Focal Unilateral Traumatic brain injury Causes Delayed Neurodegenerative Changes in the Brain of Rats.

abstract：:Induction of direct cell death is one of the mechanisms of the antitumor effect of GD2-specific antibodies used for the therapy of high-risk neuroblastoma. The mechanisms of the cytotoxic signal triggered by antibody binding to GD2 ganglioside on the surface of the tumor cell remain insufficiently studied. Using inhib...

journal_title：Bulletin of experimental biology and medicine

authors： Doronin II,Kholodenko IV,Zubareva AA,Yarygin KN,Deev SM,Kholodenko RV

更新日期：2019-02-01 00:00:00

abstract：:We developed an optimal protocol for preparing and culturing of olfactory ensheathing cells from human olfactory mucosa. Using this protocol, we obtained a culture enriched with human olfactory ensheathing cells. Immunofluorescence analysis by simultaneous expression of GFAP and p75NTR markers showed that the content ...

journal_title：Bulletin of experimental biology and medicine

authors： Voronova АD,Stepanova OV,Valikhov MP,Chadin AV,Dvornikov АS,Reshetov IV,Chekhonin VP

更新日期：2018-03-01 00:00:00

abstract：:Prostatotropic activity of (3,5-dimethyl-4-hydroxy)benzyl thiododecane (T-DD) was evaluated on a model of benign prostatic hyperplasia induced in Wistar rats by chronic (2 months) intraperitoneal administration of sulpiride (40 mg/kg). Morphometric analysis of the dorsolateral lobe of the prostate showed that after th...

journal_title：Bulletin of experimental biology and medicine

authors： Nizomov SA,Sorokina IV,Zhukova NA,Tolstikova TG,Semenov DE,Prosenko AE

更新日期：2019-10-01 00:00:00

abstract：:The peculiarities of Walker 256 tumor growth depending on the dose of transplanted cells were studied in rats differing by vasopressin production. Transplantation of 10(5) cells does not lead to tumor development. The dose of 7 x 10(5) cells induces progressively growing tumors in WAG rats, while in Brattleboro rats t...

journal_title：Bulletin of experimental biology and medicine

authors： Khegay II,Popova NA,Ganilova LS,Shnyder EP,Ivanova LN

更新日期：2008-01-01 00:00:00

abstract：:We studied daily dynamics of proliferative activity of embryonic fibroblast-like cells in culture during the logarithmic growth phase. Daily increase in cell count in the culture showed a 4-day rhythm that persisted over 3 weeks of culturing. In cultures from different animals, the phase of this rhythm was synchronous...

journal_title：Bulletin of experimental biology and medicine

authors： Diatroptova MA,Ponomarenko EA,Diatroptov ME

更新日期：2020-09-01 00:00:00

abstract：:The development of MPTP-induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain frontal cortex. Prolyl endopeptidase activity in the striatum also increased under these conditions. Our results indicate that proline-specific peptidases in the ta...

journal_title：Bulletin of experimental biology and medicine

authors： Krupina NA,Zolotov NN,Bogdanova NG,Orlova IN,Khlebnikova NN,Kryzhanovskii GN

更新日期：2006-11-01 00:00:00

abstract：:Immunohistochemical and morphometric analysis of the microcirculatory bed in the tumor and non-tumor parenchyma of the prostate was carried out with the use of endothelial cell marker CD34 in patients treated by high-intensity focused ultrasound (HIFU). The numerical density of microvessels in the adenocarcinoma focus...

journal_title：Bulletin of experimental biology and medicine

authors： Bakarev MA,Levin VP,Kachesov IV,Abdullaev NA,Neimark AI

更新日期：2018-09-01 00:00:00

abstract：:We studied the effect of anti-inflammatory cytokine IL-4 (5 μg/kg intraperitoneally) on peripheral blood leukocytes in Wistar rats with various behavioral characteristics during acute emotional stress (1-h immobilization with simultaneous subthreshold electrocutaneous stimulation). IL-4 reduced the differences in bloo...

journal_title：Bulletin of experimental biology and medicine

authors： Pertsov SS,Koplik EV,Kalinichenko LS

更新日期：2015-03-01 00:00:00

abstract：:We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of ...

journal_title：Bulletin of experimental biology and medicine

authors： Rozenfel'd SV,Togo EF,Mikheev VS,Popovich IG,Zabezhinskii MA,Anisimov VN

更新日期：2001-05-01 00:00:00

abstract：:Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explain...

journal_title：Bulletin of experimental biology and medicine

authors： Titov VN,Sazhina NN

更新日期：2014-12-01 00:00:00

abstract：:Autooxidation of low-density lipoproteins during incubation at 37 degrees C was accompanied by accumulation of LPO products, decrease in UV autofluorescence (FUV), and increase in autofluorescence in the visible band (FVIS). The degree of low-density lipoprotein modification was estimated by calculating the FVIS/FUV r...

journal_title：Bulletin of experimental biology and medicine

authors： Aidyraliev RK,Azizova OA,Vakhrusheva TV,Lopukhin YM,Mirrakhimov MM

更新日期：2006-10-01 00:00:00

abstract：:We studied the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia before and after treatment with simvastatin. Individual phospholipids were separated by thin-layer chromatography on glass plates coated with silica gel. It was found that apart from hypolipidemic effect, simvast...

journal_title：Bulletin of experimental biology and medicine

authors： Ozerova IN,Paramonova IV,Olfer'ev AM,Akhmedzhanov NM,Aleksandrova MA,Perova NV

更新日期：2001-08-01 00:00:00

abstract：:Transplantation of human bone marrow mesenchymal stem cells is considered as a promising therapeutic approach to the therapy of many diseases. However, the problem of possible alterations of the properties of mesenchymal stem cells during their expansion in in vitro cultures before transplantation is not solved. In ou...

journal_title：Bulletin of experimental biology and medicine

authors： Grigorian AS,Kruglyakov PV,Taminkina UA,Efimova OA,Pendina AA,Voskresenskaya AV,Kuznetsova TV,Polyntsev DG

更新日期：2010-12-01 00:00:00

abstract：:Experiments on rats showed that neurospecific protein preparations reduce the severity of neurological deficit, restore the structure of individual behavior of the animals with different hypoxia tolerance, and exert antioxidant action during chronic ischemic damage to the brain unfolding during the early and late phas...

journal_title：Bulletin of experimental biology and medicine

authors： Zarubina IV,Shabanov PD

更新日期：2016-02-01 00:00:00

abstract：:Oxidative kidney injury was compared in newborn and adult rats under conditions of ischemia/reperfusion and in experimental model of systemic inflammation induced by endotoxin (LPS of bacterial cell wall) administration. Oxidative stress in the kidney accompanied both experimental models, but despite similar oxidative...

journal_title：Bulletin of experimental biology and medicine

authors： Pevzner IB,Pavlenko TA,Popkov VA,Andrianova NV,Zorova LD,Brezgunova AA,Zorov SD,Yankauskas SS,Silachev DN,Zorov DB,Plotnikov EY

更新日期：2018-06-01 00:00:00

abstract：:Experiments on outbred albino rats showed that single intraperitoneal injection of cytochrome P-450 inhibitor 2-diethylaminoethyl-2,2-diphenylpropylacetate (SKF-525A) in a dose of 50 mg/kg before acute poisoning with 1,2-dichloroethane and trichloroethane in a dose of 1.0 LD(50), metabolized in the body to compounds w...

journal_title：Bulletin of experimental biology and medicine

authors： Zabrodskii PF,Mandych VG,Germanchuk VG

更新日期：2006-09-01 00:00:00

abstract：:We studied cardiac pumping function in the offspring of rats subjected to swimming exercise and the offspring of untrained rats. The rat pups were adapted for swimming with stepwise increasing load from day 21 to 70 life. At the age of 21 and 70 days, offspring of trained rats showed lower HR and significantly higher ...

journal_title：Bulletin of experimental biology and medicine

authors： Valeev AM,Abzalov NI,Abzalov RA,Nigmatullina RR,Abzalov RR,Nikitin AS

更新日期：2012-07-01 00:00:00

abstract：:The mechanisms of therapeutic resistance of human glioblastoma multiforme are analyzed. The authors make an attempt at systematization and scientific theoretical validation of new approaches to creation of biomedical cellular preparations, based on the oncoproteomic technologies, for personified therapy of the glial t...

journal_title：Bulletin of experimental biology and medicine

authors： Bryukhovetskii IS,Bryukhovetskii AS,Khotimchenko YS

更新日期：2015-04-01 00:00:00

abstract：:Results of long-term prospective follow-up of patients with early stages of mitral and aortic valvulitis and primary chronic septic endocarditic are presented. Clinical diagnostics of the diseases is described and the key role is assigned to pathognomic (absolute) clinical symptoms. The tendency to progressive fibrosi...

journal_title：Bulletin of experimental biology and medicine

authors： Bushmanova GM,Zorina IG,Nikityuk DB,Nepomnyashchikh RD,Lapii GA,Postnikova OA,Semenov DE

更新日期：2015-05-01 00:00:00

abstract：:Threefold administration of benz(a)pyrene in a dose of 20 mg/kg markedly stimulated biliary excretion of lysosomal enzymes from rat liver without signs of lysosomal damage. Constant light exposure induced changes attesting to functional activation of the lysosomal apparatus in liver cells and inhibited constitutive bi...

journal_title：Bulletin of experimental biology and medicine

authors： Pupyshev AB,Gutina EM,Fedina RG,Michurina SV,Shurlygina AV,Verbitskaya LV

更新日期：2005-01-01 00:00:00

abstract：:We studied changes in cerebral and central hemodynamics during active orthostatic load in 26 healthy men aging 20-26 years. Two types of central hemodynamics were revealed: progressive increase in blood pressure throughout the test (type 1) or initial blood pressure increase followed by its decrease with maximum incre...

journal_title：Bulletin of experimental biology and medicine

authors： Zabolotskikh NV

更新日期：2008-05-01 00:00:00

abstract：:Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD-H-2 by succinic semialdeyde a...

journal_title：Bulletin of experimental biology and medicine

authors： Zubovskaya AM,Ostrovskaya RU,Tsybina NM

更新日期：1975-01-01 00:00:00

abstract：:The effects of neural progenitor and hemopoietic stem cells on C6 glioma cells were studied in in vivo and in vitro experiments. Considerable inhibition of proliferation during co-culturing of glioma cells with neural progenitor cells was revealed by quantitative MTT test and bromodeoxyuridine incorporation test. Labe...

journal_title：Bulletin of experimental biology and medicine

authors： Baklaushev VP,Grinenko NF,Savchenko EA,Bykovskaya SN,Yusubalieva GM,Viktorov IV,Bryukhovetskii AS,Bryukhovetskii IS,Chekhonin VP

更新日期：2012-02-01 00:00:00

abstract：:We studied the effects of SNK-411, a new 5-pyrimidinol derivative, on serum cytokine profile of C57Bl/6 mice with Lewis lung carcinoma. The compound was injected intraperitoneally in doses of 25 and 50 mg/kg. A significant (by 3.5 times) increase in serum IL-4 content was detected in mice with tumors on day 9 of tumor...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznetsova OS,Tallerova AV,Nikitin SV,Kovalenko LP

更新日期：2016-02-01 00:00:00

abstract：:Immunophenotype of human bone marrow mesenchymal stem cells was studied after several culturing passages and after cryopreservation. Immunocytochemical analysis showed that bone marrow mesenchymal stem cells acquired homogeneity during in vitro culturing, but initially contained heterogeneous populations. ...

journal_title：Bulletin of experimental biology and medicine

authors： Lagar'kova MA,Lyakisheva AV,Filonenko ES,Volchkov PY,Rubtsova KV,Gerasimov YV,Chailakhyan RK,Kiselev SL

更新日期：2006-01-01 00:00:00

abstract：:The rates of oxyhemoglobin drop and CO(2) release in dogs with magnetized and nonmagnetized blood were compared. Stationary magnetic field enhances blood oxygen capacity by no less than 24%. A hypothesis was proposed on formation of bioxyhemoglobin molecules under the effect of magnetic field, in which hem binds two O...

journal_title：Bulletin of experimental biology and medicine

authors： Zhernovoi AI,Skorik VI,Chirukhin VA,Sharshina LM

更新日期：2001-02-01 00:00:00

abstract：:The effect of Dicarbamin preparation on hemopoiesis suppressed with cyclophosphamide was studied in animal experiments. It was shown that Dicarbamin produced a protective effect on granulocytic hemopoietic steam. This property of the preparation is determined by both protection of immature granulocytic cells at early ...

journal_title：Bulletin of experimental biology and medicine

authors： Nebolsin VE,Zhdanov VV,Zyuzkov GN,Udut EV,Khrichkova TY,Simanina EV,Stavrova LA,Miroshnichenko LA,Chaikovskiy AV,Dygai AM

更新日期：2011-01-01 00:00:00

abstract：:The interaction between recombinant soluble CD4 receptor (rsCD4) with human apolipoprotein A-I was studied by enzyme-linked immunosorbent assay. Our findings suggest that HIV-1 and human apolipoprotein A-I compete for the CD4 receptor and receptor for apoA-I. ...

journal_title：Bulletin of experimental biology and medicine

authors： Panin LE,Kostina NE

更新日期：2002-04-01 00:00:00

abstract：:Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. beta-Adrenoceptor blockers without intrinsic sympathomimetic activity n...

journal_title：Bulletin of experimental biology and medicine

authors： Fedorov VN,Sal'nikov EV,Sidorov AV,Bogatushin AV,Fateev MM

更新日期：2006-01-01 00:00:00

abstract：:The resistance of native and circulating modified low-density lipoproteins from human blood to spontaneous and polyethylene glycol-induced association was studied by recording light transmission fluctuations. Circulating modified low-density lipoproteins were less resistant to association than native low-density lipop...

journal_title：Bulletin of experimental biology and medicine

authors： Suprun IV,Mel'nichenko AA,Sobenin IA,Panasenko OM,Orekhov AN

更新日期：2004-10-01 00:00:00