Abstract：
:Lipemia modeled by injections of Triton WR-1339 (500 mg/kg) and poloxamer 407 (500 mg/kg) to mice were compared. LP fraction and subfraction compositions were compared by small-angle X-ray scattering on a diffractometer. Both compounds in the same dose caused a sharp increase in serum concentrations of total cholesterol (CH) and triglycerides (TG), the increases in response to poloxamer 407 being more pronounced. The differences in the models consisted in the levels of atherogenic fractions: CH-VLDL (subfractions CH-VLDL1-2) and CH-LDL, which were higher under the effect of poloxamer 407. Similar increases were observed for atherogenic fractions: TG-VLDL (subfractions TG-VLDL1-2) and TG-LDL (subfractions TG-LDL1-3). A specific feature of the model induced by poloxamer 407 was elevation of the concentrations of antiatherogenic CH-HDL and TG-HDL (subfractions CH-HDL2 and TG-HDL2). Both models exhibited high similarity, but changes in atherogenic fractions were more pronounced under the effect of poloxamer 407.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Loginova VM,Tuzikov FV,Tuzikova NA,Korolenko TAdoi
10.1007/s10517-013-2133-1subject
Has Abstractpub_date
2013-06-01 00:00:00pages
284-7issue
2eissn
0007-4888issn
1573-8221journal_volume
155pub_type
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