Serum levels of neurosteroids in patients with affective disorders.

Abstract:

:According modern biological hypotheses of the pathogenesis of affective disorders, hypothalamic-pituitary-adrenal axis dysfunction play a special role in the pathogenesis of this condition. Our study shows that the range of neuroprotective neurosteroids is gender- and nosology-dependent. Patients with affective disorders have reduced levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate; the most pronounced deficiency of neuroprotective neurosteroids is typical of patients with a single depressive episode. Reduced levels of neurosteroids producing an anabolic effect probably indicate depletion of adaptive capacities of the hypothalamic-pituitary-adrenal system in affective disorders.

journal_name

Bull Exp Biol Med

authors

Levchuk LA,Vyalova NM,Ivanova SA,Simutkin GG,Lebedeva EV,Bokhan NA

doi

10.1007/s10517-015-2825-9

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

638-40

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

158

pub_type

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