Abstract:
:We studied the mechanisms of regenerative (wound healing) effects of songorine associated with functional activation of mesenchymal progenitor cells. The key role of FGF receptors on these progenitor cells in the stimulation of realization of their growth potential under the effect of the alkaloid was demonstrated. Under in vitro conditions, the antibodies to FGF receptor abolished the songorine-induced increase in the number of fibroblast colony-forming units in bone marrow cell culture. The intensity of differentiation of mesenchymal precursors remained unchanged.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Zyuz'kov GN,Chaikovskii AV,Ligacheva AA,Zhdanov VV,Udut EV,Danilets MG,Miroshnichenko LA,Simanina EV,Suslov NI,Losev EA,Trofimova ES,Povet'eva TN,Nesterova YV,Fomina TI,Minakova MY,Dygai AMdoi
10.1007/s10517-014-2511-3subject
Has Abstractpub_date
2014-05-01 00:00:00pages
146-9issue
1eissn
0007-4888issn
1573-8221journal_volume
157pub_type
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