In vivo anticancer activity of lysates from trypanosoma cruzi of different genetic groups.

Abstract:

:Lyzed epimastigotes of Trypanosoma cruzi clones P209-1, Gamba1, Sp104-1, MASu, Y7/1, MN12, Cl-Brener, 86/2036, Y7/2-1 inhibit the growth of Ehrlich adenocarcinoma in mice. the tumor decreased 1.5-3 times after 12 daily injections of lysates from 15 million epimastigotes. The protective effect progressed after the injections were discontinued and depended on the dose and lysate producer clone. Trypanosoma lysates in the studied doses were nontoxic.

journal_name

Bull Exp Biol Med

authors

Batmonkh Z,Kallinikova VD,Pakhorukova LV,Kravtsov EG,Karpenko LP,Dalin MV

doi

10.1007/s10517-006-0395-6

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

470-3

issue

4

eissn

0007-4888

issn

1573-8221

pii

doi

journal_volume

142

pub_type

杂志文章
  • Models of reactions of human heart as nonlinear dynamic system to cosmic and geophysical factors.

    abstract::The paper analyzes theoretical models of the adaptive modes of generation and stability of human heart as a nonlinear point source. The analysis encompasses only ECG time-domain dynamics. To solve the general problem of the study of the adaptive changes of the cardiosignal under the action of external periodic force a...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0977-1

    authors: Pipin VV,Ragulskaya MV,Chibisov SM

    更新日期:2010-10-01 00:00:00

  • Selective antitumor activity of lymphokine-activated killer cells in vitro.

    abstract::We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tumor cells. Lymphoki...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0033-y

    authors: Zhukova OS,Lebedinskaya OV,Shubina IZh,Gerasimova GK,Karamzin AM,Kiselevskii MV

    更新日期:2007-01-01 00:00:00

  • Regulation of proteolytic activity of pepsin in rats [correction of mice] by rotating electromagnetic field.

    abstract::In experiments on Wistar rats we studied the effect of low-frequency electromagnetic field rotating in either right-handed or a left-handed sense on proteolytic activity of pepsin. The right-handed rotating field increased, while left-handed rotating field decreased pepsin activity. Possible mechanisms of these change...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0281-7

    authors: Subbotina TI,Khadartsev AA,Yashin MA,Yashin AA

    更新日期:2005-03-01 00:00:00

  • Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB.

    abstract::The expression of genes for thioredoxin isoforms Trx1 and Trx2 was studied in sensitive SKOV-3 and resistant SKVLB human ovarian carcinoma cells. The development of doxorubicin resistance was accompanied by a significant increase in the expression of TRX1 gene and less pronounced increase in TRX2 gene expression. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0316-3

    authors: Kalinina EV,Chernov NN,Saprin AN,Kotova YN,Gavrilova YA,Chermnykh NS,Shcherbak NP

    更新日期:2007-09-01 00:00:00

  • Cholinergic and GABAergic innervation regulate activity of electrogenic ionic pump in earthworm somatic muscle cells.

    abstract::Carbacholine reduced, while baclofen and norepinephrine increased resting membrane potential in earthworm somatic muscle cells. In the presence of carbacholine, neither norepinephrine, nor baclofen hyperpolarized the membrane. Ouabain decreased resting potential and abolished the effects of carbacholine, norepinephrin...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0279-4

    authors: Volkov EM,Sabirova AR,Volkov ME,Zefirov AL

    更新日期:2007-08-01 00:00:00

  • Possible mechanisms underlying the effect of natural preparations on erythropoiesis under conditions of conflict situation.

    abstract::We studied the effects of various natural preparations, including extracts of Siberian ginseng, Rhodiola rosea, bergenia, and ginseng and pantohematogen on erythropoiesis under conditions of conflict situation. The test preparations were divided into 2 groups depending on their modulatory effect on intensified erythro...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1026371007993

    authors: Provalova NV,Skurikhin EG,Pershina OV,Minakova MY,Suslov NI,Dygai AM

    更新日期:2003-08-01 00:00:00

  • Infradian Rhythm in Proliferative Activity of a Culture of Embryonic Fibroblast-Like Cells from C57BL/6 Mice.

    abstract::We studied daily dynamics of proliferative activity of embryonic fibroblast-like cells in culture during the logarithmic growth phase. Daily increase in cell count in the culture showed a 4-day rhythm that persisted over 3 weeks of culturing. In cultures from different animals, the phase of this rhythm was synchronous...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04962-y

    authors: Diatroptova MA,Ponomarenko EA,Diatroptov ME

    更新日期:2020-09-01 00:00:00

  • Ultrasonic vocalization of rats in various motivational and emotional states.

    abstract::We studied the specific features of ultrasonic vocalization of Wistar rats in various motivational and emotional states. No significant changes were found in ultrasonic vocalization of rats during experimental food motivation and after the satisfaction of food requirements. The state of thirst and satisfaction of wate...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1831-4

    authors: Pertsov SS,Koplik EV,Karkishchenko NN,Sudakov KV

    更新日期:2012-10-01 00:00:00

  • Magnetic Resonance Imaging of Brain Involvement in Dogs Using Paramagnetic Contrast Enhancement with Mn(II)-DCTA P.

    abstract::Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N',N'-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infec...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3492-1

    authors: Ussov WY,Belyanin ML,Bezlepkin AI,Borodin OY,Bobrikova EE,Shimanovskii NL

    更新日期:2016-09-01 00:00:00

  • Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats.

    abstract::Single intramuscular injection of selective of NMDA receptor blocker memantine in the maximum dose of 20 mg/kg prevented the development of acute generalized tonic-clonic kainate seizures in 60% rats, but did not alleviate clonic kainate seizures and prevented chronic kainate lethality in only 30% rats. Intramuscular ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2480-6

    authors: Serdyuk SE,Gmiro VE,Veselkina OS

    更新日期:2014-05-01 00:00:00

  • Negative inotropic and chronotropic effects of delta-opioid receptor antagonists are mediated via non-opioid receptors.

    abstract::Ten-minute perfusion of intact isolated rat heart with Krebs-Henseleit solution containing delta-opioid receptor agonists (DPDPE, (-)-TAN-67) or delta-opioid receptor antagonists (naltrindole, TIPP[psi], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the r...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0188-y

    authors: Maslov LN,Lishmanov YB,Barzakh EI,Lasukova TV,Rice KK,Oeltgen PR

    更新日期:2006-04-01 00:00:00

  • Some Peculiarities of Local Distribution of Multipotent Mesenchymal Stromal Cells after Their Injection into Intact Muscle Tissue in Experiment.

    abstract::Changes in the muscular tissue after subcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and additionally stained with cell membrane dye Vybrant CM-Dil in the projection of ligated femoral vein were studied by light microscopy with luminescence. Stromal cell...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4031-z

    authors: Maiborodin IV,Morozov VV,Anikeev AA,Maslov RV,Figurenko NF,Matveeva VA,Maiborodina VI

    更新日期:2018-03-01 00:00:00

  • Mechanisms of hyperpolarizing effect of GABA on resting potential of the Lumbricus terrestris muscular wall somatic cells.

    abstract::GABA, baclofen, isoguvacine increase, and cis-4-aminocrotonic acid does not modify resting membrane potential of muscle cells. Bicuculline, phaclofen, N-ethylmaleimide, chlorpromazine, verapamil, and removal of Ca2+ from bathing solution abolished the effect of baclofen, while U73122 and D609 were ineffective in this ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0261-y

    authors: Volkov EM,Sabirova AR,Grishin SN,Zefirov AL

    更新日期:2005-02-01 00:00:00

  • Mechanisms underlying combined action of clonidine and local anesthetics.

    abstract::We studied the mechanisms of combined action of clonidine and local anesthetics amethocaine and imidazo-benzimidazole derivative RU-1117. In contrast to amethocaine, RU-1117 in therapeutic concentrations binds to imidazoline receptors and, to a lesser extent, to alpha(2A)-adrenoceptors on human platelets. Clonidine an...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1026088813307

    authors: Ponomarev VP,Galenko-Yaroshevskii AP,Dukhanin AS,Anisimova VA

    更新日期:2003-07-01 00:00:00

  • The Effect of Azithromycin on Biofilms Formation by Pathogens of Implant-Associated Infection in Large Joints.

    abstract::We studied the effect of subbacteriostatic azithromycin concentrations on the formation of microbial biofilms by Pseudomonas aeruginosa strains that caused implant-associated infection of large joints. Azithromycin in subinhibitory for planktonic cells concentrations 0.01-0.02 μg/ml stimulated biofilm formation by bot...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04982-8

    authors: Babushkina IV,Ulyanov VY,Mamonova IA,Shpinyak SP

    更新日期:2020-10-01 00:00:00

  • Effect of Interchain Disulfide Crosslinking in the Tropomyosin Molecule on Actin-Myosin Interaction in the Atrial Myocardium.

    abstract::Tropomyosin (Tpm) is one of the main regulatory proteins in the myocardium. In some heart pathologies, interchain disulfide crosslinking in the Tpm molecule occurs. In the ventricle, this change in the structural properties of the Tpm molecule affects calcium regulation of the actin-myosin interaction. Using an in vit...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04462-8

    authors: Shchepkin DV,Matyushenko AM,Bershitsky SY,Kopylova GV

    更新日期:2019-05-01 00:00:00

  • Autofluorescence of low-density lipoproteins modified as a result of autooxidation.

    abstract::Autooxidation of low-density lipoproteins during incubation at 37 degrees C was accompanied by accumulation of LPO products, decrease in UV autofluorescence (FUV), and increase in autofluorescence in the visible band (FVIS). The degree of low-density lipoprotein modification was estimated by calculating the FVIS/FUV r...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0385-8

    authors: Aidyraliev RK,Azizova OA,Vakhrusheva TV,Lopukhin YM,Mirrakhimov MM

    更新日期:2006-10-01 00:00:00

  • Resistance of native and circulating modified low-density lipoproteins in human blood to association.

    abstract::The resistance of native and circulating modified low-density lipoproteins from human blood to spontaneous and polyethylene glycol-induced association was studied by recording light transmission fluctuations. Circulating modified low-density lipoproteins were less resistant to association than native low-density lipop...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0047-2

    authors: Suprun IV,Mel'nichenko AA,Sobenin IA,Panasenko OM,Orekhov AN

    更新日期:2004-10-01 00:00:00

  • Modulation of α-rhythm and autonomic status of human by color photostimulation.

    abstract::The effects of photostimulation with different colors on α-rhythm amplitude and parameters of variation pulsometry were studied. Green color stimulation modulates human functions: ?-rhythm amplitude increases by 1.06 μV/√Hz (p<0.05) and the index of regulatory systems strain decreases significantly (p<0.05). ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-1046-5

    authors: Osipova MA,Arkov VV,Tonevitsky AG

    更新日期:2010-11-01 00:00:00

  • Free radical lipid peroxidation inhibits enzymatic conversion of beta-carotene into vitamin A.

    abstract::Free radical oxidation of arachidonic acid with soybean lipoxygenase was accompanied by inhibition of retinal synthesis from beta-carotene catalyzed by enzyme preparation from rabbit intestinal mucosa. Lipoxygenase inhibitor salicylhydroxamic acid and antioxidants suppressing free radical reactions (ethyl gallate, alp...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1017919814208

    authors: Gessler NN,Gomboeva SB,Shumaev KB,Bykhovskii VY,Lankin VZ

    更新日期:2001-05-01 00:00:00

  • Sodium Dodecyl Sulfate Cytotoxicity towards HaCaT Keratinocytes: Comparative Analysis of Methods for Evaluation of Cell Viability.

    abstract::Viability of keratinocytes of HaCaT immortalized line incubated with sodium dodecyl sulfate for 3 min, 1 and 48 h, was studied by light microscopy, MTT test, and neutral red absorption test. The IC50 values were determined for each of the studied lengths of exposure. HaCaT cells exhibited a dose-dependent decrease of ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3785-z

    authors: Rusanov AL,Luzgina NG,Lisitsa AV

    更新日期:2017-06-01 00:00:00

  • Effects of antibodies to glutamate on focal penicillin-induced epileptic activity.

    abstract::The effects of intranasal pretreatment with antibodies against glutamate on focal penicillin-induced epileptic activity were studied by recording electrocorticogram in non-anesthetized freely moving male Wistar rats. Anticonvulsant effects of intranasal administration of anti-glutamate antibodies (300 μg/kg) 1 h befor...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2206-1

    authors: Kuznetsova LV,Karpova MN,Vetrile LA,Klishina NY

    更新日期:2013-09-01 00:00:00

  • Acute hypoxia during organogenesis affects cardiac autonomic balance in pregnant rats.

    abstract::Changes in ECG parameters were studied in pregnant rats exposed to acute hypobaric hypoxia during the period of organogenesis (gestation days 9 to 10). Rats with low, medium, and high tolerance to hypoxia exhibited pronounced autonomic nervous system imbalance, which become apparent as a loss of correlation between va...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0241-2

    authors: Maslova MV,Graf AV,Maklakova AS,Krushinskaya YV,Sokolova NA,Koshelev VB

    更新日期:2005-02-01 00:00:00

  • Phenotypical Differences in Neuronal Cultures Derived via Reprogramming the Fibroblasts from Patients Carrying Mutations in Parkinsonian Genes LRRK2 and PARK2.

    abstract::Fibroblasts isolated from skin biopsy specimens from patients with genetic forms of Parkinson's disease, carriers of mutations in LRRK2 and PARK2 genes, and from a healthy volunteer were reprogrammed using lentiviral vectors into induced pluripotent stem cells (iPSC). iPSC were differentiated into neuron-like cells us...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-3072-9

    authors: Konovalova EV,Novosadova EV,Grivennikov IA,Illarioshkin SN

    更新日期:2015-10-01 00:00:00

  • High incidence of mutations in BRCA1 and BRCA2 genes in ovarian cancer.

    abstract::The incidence of mutations in the BRCA1 and BRCA2 genes in the studied sampling of 74 patients with ovarian cancer was 19%. The incidence of mutations in the Russian sampling of patients, formed without consideration for the family history, is one of the highest in European countries. Retrospective analysis showed tha...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0261-1

    authors: Smirnova TY,Pospekhova NI,Lyubchenko LN,Tjulandin SA,Gar'kavtseva RF,Ginter EK,Karpukhin AV

    更新日期:2007-07-01 00:00:00

  • Topography and affinity of calcium sensors of exo- and endocytosis in motor nerve terminals.

    abstract::Measurements with extracellular microelectrode technique showed that depolarization of motor nerve terminals in frog cutaneous pectoris muscle with high-potassium solution (40 mM K(+)) increased frequency of miniature end-plate currents. Both fast intracellular calcium chelator BAPTA-AM and slow chelator EGTA-AM equal...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0369-6

    authors: Zefirov AL,Grigor'ev PN

    更新日期:2008-12-01 00:00:00

  • Role of placenta in the regulation of fetal erythropoiesis.

    abstract::We studied erythropoiesis in newborn infants delivered by mothers with normal pregnancy and gestosis. The effects of placental extracts on hemopoiesis in JCR mice were also evaluated. Our results suggest that the placenta is involved in the regulation of fetal erythropoiesis. The placenta activates fetal erythropoiesi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1017908322856

    authors: Evseenko DA,Tsirel'nikov NI

    更新日期:2001-11-01 00:00:00

  • Structural and Functional State of Erythrocyte Membranes in Mice at Different Stages of Experimental Parkinson's Disease Induced by Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP).

    abstract::We studied some structural and functional parameters of erythrocyte membranes in mice at the late presymptomatic and early symptomatic stages of experimental Parkinson's disease induced by administration of MPTP (hemolysis, microviscosity of different regions of the lipid bilayer, LPO intensity, activity of antioxidan...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3666-5

    authors: Fatkullina LD,Molochkina EM,Kozachenko AI,Nagler LG,Burlakova EB

    更新日期:2017-03-01 00:00:00

  • Production of vascular endothelial growth factor and endothelin in the placenta and umbilical cord during normal and complicated pregnancy.

    abstract::The concentrations of vascular endothelial growth factor and endothelin in the placenta progressively increased during normal pregnancy. Production of vascular endothelial growth factor and endothelin in the placenta exceeded the normal during trimester I miscarriage and trimester III premature birth accompanied by in...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0131-2

    authors: Krukier II,Pogorelova TN

    更新日期:2006-02-01 00:00:00

  • Role of JNK and Contribution of p53 to the Realization of the Growth Potential of Mesenchymal Precursor Cells under the Effect of Fibroblast Growth Factor.

    abstract::The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of mesenchymal precursor cell function by the fibroblast growth factor was studied. The levels of fibroblast colony- and cluster formation and proliferative activity of mesenchymal precursors increased in response to J...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2997-3

    authors: Zyuz'kov GN,Zhdanov VV,Udut EV,Miroshnichenko LA,Khrichkova TY,Danilets MG,Simanina EV,Chaikovskii AV,Agafonov VI,Sherstoboev EY,Minakova MY,Burmina YV,Udut VV,Dygai AM

    更新日期:2015-08-01 00:00:00