Abstract：
:We studied some structural and functional parameters of erythrocyte membranes in mice at the late presymptomatic and early symptomatic stages of experimental Parkinson's disease induced by administration of MPTP (hemolysis, microviscosity of different regions of the lipid bilayer, LPO intensity, activity of antioxidant enzymes, and kinetic properties of acetylcholinesterase). At the presymptomatic stage, significant deviations of the studied parameters from the normal were observed; they were similar in direction and magnitude to those in humans with Parkinson's disease. At the early symptomatic stage, most parameters tended to normal. Microviscosity of bulk lipids increased at the presymptomatic stage and decreased after appearance of clinical symptoms. This dynamics probably reflects activation of compensatory mechanisms aimed at inhibition of oxidative stress triggered by the development of the pathological process.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Fatkullina LD,Molochkina EM,Kozachenko AI,Nagler LG,Burlakova EBdoi
10.1007/s10517-017-3666-5subject
Has Abstractpub_date
2017-03-01 00:00:00pages
597-601issue
5eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3666-5journal_volume
162pub_type
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