Abstract:
:Comparative investigation of effects of antioxidant agents histochrom and emoxypin on biophysical characteristics of isolated neurons from shell Lymnaea stagnalis under normal conditions and during oxidative stress was performed. Differently directed effects of these compounds on resting potential and transmembrane ion currents of neural cells under normal conditions were detected. Histochrom provides hyperpolarizing and emoxypin--depolarizing effect on neuronal membrane potential. Under conditions of oxidative stress both products possess antioxidant action. Obtained data allows coming closer to understanding of cellular-molecular mechanisms of protective action of compounds.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Mischenko NP,Fedoreev SA,Zapara TA,Ratushnyak ASdoi
10.1007/s10517-009-0473-7subject
Has Abstractpub_date
2009-02-01 00:00:00pages
196-200issue
2eissn
0007-4888issn
1573-8221journal_volume
147pub_type
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