Changes in phenotype of monocyte-like THP-1 cells associated with transendothelial migration.

Abstract:

:The level of expression of CD11b and HLA-DR surface molecules on monocyte-like THP-1 cells increased significantly as a result of transmigration of these cells through a monolayer of endothelial cells. The expression of all studied markers (CD11b, HLA-DR, and CD-14) increased significantly after transendothelial migration in the presence of TNF-alpha and IFN-gamma. The changes in surface phenotype of THP-1 cells after transendothelial migration in the presence of TNF-alpha were more pronounced than in the presence of IFN-gamma. Transendothelial migration of THP-1 cells in the presence of IL-4 caused less pronounced changes in the surface phenotype, which did not differ from changes in transmigration without cytokines.

journal_name

Bull Exp Biol Med

authors

Starikova EA,Sokolov DI,Chernova AA,Freidlin IS

doi

10.1007/s10517-009-0350-4

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

596-8

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

146

pub_type

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