Abstract：
:In the presence of Fe3+ cation, S-nitrosoglutathione (GSNO) loses the potency to inhibit catalase in the system containing hemoglobin (an NO trap) with iron chelator or -SH inhibitor (a "sulfhydric poison" Hg2+). In the absence of hemoglobin, the inhibitory potency is retained in both cases. These properties are characteristic of dinitrosyl-iron complexes containing ferrous iron and thiols (DNIC/RSH). Since the potency to inhibit catalase results from the presence of -NO group, its loss in the presence of hemoglobin relates probably to transfer of this group to hemoglobin. The nitrosothiols are relatively stable compounds, so their ability to release NO under the action of iron chelators, which is characteristic of DNIC/RSH, can have important physiological implications, because the role of such chelators can be played by some endogenous agents as well. Thus, release of NO from the donor compounds can be controlled and regulated. Probably, the agents such as nitrosothiol+Fe3+ are the major constituents in the pool of nitroso compounds.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Titov VY,Osipov AN,Ibragimova LG,Petrov VA,Dolgorukova AMdoi
10.1007/s10517-019-04641-7subject
Has Abstractpub_date
2019-11-01 00:00:00pages
41-44issue
1eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04641-7journal_volume
168pub_type
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