Abstract:
:The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels. Thee findings suggest a protective effect of the complex towards structural changes in the liver of mice with obesity and type 2 diabetes.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Michurina SV,Ishchenko IY,Arkhipov SA,Klimontov VV,Rachkovskaya LN,Konenkov VI,Zavyalov ELdoi
10.1007/s10517-016-3592-ysubject
Has Abstractpub_date
2016-12-01 00:00:00pages
269-272issue
2eissn
0007-4888issn
1573-8221pii
10.1007/s10517-016-3592-yjournal_volume
162pub_type
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