Evaluation of fibrogenic potential of industrial multi-walled carbon nanotubes in acute aspiration experiment.

Abstract:

:Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers.

journal_name

Bull Exp Biol Med

authors

Khaliullin TO,Shvedova AA,Kisin ER,Zalyalov RR,Fatkhutdinova LM

doi

10.1007/s10517-015-2835-7

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

684-7

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

158

pub_type

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