Serum levels of neurosteroids in patients with affective disorders.

Abstract:

:According modern biological hypotheses of the pathogenesis of affective disorders, hypothalamic-pituitary-adrenal axis dysfunction play a special role in the pathogenesis of this condition. Our study shows that the range of neuroprotective neurosteroids is gender- and nosology-dependent. Patients with affective disorders have reduced levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate; the most pronounced deficiency of neuroprotective neurosteroids is typical of patients with a single depressive episode. Reduced levels of neurosteroids producing an anabolic effect probably indicate depletion of adaptive capacities of the hypothalamic-pituitary-adrenal system in affective disorders.

journal_name

Bull Exp Biol Med

authors

Levchuk LA,Vyalova NM,Ivanova SA,Simutkin GG,Lebedeva EV,Bokhan NA

doi

10.1007/s10517-015-2825-9

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

638-40

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

158

pub_type

杂志文章
  • Inhibition of Apoptosis Stages of Human Blood Lymphocytes after Exposure to Carbon Monoxide in the Presence of Recombinant Interleukin-2.

    abstract::We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of r...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3616-2

    authors: Artyukhov VG,Tyunina OI

    更新日期:2017-01-01 00:00:00

  • Cholinergic and GABAergic innervation regulate activity of electrogenic ionic pump in earthworm somatic muscle cells.

    abstract::Carbacholine reduced, while baclofen and norepinephrine increased resting membrane potential in earthworm somatic muscle cells. In the presence of carbacholine, neither norepinephrine, nor baclofen hyperpolarized the membrane. Ouabain decreased resting potential and abolished the effects of carbacholine, norepinephrin...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0279-4

    authors: Volkov EM,Sabirova AR,Volkov ME,Zefirov AL

    更新日期:2007-08-01 00:00:00

  • Morphofuctional aspects of antitumor activity of low-intensity microwave resonance radiation in experiment.

    abstract::Effects of low-intensity microwave radiation with bioactive frequency were studied in rats with transplanted sarcoma 45. After exposure to microwave radiation in the regimen of activation therapy, the antitumor effect was observed in 50% animals (marked inhibition of tumor growth or its partial regression). Light and ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1216-0

    authors: Gudzkova TN,Zhukova GV,Garkavi LH,Sukhanova MI,Evstratova OF,Barteneva TA

    更新日期:2011-03-01 00:00:00

  • Modulating effect of interleukin-4 on free radical processes in the brain of rats during emotional stress.

    abstract::We studied the effect of anti-inflammatory cytokine IL-4 on the intensity of free radical processes in emotiogenic brain structures (hypothalamus, sensorimotor cortex, and amygdala) in rats with different prognostic emotional resistance. One-hour immobilization of animals with simultaneous electrocutaneous stimulation...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1340-x

    authors: Pertsov SS,Koplik EV,Kalinichenko LS

    更新日期:2011-08-01 00:00:00

  • Resistance of native and circulating modified low-density lipoproteins in human blood to association.

    abstract::The resistance of native and circulating modified low-density lipoproteins from human blood to spontaneous and polyethylene glycol-induced association was studied by recording light transmission fluctuations. Circulating modified low-density lipoproteins were less resistant to association than native low-density lipop...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0047-2

    authors: Suprun IV,Mel'nichenko AA,Sobenin IA,Panasenko OM,Orekhov AN

    更新日期:2004-10-01 00:00:00

  • Diagnosis of nitrosative stress by quantitative EPR-spectroscopy of epidermal cells.

    abstract::Quantitative assay of nitric oxide (NO) and iron (Fe) was carried out by the electron paramagnetic resonance (EPR) method in epidermal derivative (hair) of 45 liquidators of the Chernobyl accident, 30 employees of radiological institutions having contact with radiation, and 50 students of Vladimir State University, mo...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2042-3

    authors: Petukhov VI,Baumane LK,Reste ED,Zvagule TY,Romanova MA,Shushkevich NI,Sushkova LT,Skavronsky SV,Shchukov AN

    更新日期:2013-04-01 00:00:00

  • Endogenous progenitors as the source of cell material for ischemic damage repair in experimental myocardial infarction under conditions of changed concentration of vascular endothelial growth factor.

    abstract::We studied the effect of VEGF-A in experimental myocardial infarction on attraction of progenitor cells into the regeneration zone. The appearance of CD34(+)CD45(+) cells known as low-differentiated progenitor cells was observed in the damaged myocardial tissue in the presence of a considerable excess of VEGF-A. These...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2801-4

    authors: Shurygin MG,Shurygina IA,Dremina NN,Kanya OV

    更新日期:2015-02-01 00:00:00

  • Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

    abstract::Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decr...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3676-3

    authors: Povarov IS,Kondratenko RV,Derevyagin VI,Myasoedov NF,Skrebitsky VG

    更新日期:2017-03-01 00:00:00

  • Nrf2-Dependent Expression of Glutathione Antioxidant System Genes and Redox Status in Cells of In Vivo Drug-Resistant Murine P388 Leukemia Strains.

    abstract::We measured the content of ROS and malondialdehyde in cells of in vivo drug-resistant murine P388 leukemia strains. It was found that the strains did not differ by malondialdehyde concentration, but intracellular concentration of ROS in cells of the cyclophosphamide-resistant strain (P388/CP) was higher than in cells ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04861-2

    authors: Balakina AA,Raevskaya TA,Pavlov VS,Mumyatova VA,Goncharova SA,Terent'ev AA

    更新日期:2020-06-01 00:00:00

  • Dysregulation in neuroimmunopathology and perspectives of immunotherapy.

    abstract::Dysregulation of neuroimmune connections is a primary or secondary pathogenic factor of some CNS diseases. Autoimmune aggression is typical of multiple sclerosis, Alzheimer's disease, and epilepsy, while dysregulation characterized by enhanced production of autoantibodies to neurotransmitters and activation of cell fa...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章,评审

    doi:10.1023/a:1017964229295

    authors: Evseev VA,Davydova TV,Mikovskaya OI

    更新日期:2001-04-01 00:00:00

  • Differentiation of dissociated rat embryonic brain after allotransplantation into damaged nerve.

    abstract::Fragments of the dorsolateral wall of the anterior brain vesicle from rat embryos on embryonic day 15 were dissociated and the resultant suspension containing single cells and cell aggregates was injected into the proximal segment of crushed sciatic nerve of adult animals for evaluation of their engrafting and differe...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2296-9

    authors: Petrova ES,Isaeva EN,Korzhevskii DE

    更新日期:2013-11-01 00:00:00

  • Characteristics of human bone marrow mesenchymal stem cells isolated by immunomagnetic selection.

    abstract::Immunophenotype of human bone marrow mesenchymal stem cells was studied after several culturing passages and after cryopreservation. Immunocytochemical analysis showed that bone marrow mesenchymal stem cells acquired homogeneity during in vitro culturing, but initially contained heterogeneous populations. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0108-1

    authors: Lagar'kova MA,Lyakisheva AV,Filonenko ES,Volchkov PY,Rubtsova KV,Gerasimov YV,Chailakhyan RK,Kiselev SL

    更新日期:2006-01-01 00:00:00

  • Effect of electromagnetic radiation modulated by biostructures on the course of alloxan-induced diabetes mellitus in rats.

    abstract::Exposure of rats with experimental diabetes mellitus to wide-band electromagnetic radiation generated by He-Ne laser and modulated by the pancreas and spleen is informing and phenomenological method prolonging animal life span, normalizing blood glucose level, and promoting regeneration of the pancreas. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0049-3

    authors: Garyaev PP,Kokaya AA,Mukhina IV,Leonova-Garyaeva EA,Kokaya NG

    更新日期:2007-02-01 00:00:00

  • In vitro effects of bipathic treatment with antibodies in ultralow doses during long-term post-tetanic potentiation.

    abstract::We studied the effects of individual or combination treatment with monoclonal antibodies 5F5-B6 in ultralow doses specifically marking mossy fibers in rat hippocampus and antibodies to S100 protein during long-term post-tetanic potentiation in hippocampal slices. The possible mechanisms of changes produced by therapeu...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1024715821327

    authors: Epstein OI,Beregovoi NA,Pankova TM,Sorokina NS,Starostina MV,Shtark MB

    更新日期:2003-01-01 00:00:00

  • Transcriptional activation of cytochrome P450 1A1 with alpha-tocopherol.

    abstract::Peroral administration of alpha-tocopherol in a daily dose of 150 mg/kg for 1, 4, 8, and 12 days leads to induction of cytochromes P450 1A in male rats. Activity of CYP1A1 and CYP1A2 increased most significantly one day after alpha-tocopherol administration (by 2.6 and 2.7 times, respectively). CYP1A1 was immunohistoc...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0007-x

    authors: Sidorova YA,Grishanova AY,Lyakhovich VV

    更新日期:2004-09-01 00:00:00

  • Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.

    abstract::We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver. Under conditions of acute res...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3817-8

    authors: Fomenko EV,Bobyntsev II,Kryukov AA,Ivanov AV,Andreeva LA,Myasoedov NF

    更新日期:2017-08-01 00:00:00

  • Efficiency of trekrezan in experimental bronchopneumonia in rats.

    abstract::Trekrezan in a dose of 25 mg/kg normalized the lymphocyte immune status and produced an energy-stabilizing effect, which manifested in decreased levels of lactate, ADP, and AMP and increased content of pyruvate and ATP in blood lymphocytes and lung tissue of rats with experimental acute bronchopneumonia. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0328-4

    authors: Zarubina IV,Bolekhan AV,Shabanov PD

    更新日期:2006-08-01 00:00:00

  • Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency-dependent MPTP-induced depressive syndrome.

    abstract::The development of MPTP-induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain frontal cortex. Prolyl endopeptidase activity in the striatum also increased under these conditions. Our results indicate that proline-specific peptidases in the ta...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0416-5

    authors: Krupina NA,Zolotov NN,Bogdanova NG,Orlova IN,Khlebnikova NN,Kryzhanovskii GN

    更新日期:2006-11-01 00:00:00

  • On the mechanism of anti-ischemic effects of afobazole.

    abstract::The anti-ischemic effect of synthetic and pharmacologically tested anxiolytic afobazole (10 mg/kg intravenously) was studied on anesthetized rats with acute endocardial ischemia caused by isoproterenol infusion (20 mg/kg/min). A calcium antagonist verapamil (1 mg/kg intravenously) belonging to the group of phenyl alky...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2246-6

    authors: Seredenin SB,Tsorin IB,Vititnova MB,Stolyaruk VN,Chichkanov GG,Kryzhanovskii SA

    更新日期:2013-10-01 00:00:00

  • Morphological Changes in Mesenteric Lymph Nodes and Lymphocyte Subpopulation Composition in Experimental Ulcerative Colitis.

    abstract::Morphological changes in the mesenteric lymph nodes of male C57Bl/6 mice and subpopulation composition of lymphocytes in these nodes were studied in experimental acute and chronic ulcerative colitis induced by sodium dextran sulfate. Acute and chronic ulcerative colitis was associated with the development of reactive ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3322-5

    authors: Postovalova EA,Khochansky DN,Zolotova NA,Gao Y,Makarova OV,Dobrynina MT

    更新日期:2016-04-01 00:00:00

  • Study of polymorphic variants C190T, G191A, G857A, and 859Del of the NAT2 gene by the method of restriction fragment length polymorphism.

    abstract::New methods of restriction fragment length polymorphism analysis were developed to distinguish polymorphic variants C190T, G191A, G857A, and 859Del of the NAT2 gene located close to each other. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0309-5

    authors: Nikishina MV,Vavilin VA,Lyakhovich VV

    更新日期:2008-10-01 00:00:00

  • Mechanisms of hyperpolarizing effect of GABA on resting potential of the Lumbricus terrestris muscular wall somatic cells.

    abstract::GABA, baclofen, isoguvacine increase, and cis-4-aminocrotonic acid does not modify resting membrane potential of muscle cells. Bicuculline, phaclofen, N-ethylmaleimide, chlorpromazine, verapamil, and removal of Ca2+ from bathing solution abolished the effect of baclofen, while U73122 and D609 were ineffective in this ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0261-y

    authors: Volkov EM,Sabirova AR,Grishin SN,Zefirov AL

    更新日期:2005-02-01 00:00:00

  • Dynamics of chromosomal aberrations in male mice of various strains during aging.

    abstract::We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1017940418751

    authors: Rozenfel'd SV,Togo EF,Mikheev VS,Popovich IG,Zabezhinskii MA,Anisimov VN

    更新日期:2001-05-01 00:00:00

  • Photoprotective activity of melanin preparations from black yeast-like fungus during UV irradiation of human skin: dependence on the concentration.

    abstract::The effect of melanin solutions on the skin exposed to UV irradiation (1,050 kJ/m(2)) depended on its dose and varied from photoprotection (0.005 mg/ml) to photosensitization and phototoxicity (burn, 0.1 mg/ml). These results suggest that doses of melanin preparations should be empirically selected to achieve optimum ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1016254222805

    authors: Paramonov BA,Turkovskii II,Potokin IL,Chebotarev VY

    更新日期:2002-04-01 00:00:00

  • Dynamics of tumor growth in Brattleboro and WAG rats injected with Walker 256 carcinosarcoma cells in different doses.

    abstract::The peculiarities of Walker 256 tumor growth depending on the dose of transplanted cells were studied in rats differing by vasopressin production. Transplantation of 10(5) cells does not lead to tumor development. The dose of 7 x 10(5) cells induces progressively growing tumors in WAG rats, while in Brattleboro rats t...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0001-1

    authors: Khegay II,Popova NA,Ganilova LS,Shnyder EP,Ivanova LN

    更新日期:2008-01-01 00:00:00

  • Effect of phosphatidylcholine liposome on regeneration of surgical wound in guinea pig lung.

    abstract::Phosphatidylcholine liposomes in a dose of 25 mg/kg displayed wound-healing properties. They increased the count of alveolar macrophages, lymphocytes, and microvessels in damaged regions and, therefore, attenuated emphysematous changes in the lungs. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1017564517055

    authors: Kornilova ZK,Selishcheva AA,Perel'man MI

    更新日期:2001-02-01 00:00:00

  • Effect of low-choline diet and ethanol on electroconductivity of tissues in CBA mice.

    abstract::We studied electrophysiological parameters and morphological changes in the adrenal glands and spleen of CBA mice feeding a low-choline diet and/or ethanol-containing diet. The polarization coefficient underwent similar changes in the adrenal glands and spleen, which was associated with different contribution of imped...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0009-3

    authors: Tornuev YV,Nepomnyashchikh LM,Koldysheva EV

    更新日期:2005-11-01 00:00:00

  • Regulation of functional activity of bone marrow hemopoietic stem cells by erythroid cells in mice.

    abstract::Transplantation of erythroid and bone marrow cells to irradiated mice stimulated exogenous colony formation. Pretreatment of erythroid cells with specific rabbit antiserum to erythroblasts abolished this effect. The reverse transcriptase polymerase chain reaction revealed the presence of mRNA for interleukin-1alpha, i...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:

    authors: Sennikov SV,Inzhelevskaya TV,Eremina LV,Kozlov VA

    更新日期:2000-12-01 00:00:00

  • Correlation of intracellular Ca(2+)-activated proteinase activity and cholesterol content in white sea mussel (Mytilus edulis) membranes at different water saltiness.

    abstract::Correlation between changes in activity of intracellular Ca(2+)-activated proteinases and cholesterol content in mussels in response to changes in habitat saltiness was detected in mollusks from littoral and sublittoral White sea zones. Calpain activity in mussels decreased in low water saltiness and increased in high...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0518-5

    authors: Kyaivyaryainen EI,Nefedova ZA,Bondareva LA,Alekseeva NN,Nemova NN

    更新日期:2005-10-01 00:00:00

  • Role of MEK, PI3, p38, Tyrosine, and mTOR Kinases in Regulation of Heart Resistance to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion.

    abstract::MEK, PI3, p38, tyrosine, and mTOR kinases are not involved in the regulation of heart resistance to the arrhythmogenic action of short-term ischemia/reperfusion in non-adapted rats. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2848-2

    authors: Maslov LN,Mukhomedzyanov AV,Tsibulnikov SY,Chauski EI,Khaliulin IG,Portnichenko AG

    更新日期:2015-04-01 00:00:00