Mechanisms of Erythropoietin-Stimulating Action of Anti-Erythropoietin Release-Active Antibodies in Complex Treatment of Experimental Anemia during Gestation.

Abstract:

:We studied the mechanisms of erythropoiesis stimulation and effectiveness of Poetam, a preparation containing release-active anti-erythropoietin antibodies as a supplement treatment for experimental iron deficiency anemia during gestation. The results confirmed potency of combined therapy to stimulate erythropoiesis, which was more efficacious in comparison with monotherapy as assessed by the count of erythrokaryocytes and erythroid progenitors in the hematopoietic tissue as well as by the content of erythrocytes and hemoglobin in the peripheral blood. Activation of erythropoiesis is related to the modulatory effect of Poetam on proliferative activity and differentiation of erythroid precursors, which in most aspects results from stimulatory action of Poetam on secretion of the hematopoietically active factors by adherent elements of the hematopoietic microenvironment.

journal_name

Bull Exp Biol Med

authors

Burmina YV,Udut EV,Zhdanov VV,Sotnikova LS,Miroshnichenko LA,Simanina EV,Polyakova TY,Zyuz'kov GN,Chaikovskii AV,Stavrova LA,Epshtein OI,Dygai AM

doi

10.1007/s10517-016-3298-1

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

737-41

issue

6

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-016-3298-1

journal_volume

160

pub_type

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