Preventive and therapeutic effect of complex antioxidant preparation in rats with burn trauma.

abstract：:We studied the formation and cytophysiological characteristics of polynuclear macrophages in primary cultures of peritoneal cells from C57Bl/6 mice. Production of reactive oxygen species and phagocytic activity in polynuclear macrophages were higher than in mononuclear macrophages. The formation of polynuclear macroph...

journal_title：Bulletin of experimental biology and medicine

authors： Arkhipov SA,Shkurupiy VA,Ijine DA,Ignatovich NV,Akhromenko ES,Arkhipova VV

更新日期：2008-12-01 00:00:00

abstract：:The effect of low dose dichlorodiphenyltrichloroethane (DDT), omnipresent ecotoxicant and endocrine disruptor, on the functioning of the endocrine system is an urgent problem. We studied the effect of low dose DDT on thyroid status in rats. Rats receiving DDT in a dose of 1.890±0.086 μg/kg for 6 weeks showed increased...

journal_title：Bulletin of experimental biology and medicine

authors： Yaglova NV,Yaglov VV

更新日期：2014-04-01 00:00:00

abstract：:We studied the effect of succinic acid on the process of glucuronidation of 2-ethyl-6-methyl-3-hydroxypyridine after peroral and intraperitoneal administration in the form of succinate or a base. Since the basic form of 2-ethyl-6-methyl-3-hydroxypyridine is insoluble in water, it was administered in 5% Tween-80. It wa...

journal_title：Bulletin of experimental biology and medicine

authors： Baranov PA,Kravtsova OU,Sariev AK,Sherdev VP

更新日期：2008-07-01 00:00:00

abstract：:We studied the effect of VEGF-A in experimental myocardial infarction on attraction of progenitor cells into the regeneration zone. The appearance of CD34(+)CD45(+) cells known as low-differentiated progenitor cells was observed in the damaged myocardial tissue in the presence of a considerable excess of VEGF-A. These...

journal_title：Bulletin of experimental biology and medicine

authors： Shurygin MG,Shurygina IA,Dremina NN,Kanya OV

更新日期：2015-02-01 00:00:00

abstract：:We studied reflection of artificially induced and amplified food motivation in impulse activity of the masticatory muscles during electrostimulation of "hunger center" of the lateral hypothalamus in the absence and presence of food. The threshold stimulation of the lateral hypothalamus in hungry and satiated animals i...

journal_title：Bulletin of experimental biology and medicine

authors： Ignatova JP,Kromin AA

更新日期：2012-04-01 00:00:00

abstract：:Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by i...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Lin'kova NS,Polyakova VO,Kvetnoy IM,Benberin VV,D'yakonov MM,Titkov YS

更新日期：2012-08-01 00:00:00

abstract：:We studied the effects of phenazepam (0.075 mg/kg) after pretreatment (5 minutes before) with naloxone (10 mg/kg) on open-field behavior of C57Bl/6 and BALB/c mice. In ex vivo experiments, we studied the effects of naloxone (1 and 10 mg/kg) on receptor binding of [(3)H]-flunitrazepam by membranes of brain fraction (P1...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Nadorova AV,Kolik LG,Yarkova MA

更新日期：2013-07-01 00:00:00

abstract：:Alloxan-induced diabetes mellitus in rats was characterized by persistent increase in blood levels of corticosterone, while chronic granulomatous inflammation induced by silicon dioxide and its combination with alloxan-induced diabetes mellitus were associated with transient increase in blood corticosterone level foll...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznetsova NV,Palchikova NA,Selyatitskaya VG,Shkurupiy VA

更新日期：2010-11-01 00:00:00

abstract：:We studied the effect of turmeric extract in the composition of rectal suppositories on the level of LPO products and oxidative modification of proteins in the colon mucosa of Wistar rats with experimental Crohn's disease modeled by rectal administration of trinitrobenzenesulfonic acid. The suppositories containing tu...

journal_title：Bulletin of experimental biology and medicine

authors： Osikov MV,Simonyan EV,Bakeeva AE,Ogneeva OI

更新日期：2020-07-01 00:00:00

abstract：:The effects of a new thietanylbenzimidazole derivative (K-134) on estrous cycles, conception processes, and sexual behavior of female rats were studied. Two-week oral treatment with K-134 in doses of 5 and 50 mg/kg shortened the estrus phase and prolonged proestrus. Changes in sexual behavior were presented by activat...

journal_title：Bulletin of experimental biology and medicine

authors： Kuzubova EA,Bugaeva LI,Sergeeva SA,Petrov VI,Kataev VA,Kharlamov IV,Mal'tsev MV

更新日期：2015-09-01 00:00:00

abstract：:Plasma concentration of immune complexes and antibodies to serotonin and dopamine were higher in patients with Alzheimer's disease compared to mentally healthy volunteers of the same age. Plasma concentrations of antibodies to serotonin and dopamine decreased with the increase in the duration of this disease. ...

journal_title：Bulletin of experimental biology and medicine

authors： Davydova TV,Mikovskaya OI,Fomina VG,Voskresenskaya NI,Doronina OA

更新日期：2002-07-01 00:00:00

abstract：:Comparative identification of cerebral regions activated in men and women during perception of indefinite images was carried out by fMRT and psychological testing. Nine men and nine women aged 20-26 years took part in the study. The volunteers examined simple geometric figures, slightly structurized images (tables fro...

journal_title：Bulletin of experimental biology and medicine

authors： Fyodorov AA,Pervushina ON,Bliznyuk MV,Khoroshilov BM,Melnikov ME,Mazhirina KG,Stark MB,Savelov AA,Petrovsky ED,Kozlova LI

更新日期：2016-07-01 00:00:00

abstract：:The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intrap...

journal_title：Bulletin of experimental biology and medicine

authors： Kolik LG,Nadorova AV,Seredenin SB

更新日期：2016-11-01 00:00:00

abstract：:We studied expression of malignancy markers galectin-3, cytokeratin-19, HBME-1, fibronectin, and cyclin D1 in cells of benign (n=51), malignant (n=87), and borderline (n=53) tumors. The results indicate that 3.9% benign and 41.5% borderline tumors express malignancy markers (specificity 98-100%). Follow up over 1-10 y...

journal_title：Bulletin of experimental biology and medicine

authors： Abrosimov AY,Dvinskikh NY,Sidorin AV

更新日期：2016-03-01 00:00:00

abstract：:The cytotoxic effects of human blood serum were studied under normal and pathological conditions. The contribution of the complement system to the realization of this effect was demonstrated. Significant differences in the serum capacity to kill foreign cells were detected for healthy subjects and asthmatics. Bovine s...

journal_title：Bulletin of experimental biology and medicine

authors： Arkhipova EN,Cherepov AB,Medvedeva YS,Alchinova IB,Karganov MY

更新日期：2012-09-01 00:00:00

abstract：:Agonists of glutamate ionotropic (NMDA) and metabotropic receptors (mGluRI and mGluRIII) had the regulatory effect on ADP-ribosyl cyclase/CD38 activity in cerebellar granular cells of newborn rats. Perinatal hypoxic-ischemic brain injury was followed by dysregulation of this mechanism. ...

journal_title：Bulletin of experimental biology and medicine

authors： Salmina AB,Okuneva OS,Mikhutkina SV,Malinovskaya NA,Morgun AV,Zykova LD,Yudin GV,Laletin DV,Fursov MA,Frolova OV,Tagaeva GA,Bolshakova EV

更新日期：2011-03-01 00:00:00

abstract：:Conditions of human BM and umbilical cord blood MSC in vitro differentiation in the hepatogenic direction were studied. Changes in cell morphology, phenotype, acquisition of the capacity to produce albumin and accumulate glycogen, express cytokeratin, alkaline phosphatase, and albumin mRNA indicated that BM and umbili...

journal_title：Bulletin of experimental biology and medicine

authors： Kosmacheva SM,Seviaryn IN,Goncharova NV,Petyovka NV,Potapnev MP

更新日期：2011-05-01 00:00:00

abstract：:Spontaneous and stimulated reaction of lymphocyte proliferation and blood levels of CD25- and CD120-expressing lymphocytes were studied in patients with autoimmune thyroiditis and diffuse toxic goiter. Activation of CD25- and CD120-presenting function of blood lymphocytes was revealed. The findings indicate that the c...

journal_title：Bulletin of experimental biology and medicine

authors： Urazova OI,Kravets EB,Nedosekova YV,Rogaleva AV,Kuznecova VN,Rumpel OA

更新日期：2008-09-01 00:00:00

abstract：:The levels of himantane and its metabolites in daily urine and feces of rats were measured after intraperitoneal and oral dose of 25 mg/kg. The injected dose of the initial substance and 1.3% its metabolites were eliminated with excrements within 24 h after administration via both routes 0.23%. ...

journal_title：Bulletin of experimental biology and medicine

authors： Litvin EA,Bastrygin DV,Kolyvanov GB,Alekseyev KV,Zherdev VP

更新日期：2012-08-01 00:00:00

abstract：:We developed wound coating based on natural biopolymer chitosan with additional components (ceruloplasmin, L-asparaginic acid, and glycerol). Experiments on albino male rats demonstrated its regeneratory, antioxidant, and antibacterial effects on wounds involving all layers of the skin. Due to chemical composition and...

journal_title：Bulletin of experimental biology and medicine

authors： Gladkova EV,Babushkina IV,Norkin IA,Mamonova IA,Puchin'yan DM,Konyuchenko EA

更新日期：2016-03-01 00:00:00

abstract：:We studied the effect of transfection of PC-3 prostate cancer cells with a plasmid encoding shRNA complimentary to a fragment of integrin β4 (ITGB4). The results attest to considerable changes in the transcriptome of transfected cells. For instance, compensatory changes in the expression of integrin family genes were ...

journal_title：Bulletin of experimental biology and medicine

authors： Knyazev EN,Nyushko KM,Alekseev BY,Samatov TR,Shkurnikov MY

更新日期：2015-08-01 00:00:00

abstract：:The effects of opioids (morphine and fentanyl) on the function of mechanoreceptive respiration regulatory loop were demonstrated. In most opioid-treated rats (74% cases) vagotomy was followed by apneustic respiration with inspiration pause. Excess of opioids in rat CNS produced minor disturbances in the respiration rh...

journal_title：Bulletin of experimental biology and medicine

authors： Tarakanov IA,Tikhomirova LN,Safonov VA

更新日期：2005-04-01 00:00:00

abstract：:The effect of melanin solutions on the skin exposed to UV irradiation (1,050 kJ/m(2)) depended on its dose and varied from photoprotection (0.005 mg/ml) to photosensitization and phototoxicity (burn, 0.1 mg/ml). These results suggest that doses of melanin preparations should be empirically selected to achieve optimum ...

journal_title：Bulletin of experimental biology and medicine

authors： Paramonov BA,Turkovskii II,Potokin IL,Chebotarev VY

更新日期：2002-04-01 00:00:00

abstract：:Apoptosis markers (p53, PUMA, p21, and Mdm2) were studied in patients with rheumatoid arthritis at the early and late stages of disease on bone marrow smears and frozen sections of the articular synovial membrane. The target molecules were found in all patients. The early stage was characterized by maximum expression ...

journal_title：Bulletin of experimental biology and medicine

authors： Doroshevskaya AY,Kondratovskii PM,Dubikov AI,Eliseikina MG

更新日期：2014-01-01 00:00:00

abstract：:We studied brown adipose tissue isolated from mice receiving 20% ethanol as a single source of fluid. In vitro O2 utilization by brown adipose tissue decreased after one month of forced alcohol intake, but surpassed the control after 3 months of ethanol drinking. The absolute and relative weight of brown adipose tissu...

journal_title：Bulletin of experimental biology and medicine

authors： Elsukova EI,Medvedev LN,Kudryavtseva NA

更新日期：2001-12-01 00:00:00

abstract：:Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for prolifera...

journal_title：Bulletin of experimental biology and medicine

authors： Romanko YS,Tsyb AF,Kaplan MA,Popuchiev VV

更新日期：2004-12-01 00:00:00

abstract：:Biopsy specimens from large bronchi of patients with central and peripheral pulmonary cancer were studied. Central cancer was associated with hyperplasia and dysplasia of the epithelium, hyperplasia of glandular compartment, and pronounced immunocompetent cell response. Peripheral cancer was characterized by predomina...

journal_title：Bulletin of experimental biology and medicine

authors： Nepomnyashchikh GI,Levitskii VA,Dolgovykh AK,Naumova LA

更新日期：2002-08-01 00:00:00

abstract：:A test system developed by the authors was used to measure serum concentrations of soluble Fas in patients with malignant and benign tumors of different location and morphology. Relationships between soluble Fas levels and the main clinical and morphological characteristics of cancer were evaluated. It is proven that ...

journal_title：Bulletin of experimental biology and medicine

authors： Abbasova SG,Vysotskii MM,Ovchinnikova LK,Obusheva MN,Digaeva MA,Britvin TA,Bahoeva KA,Karabekova ZK,Kazantzeva IA,Mamedov UR,Manuchin IB,Davidov MI

更新日期：2009-10-01 00:00:00

abstract：:Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank dem...

journal_title：Bulletin of experimental biology and medicine

authors： Rogozinskaya EY,Lyapina MG

更新日期：2017-12-01 00:00:00

abstract：:The cell composition of leukocyte infiltrates in the endometrium, myometrium, and vaginal walls was studied in Wistar rats with modeled chronic endomyometritis after administration of IFNγ (0.1 μg/100 g body weight) in different daily regimens (10.00 or 20.00). Morning injections of this cytokine ameliorated inflammat...

journal_title：Bulletin of experimental biology and medicine

authors： Dergacheva TI,Shurlygina AV,Abdalova AM,Klimontov VV,Trufakin VA,Letyagin AY

更新日期：2020-08-01 00:00:00