Abstract：
:The kinetics of thrombin inhibition by irons ions was studied in the thrombin time test with normal plasma. The kinetic and concentration characteristics for recovery of thrombin activity by desferal were evaluated at various periods of thrombin incubation with iron ions. The thrombin time test showed that incubation of thrombin with iron sulfate in a final concentration of 200 microM for 25-35 min is followed by the loss of thrombin activity. Pretreatment of iron-containing incubation system with desferal was shown to decelerate the process of thrombin inactivation. The kinetic characteristics for recovery of thrombin activity by 2 mM desferal were estimated at various periods after addition of iron sulfate in the inhibitory dose. The effect of reversibility was shown to depend on the time of thrombin preincubation with iron. Incomplete recovery of thrombin activity after increasing the time of incubation with iron (more than 30 min) was probably related to oxidative modification of thrombin.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Azizova OA,Shvachko AG,Aseichev AVdoi
10.1007/s10517-010-0814-6subject
Has Abstractpub_date
2009-11-01 00:00:00pages
776-9issue
5eissn
0007-4888issn
1573-8221journal_volume
148pub_type
杂志文章abstract：:We studied the effect of ozonized physiological saline on phagocytic properties of polymorphonuclear neutrophilic leukocytes from dog blood. Intravenous infusion of the examined doses of ozonized saline stimulated phagocytosis. Repeated intravenous infusion (48 h after) of the same dose was followed by a significant d...
journal_title：Bulletin of experimental biology and medicine
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abstract：:Preparation containing ultralow doses of antibodies to stem cell factor considerably activates bone marrow myelopoiesis suppressed by cyclophosphamide. This effect of the preparation is based on stimulation of proliferation of committed hemopoietic precursors and increase in functional activity of adherent elements of...
journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-010-0764-z
更新日期：2009-09-01 00:00:00
abstract：:Consumption of low dose DDT from birth until puberty suppressed functional activity of the thyroid gland in rats and leads to destructive changes in the organ during the postpubertal period with compensatory stimulation of secretory activity of thyrocytes aimed at normalization of thyroxin production. ...
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pub_type： 杂志文章
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