Abstract:
:The level of expression of CD11b and HLA-DR surface molecules on monocyte-like THP-1 cells increased significantly as a result of transmigration of these cells through a monolayer of endothelial cells. The expression of all studied markers (CD11b, HLA-DR, and CD-14) increased significantly after transendothelial migration in the presence of TNF-alpha and IFN-gamma. The changes in surface phenotype of THP-1 cells after transendothelial migration in the presence of TNF-alpha were more pronounced than in the presence of IFN-gamma. Transendothelial migration of THP-1 cells in the presence of IL-4 caused less pronounced changes in the surface phenotype, which did not differ from changes in transmigration without cytokines.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Starikova EA,Sokolov DI,Chernova AA,Freidlin ISdoi
10.1007/s10517-009-0350-4subject
Has Abstractpub_date
2008-11-01 00:00:00pages
596-8issue
5eissn
0007-4888issn
1573-8221journal_volume
146pub_type
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