Abstract：
:Preparations of I(125)-labeled monoclonal antibodies against neurospecific enolase and mouse plasma IgG1 were injected intravenously to rats immediately after unilateral occlusion of the middle cerebral artery. Radioactivity of I(125)-labeled monoclonal antibodies against neurospecific enolase in the brain tissue progressively increased, reached a maximum by the 48th hour, and remained practically unchanged after 72 h. At the same time radioactivity of labeled IgG1 in the brain tissue and radioactivity of both preparations in the blood, liver, spleen, kidneys, heart, and lungs decreased over 72 h. Selective accumulation of I(125)-labeled monoclonal antibodies against neurospecific enolase was less significant in the brain tissue of the contralateral hemisphere and cerebellum not exposed to ischemia.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Chekhonin VP,Lebedev SV,Ryabukhin IA,Petrov SV,Gurina OI,Dmitrieva TB,Volkov AI,Kashparov IA,Skoblov YSdoi
10.1007/s10517-005-0037-4subject
Has Abstractpub_date
2004-10-01 00:00:00pages
343-7issue
4eissn
0007-4888issn
1573-8221pii
doijournal_volume
138pub_type
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