Effects of antibodies to glutamate on focal penicillin-induced epileptic activity.

Abstract:

:The effects of intranasal pretreatment with antibodies against glutamate on focal penicillin-induced epileptic activity were studied by recording electrocorticogram in non-anesthetized freely moving male Wistar rats. Anticonvulsant effects of intranasal administration of anti-glutamate antibodies (300 μg/kg) 1 h before application of penicillin (30,000 U/ml) on the sensorimotor cortex was demonstrated: the latency of ictal discharges increased and their frequency decreased.

journal_name

Bull Exp Biol Med

authors

Kuznetsova LV,Karpova MN,Vetrile LA,Klishina NY

doi

10.1007/s10517-013-2206-1

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

609-11

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

155

pub_type

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