Abstract:
:The effects of intranasal pretreatment with antibodies against glutamate on focal penicillin-induced epileptic activity were studied by recording electrocorticogram in non-anesthetized freely moving male Wistar rats. Anticonvulsant effects of intranasal administration of anti-glutamate antibodies (300 μg/kg) 1 h before application of penicillin (30,000 U/ml) on the sensorimotor cortex was demonstrated: the latency of ictal discharges increased and their frequency decreased.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kuznetsova LV,Karpova MN,Vetrile LA,Klishina NYdoi
10.1007/s10517-013-2206-1subject
Has Abstractpub_date
2013-09-01 00:00:00pages
609-11issue
5eissn
0007-4888issn
1573-8221journal_volume
155pub_type
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