Abstract:
:We studied changes in protein composition and their effects on convulsive activity in drug-induced and electrical kindling. Injection of protein fraction of brain extract from animals subjected to metronidazole-induced kindling to intact recipients reduced their sensitivity to the convulsant (i. e. increased the dose of metronidazole inducing clonic convulsions and lethal seizures). Incorporation of labeled amino acids in proteins in different brain structures after appearance of stable afterdischarges in the zone of synaptic stimulation significantly decrease compared to the control. Label incorporation decreased also in the frontal and occipital cortex. Kindling-associated changes in the protein spectrum were studied by electrophoresis.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Karpova MN,Karganov MY,Klishina NY,Khlebnikova NN,Kryzhanovskii GNdoi
10.1023/a:1020265305153subject
Has Abstractpub_date
2002-06-01 00:00:00pages
544-7issue
6eissn
0007-4888issn
1573-8221journal_volume
133pub_type
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