Macrophage-granulocyte colony-stimulating factor and fibroblast growth factor in the blood of patients with hyperlipoproteinemia.

abstract：:Morphological changes in the thymus of female Wistar rats with experimental mammary gland carcinomas were studied. After adjuvant therapy, the area of the cortical matter and density of parenchymal cells in the thymus decreased, while areas of the medulla, connective tissue, and content of immunoblasts and macrophages...

journal_title：Bulletin of experimental biology and medicine

authors： Kazakov OV,Kabakov AV,Poveshchenko AF,Ishchenko IY,Poveshchenko OV,Strunkin DN,Raiter TV,Michurina SV,Konenkov VI

更新日期：2017-03-01 00:00:00

abstract：:We studied the neuroprotective effect of a new selective anxiolytic afobazole on rats with bilateral focal ischemic stroke in the prefrontal cortex caused by photothrombosis. Intraperitoneal injection of 5 mg/kg afobazole 1 h after surgery and over the next 8 days (daily treatment) produced a neuroprotective effect. A...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Romanova GA,Shakova FM

更新日期：2008-02-01 00:00:00

abstract：:We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensiti...

journal_title：Bulletin of experimental biology and medicine

authors： Fomicheva EE,Nemirovich-Danchenko EA,Korneva EA

更新日期：2004-06-01 00:00:00

abstract：:Experiments of 42 outbred male albino rats (160-180 g) showed an increase in the content of CD64, fibroblast growth factor, and proapoptotic proteins (p53 and p21) in the renal cortical matter on day 45 of experimental chronic Masugi nephritis. A positive correlation between CD64 and fibroblast growth factor character...

journal_title：Bulletin of experimental biology and medicine

authors： Rogovyi YE,Arkhipova LG,Dikal MV,Filipova LO,Mil' EN

更新日期：2007-10-01 00:00:00

abstract：:Digital simulation of disorders in the p53 and Mdm2 protein system, involved in repair of DNA defects and in many vital processes, including tumor formation, neurodegeneration, and aging, was carried out on the base of functional nonlinear octoparametric mathematical model. Stress situations were studied, associated w...

journal_title：Bulletin of experimental biology and medicine

authors： Voropaeva OF,Shokin YI,Nepomnyashchikh LM,Senchukova SR

更新日期：2014-08-01 00:00:00

abstract：:Myocardial remodeling in SHR rats with age-related hypertrophy was characterized by elimination of cardiomyocytes, their hypertrophy, and marked increase in the volume of the connective tissue. The count of cardiomyocytes with contracture injuries and subsegmental contractures increased, and pronounced perivascular an...

journal_title：Bulletin of experimental biology and medicine

authors： Lushnikova EL,Nepomnyashchikh LM

更新日期：2003-02-01 00:00:00

abstract：:Using rat model of experimental sarcoma M-1 we studied the efficacy of photodynamic therapy with boronated chlorine as a photosensitizer in doses of 1.25, 2.5, 5.0, and 10.0 mg/ kg body weight. Laser irradiation was performed at energy densities of 150, 300 J/cm(2) and power density of 0.25 and 0.42 W/cm(2). Treatment...

journal_title：Bulletin of experimental biology and medicine

authors： Kaplan MA,Ol'shevskaya VA,Osipchuk YS,Nikitina RG,Kalinin VN

更新日期：2014-05-01 00:00:00

abstract：:We propose a method of creation of a 3D matrix consisting of native collagen fibers and natural polysaccharide chitosan. The collagen-chitosan hydrogels maintain viability and prolipherative activity of embryonic stem cells obtained from internal cells of mouse blastocyst. The proposed system forming hydrogels in situ...

journal_title：Bulletin of experimental biology and medicine

authors： Selezneva II,Savintseva IV,Vikhlyantseva EF,Davydova GA,Gavrilyuk BK

更新日期：2006-07-01 00:00:00

abstract：:The effects of Biopin (ointment containing pine resin) used in the treatment of burns, wounds, and pyoinflammatory processes on cell composition of the wound surface (smears) and granulation tissue were studied on rats. In vitro antibacterial activity of the drug was also evaluated. At the early stage of inflammation ...

journal_title：Bulletin of experimental biology and medicine

authors： Simbirtsev AS,Konusova VG,Mchelidze GSh,Fidarov EZ,Paramonov BA,Chebotarev VY

更新日期：2002-05-01 00:00:00

abstract：:Anaferon (pediatric formulation) administered in the therapeutic-and-prophylactic regimen to mice receiving intranasally 100% infecting dose of A/California/07/2009(H1N1)v influenza virus exhibited an antiviral effect and 10-fold reduced the production of influenza virus in the lungs of infected mice on days 4, 6, and...

journal_title：Bulletin of experimental biology and medicine

authors： Shishkina LN,Skarnovich MO,Kabanov AS,Sergeev AA,Olkin SE,Tarasov SA,Belopolskaya MV,Sergeeva SA,Epstein OI,Malkova EM,Stavsky EA,Drozdov IG

更新日期：2010-10-01 00:00:00

abstract：:Antioxidant properties of recombinant peroxiredoxin-6 and chimeric protein PSH combining peroxidase and superoxide dismutase activities were studied on the model of retrograde perfusion of isolated rat heart under conditions of H2O2-induced oxidative stress. The exogenous antioxidant proteins exhibited cardioprotectiv...

journal_title：Bulletin of experimental biology and medicine

authors： Karaduleva EV,Mubarakshina EK,Sharapov MG,Volkova AE,Pimenov OY,Ravin VK,Kokoz YM,Novoselov VI

更新日期：2016-03-01 00:00:00

abstract：:Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF-/- mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantita...

journal_title：Bulletin of experimental biology and medicine

authors： Karamova AE,Semenova VG,Verbenko DA,Obraztsova OA,Vanchugova KM,Nikonorov AA,Deryabin DG,Solomka VS,Kubanov AA

更新日期：2020-10-01 00:00:00

abstract：:Burn trauma increased blood chemiluminescence, while lipopolysaccharide in a dose of 1 mg/kg potentiated this effect, activated LPO, and decreased plasma antioxidant activity. In erythrocytes, superoxide dismutase activity increased, while activity of peroxide-utilizing enzymes decreased. Myeloperoxidase content incre...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhal'chik EV,Titkova SM,Anurov MV,Ettinger AP,Korkina LG

更新日期：2006-06-01 00:00:00

abstract：:The effects of intramuscular administration of neostigmine and physostigmine on Na+,K+-ATPase activity in various cerebral subdivisions were examined in rats. In CNS and peripheral tissues, both agents rapidly and significantly reduced activity of cholinesterases by 30-50%. The development of intoxication did not chan...

journal_title：Bulletin of experimental biology and medicine

authors： Dubrovskii VN,Shalabodov AD,Belkin AV

更新日期：2018-11-01 00:00:00

abstract：:The stimulatory effect of a local focus of granulation tissue, created in the bone marrow cavity, on reparative osteogenesis after tibial bone fracture was detected in experimental rats by microscopic examination of histological sections, scanning electron microscopy, and X-ray electron probe microanalysis. ...

journal_title：Bulletin of experimental biology and medicine

authors： Ir'yanov YM,Dyuryagina OV

更新日期：2014-05-01 00:00:00

abstract：:Serum activity of tartrate-resistant acid phosphatase 5b (TRAP 5b) in patients with breast cancer and prostate cancer having bone metastases was much higher than in healthy donors and patients without skeletal injuries. TRAP 5b activity in patients with breast cancer and multiple bone metastases surpassed that in pati...

journal_title：Bulletin of experimental biology and medicine

authors： Lyubimova NV,Pashkov MV,Tyulyandin SA,Gol'dberg VE,Kushlinskii NE

更新日期：2004-07-01 00:00:00

abstract：:Study of the early embryogenesis process based on the previously suggested scheme of epithelial cambial cell work has shown that cambial (or stem) cells originate from the primary ectoderm and intensely express RhoA protein and slightly express Src kinase. This explains their stem properties and the absence of differe...

journal_title：Bulletin of experimental biology and medicine

authors： Yavisheva TM,Shcherbakov SD

更新日期：2012-05-01 00:00:00

abstract：:Activation of lysosomal proteolysis and increased coenzyme Q10 level were revealed in the liver and brain of rats with individual typological features under conditions of food deprivation. Changes in cathepsin B activity in these tissues were different in behaviorally active and passive animals. We observed indirect m...

journal_title：Bulletin of experimental biology and medicine

authors： Kirbaeva NV,Sharanova NE,Zhminchenko VM,Vasil'ev AV

更新日期：2018-07-01 00:00:00

abstract：:We studied properties of bacterial biofilms during long-term culturing. The biofilms were preserved for more than 90 days under the chosen conditions. At the same time, amounts of matrix and cells underwent periodic changes. The biomass of the biofilms decreased approximately every 7 days and then returned to the prev...

journal_title：Bulletin of experimental biology and medicine

authors： Tetz GV,Artemenko NK,Zaslavskaya NV,Tetz VV

更新日期：2013-08-01 00:00:00

abstract：:Apoptosis of blood neutrophils from healthy donors was studied under conditions of cell culturing with different concentrations of H(2)O(2), selective NO synthase inhibitor, and inductor of NO synthesis (L-arginine). In vitro incubation of neutrophilic leukocytes with 5 mM H(2)O(2) led to activation of the apoptotic p...

journal_title：Bulletin of experimental biology and medicine

authors： Stepovaya YA,Zhavoronok TV,Starikov YV,Bychkov VA,Chasovskih NY,Starikova YG,Petina GV,Novitsky VV,Ryazantseva NV

更新日期：2008-12-01 00:00:00

abstract：:Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microsc...

journal_title：Bulletin of experimental biology and medicine

authors： Khaliullin TO,Shvedova AA,Kisin ER,Zalyalov RR,Fatkhutdinova LM

更新日期：2015-03-01 00:00:00

abstract：:In the presence of Fe3+ cation, S-nitrosoglutathione (GSNO) loses the potency to inhibit catalase in the system containing hemoglobin (an NO trap) with iron chelator or -SH inhibitor (a "sulfhydric poison" Hg2+). In the absence of hemoglobin, the inhibitory potency is retained in both cases. These properties are chara...

journal_title：Bulletin of experimental biology and medicine

authors： Titov VY,Osipov AN,Ibragimova LG,Petrov VA,Dolgorukova AM

更新日期：2019-11-01 00:00:00

abstract：:The risk of essential arterial hypertension was assessed in carriers of the NOS2 gene variants (rs1800482 (-954G>C), rs3730017 (C>T)). In subjects carrying C allele (rs1800482), the risk for essential arterial hypertension developing was higher by 1.7 times (OR=1.712, 95%CI 1.07-2.74), while the presence of T-allele (...

journal_title：Bulletin of experimental biology and medicine

authors： Topchieva LV,Balan OV,Korneeva VA,Malysheva IE

更新日期：2019-11-01 00:00:00

abstract：:Initiation of apoptosis by chemotherapeutic drugs is one of the most effective approaches to the treatment of cancers. Caspases, the main enzymes of apoptosis, undergo activation to initiate cell death. Activation of initiator caspases requires their binding to special protein complexes. For elucidation of the mechani...

journal_title：Bulletin of experimental biology and medicine

authors： Zamaraev AV,Egorshina AY,Lavrik IN,Zhivotovsky BD,Kopeina GS

更新日期：2019-11-01 00:00:00

abstract：:We developed an optimal protocol for preparing and culturing of olfactory ensheathing cells from human olfactory mucosa. Using this protocol, we obtained a culture enriched with human olfactory ensheathing cells. Immunofluorescence analysis by simultaneous expression of GFAP and p75NTR markers showed that the content ...

journal_title：Bulletin of experimental biology and medicine

authors： Voronova АD,Stepanova OV,Valikhov MP,Chadin AV,Dvornikov АS,Reshetov IV,Chekhonin VP

更新日期：2018-03-01 00:00:00

abstract：:We studied a combined effect of subcomponents of vitamin B complex on the growth, development, and death of human embryonic brain-derived cells (E90) cultured using a modified method of Matson. Cell death was detected by trypan blue staining. According to our results, vitamin B-complex in low-doses promote the develop...

journal_title：Bulletin of experimental biology and medicine

authors： Danielyan KE,Abramyan RA,Galoyan AA,Kevorkian GA

更新日期：2011-09-01 00:00:00

abstract：:Ready dosage form (eye drops) prepared on the basis of recombinant alpha2-IFN exhibits high activity towards herpes simplex type 1 virus in vitro. Systematic study of the antiherpesvirus effect of this drug in combination with modified nucleosides showed an inhibitory effect of the synergic type. Combination of IFN pr...

journal_title：Bulletin of experimental biology and medicine

authors： Vyzhlova EN,Andronova VL,Galegov GA,Malinovskaya VV

更新日期：2006-06-01 00:00:00

abstract：:The efficiency of drug therapy should be evaluated by not only its directed action on specific organ or target parameter, but also its effects on general regulatory and adaptive status. ...

journal_title：Bulletin of experimental biology and medicine

authors： Pokrovskii VM,Kompaniets OG

更新日期：2008-06-01 00:00:00

abstract：:The cell composition of leukocyte infiltrates in the endometrium, myometrium, and vaginal walls was studied in Wistar rats with modeled chronic endomyometritis after administration of IFNγ (0.1 μg/100 g body weight) in different daily regimens (10.00 or 20.00). Morning injections of this cytokine ameliorated inflammat...

journal_title：Bulletin of experimental biology and medicine

authors： Dergacheva TI,Shurlygina AV,Abdalova AM,Klimontov VV,Trufakin VA,Letyagin AY

更新日期：2020-08-01 00:00:00

abstract：:The rats were divided into groups demonstrating extremely high and low stress reactivity depending on the results of testing for the nociceptive threshold and thermolability in response to bacterial lipopolysaccharide administration. Specific structural features of the nucleus and mitochondria were revealed in neurons...

journal_title：Bulletin of experimental biology and medicine

authors： Potanin MB,Tumanov VP,Pisarev VB

更新日期：2007-11-01 00:00:00