Effects of histochrom and emoxypin on biophysical properties of electroexitable cells.

Abstract:

:Comparative investigation of effects of antioxidant agents histochrom and emoxypin on biophysical characteristics of isolated neurons from shell Lymnaea stagnalis under normal conditions and during oxidative stress was performed. Differently directed effects of these compounds on resting potential and transmembrane ion currents of neural cells under normal conditions were detected. Histochrom provides hyperpolarizing and emoxypin--depolarizing effect on neuronal membrane potential. Under conditions of oxidative stress both products possess antioxidant action. Obtained data allows coming closer to understanding of cellular-molecular mechanisms of protective action of compounds.

journal_name

Bull Exp Biol Med

authors

Mischenko NP,Fedoreev SA,Zapara TA,Ratushnyak AS

doi

10.1007/s10517-009-0473-7

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

196-200

issue

2

eissn

0007-4888

issn

1573-8221

journal_volume

147

pub_type

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