler...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0957-5

    authors: Yamskova VP,Krasnov MS,Skripnikova VS,Yamskov IA

    更新日期:2010-10-01 00:00:00

  • Allotransplantation of pituitary cells to rat testicle.

    abstract::Fifty-three transplantations of pituitary tissue (intact and minced with scissors) under the tunica albuginea testis were carried out. In both series pituitary cells retained viability for up to 6 months. Transplantation of cell suspension was not accompanied by the formation of necrotic zone in the transplant; the ad...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1017543912512

    authors: Dendeberov ES

    更新日期:2001-02-01 00:00:00

  • Participation of IIb-IIIa glycoprotein in spontaneous platelet aggregation.

    abstract::In some patients with stable and unstable angina pectoris and in some donors without clinical manifestations of cardiovascular diseases and other pathologies, spontaneous platelet aggregation was completely suppressed by glycoprotein IIb-IIIa antagonists blocking the interaction of this glycoprotein with fibrinogen. A...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0146-3

    authors: Sirotkina OV,Zabotina AM,Taraskina AE,Sivachenko EB,Zueva EE,Kadinskaya MI,Buryachkovskaya LI,Uchitel' IA,Khaspekova SG,Vavilova TV,Shvartsman AL,Mazurov AV

    更新日期:2007-04-01 00:00:00

  • Mitral and Aortic Valvulitis in Primary Chronic Septic Endocarditis.

    abstract::Results of long-term prospective follow-up of patients with early stages of mitral and aortic valvulitis and primary chronic septic endocarditic are presented. Clinical diagnostics of the diseases is described and the key role is assigned to pathognomic (absolute) clinical symptoms. The tendency to progressive fibrosi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2878-9

    authors: Bushmanova GM,Zorina IG,Nikityuk DB,Nepomnyashchikh RD,Lapii GA,Postnikova OA,Semenov DE

    更新日期:2015-05-01 00:00:00

  • Structural changes in abdominal aorta and vena cava inferior after experimental microwave destruction.

    abstract::We studied morphological changes in rat abdominal aorta and vena cava inferior induced by endovascular microwave destruction. This treatment induced thrombosis and necrosis of the vascular walls, but fibrous framework was not completely destroyed. Then we observed irreversible changes in vessels: obliteration, atrophy...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1020633427502

    authors: Denisov-Nikol'skii YI,Shafranov VV,Borkhunova EN,Doktorov AA,Mikhaleva LM,Mikhalev AP

    更新日期:2002-07-01 00:00:00

  • Effect of epiphysectomy on the circadian dynamics of antiradical activity of chalone-antichalone system of albino rat liver.

    abstract::Antiradical activity of the chalone-antichalone system in the liver of albino rats is characterized by circadian rhythms. The production of tissue regulators of proliferation is synchronized with the 24-h light/darkness cycle. Active phase of the rhythm of antiradical activity falls on night hours. Epiphysectomy cause...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0289-x

    authors: Slesarev SM,Arav VI,Antohin AI,Pashkov AN

    更新日期:2008-09-01 00:00:00