Abstract:
:Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for proliferation and biosynthesis.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Romanko YS,Tsyb AF,Kaplan MA,Popuchiev VVdoi
10.1007/s10517-005-0133-5subject
Has Abstractpub_date
2004-12-01 00:00:00pages
584-9issue
6eissn
0007-4888issn
1573-8221journal_volume
138pub_type
杂志文章abstract::Penetration of titanium dioxide nanoparticles into enterocytes after their administration into isolated loop of rat small intestine was shown in vivo by transmission electron microscopy. Using electron diffraction, titanium dioxide nanoparticles were identified in the apical regions of the cells under plasma membranes...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-012-1928-9
更新日期:2012-12-01 00:00:00
abstract::We studied the influence of high-fat diet on the development of metabolic syndrome in rats of hypertensive ISIAH strain and normotensive WAG strain. In contrast to ISIAH rats, high-fat diet in WAG rats led visceral obesity, glucose tolerance, and dyslipidemia. DNA-binding activity of the peroxisome proliferator-activa...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2417-0
更新日期:2014-03-01 00:00:00
abstract::We studied morphological changes in rat abdominal aorta and vena cava inferior induced by endovascular microwave destruction. This treatment induced thrombosis and necrosis of the vascular walls, but fibrous framework was not completely destroyed. Then we observed irreversible changes in vessels: obliteration, atrophy...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1020633427502
更新日期:2002-07-01 00:00:00
abstract::We studied the effect of anti-inflammatory cytokine IL-4 (5 μg/kg intraperitoneally) on peripheral blood leukocytes in Wistar rats with various behavioral characteristics during acute emotional stress (1-h immobilization with simultaneous subthreshold electrocutaneous stimulation). IL-4 reduced the differences in bloo...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-015-2814-z
更新日期:2015-03-01 00:00:00
abstract::Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD-H-2 by succinic semialdeyde a...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/BF00799318
更新日期:1975-01-01 00:00:00
abstract::Antibacterial activity of powdered preparations based on copper and silver nanoparticles was compared with activity of the reference preparation Baneocin on the model of local staphylococcal infection in white rats. The developed preparations exhibited pronounced antibacterial activity against methicillin-resistant S....
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-019-04622-w
更新日期:2019-10-01 00:00:00
abstract::Sulfamide-resistant (SulR) natural strains of enterobacteria (11.9% of a total of 797 cultures, isolated with enteric microflora of honeybee gut, bee-fermented pollen, and plant issues) were tested for class 1 antibiotic resistance integrons (MRI). Only 5.3% of SulR strains were MRI-positive. Mutability of weak (wild ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-011-1397-6
更新日期:2011-09-01 00:00:00
abstract::Intraleukocytic microbicidal activity of blood neutrophilic granulocytes in cows increased with increasing the term of pregnancy, decreased over the first 2 days after labor, and increased again in the follow-up period. Activity of microbicidal systems markedly decreased after labor, especially in the winter-spring pe...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/b:bebm.0000008968.87917.46
更新日期:2003-09-01 00:00:00
abstract::Oxidative modification of fibrinogen in acute myocardial infarction increased 1.3-fold compared to that in CHD and 1.5-fold surpassed that in the control without CHD. Elevated content of oxidized fibrinogen correlated with increased levels of LPO products, von Willebrand factor, and fibrin degradation products, with a...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-008-0104-8
更新日期:2008-04-01 00:00:00
abstract::Morphological and proliferative characteristics of cultured Vero and MDCK cells were compared after growth in nutrient media of the basis of enzymatic hydrolysates of rice flour proteins and soybean flour proteins or control media (DMEM and Axcevir-MDCK). These media had a strong stimulatory effect on the growth of cu...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-009-0536-9
更新日期:2009-04-01 00:00:00
abstract::The time course of drug adsorption and desorption, exposure of soft contact lenses in a drug solution needed for maximum saturation, and the duration of lens wearing during which the drug was transported from the lens and exhibited its therapeutic activity were studied. The possibility of using computer simulation for...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-013-2332-9
更新日期:2013-12-01 00:00:00
abstract::We studied the effect of adrenal cortex hormone dehydroepiandrosterone sulfate on maturation and functional activity of interferon-alpha-induced dendritic cells. Dehydroepiandrosterone sulfate stimulated differentiation and maturation of interferon-alpha-induced dendritic cell, which manifested in a decrease in the nu...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-009-0619-7
更新日期:2009-07-01 00:00:00
abstract::We studied the effects of chronic administration of granulocyte colony-stimulating factor in nonmobilizing doses to mice. Over 18 months of the study, 55% animals of the treatment group died of unknown cause, blood diseases and tumors were found in 20% mice, and in 5% animals pathological changes were absent. Control ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-008-0166-7
更新日期:2008-05-01 00:00:00
abstract::The development of dissociated cells from rat embryonic spinal ganglion after transplantation to damaged nerve of adult animals was studied using immunohistochemical differentiation markers of neural and glial cells. The cell suspension obtained after dissociation of rat embryonic spinal ganglia (embryonic day 15) was...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2633-7
更新日期:2014-09-01 00:00:00
abstract::Afala (ultralow-dose antibodies to prostate-specific antigen) injected for 60 days to rats with hormone-induced prostatitis caused by sulpiride prevented the development of prostatic hyperplasia and reduced the severity of histological changes. The effect of Afala was superior to that of the reference drug (Serenoa re...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-007-0409-z
更新日期:2007-11-01 00:00:00
abstract::We compared the efficiency of different stereoisomers of organic magnesium salts (Mg DL-, Mg D-, and Mg L-aspartate and Mg L- and Mg DL-glutamate) after oral administration under conditions of furosemide-induced magnesium deficiency. The time to complete compensation of erythrocyte magnesium level was 5 days for Mg L-...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-011-1323-y
更新日期:2011-07-01 00:00:00
abstract::An important role in the development of the immune response is played by macrophages that acquire either anti-inflammatory M1 or anti-inflammatory M2 phenotype depending on their microenvironment. The possibility of targeted reprogramming of the initial M2 macrophage phenotype towards M1 phenotype and vice versa using...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-012-1572-4
更新日期:2012-02-01 00:00:00
abstract::Castration had no effect on baseline BP and vascular sensitivity to acetylcholine and deficiency of nitric oxide and prostacyclin in normotensive specimens. Castration of hypertensive specimens decreased BP and potentiated the hypotensive effects of acetylcholine, but did not modulate vascular sensitivity to the block...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-012-1673-0
更新日期:2012-06-01 00:00:00
abstract::The study examined maturation of preovulatory germinal vesicles oocytes (GV oocytes) induced by gonadotropic hormone PMSG in the inbred C57Bl/6J mice (viewed as a gold standard for diverse biomedical studies) as well as in the first generation hybrid C57Bl/6J×СВА/lac and СВА/lac×C57Bl/6J mice at various ages. The most...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-019-04603-z
更新日期:2019-09-01 00:00:00
abstract::The number of CD3(+)CD56-HLA-G(+) cells in the peripheral blood of breast cancer patients was shown to increase by 2 times. Our results and published data suggest that the increase in the relative content of CD3(+)CD56-HLA-G(+) cells in the circulating blood in breast cancer contributes to tumor development due to sup...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-015-3038-y
更新日期:2015-09-01 00:00:00
abstract::Immunocytochemical study has shown that Ki-67 antigen is detected in adenomyosis in both endometrial and myometrial cell populations (in the eutopic and ectopic endometrial glandular epithelium, stromal cells, smooth muscle cells, and vascular endotheliocytes of the endometrium and myometrium), the label index differi...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-013-2190-5
更新日期:2013-08-01 00:00:00
abstract::Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by i...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-012-1766-9
更新日期:2012-08-01 00:00:00
abstract::We studied properties of bacterial biofilms during long-term culturing. The biofilms were preserved for more than 90 days under the chosen conditions. At the same time, amounts of matrix and cells underwent periodic changes. The biomass of the biofilms decreased approximately every 7 days and then returned to the prev...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-013-2180-7
更新日期:2013-08-01 00:00:00
abstract::The animals were adapted to intermittent hypoxic hypoxia in a flow pressure chamber for 3 days. Each one-day training session consisted of 4 elevations to an altitude of 6000 m for 20 min (15 m/sec, 20-min intervals between assents). Trekrezan (25 mg/kg intraperitoneally) was injected immediately after the end of dail...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-008-0010-0
更新日期:2008-01-01 00:00:00
abstract::Coagulation and optical (based on chromogenic substrate) methods were employed to examine antithrombin activity of erythrocytes and erythrocyte-derived microvesicles isolated days 7, 14, 21, and 28 on erythrocyte storage. The erythrocyte-derived microvesicles decelerated fibrin clot formation from fibrinogen in the pr...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-017-3696-z
更新日期:2017-04-01 00:00:00
abstract::We studied the effect of glyprolines Pro-Gly-Pro (PGP) and Arg-Gly-Pro (RGP) on the primary culture of pulmonary fibroblasts from newborn albino rats under normal conditions and during oxidative stress. Under physiological conditions, the peptides had no effect on parameters of cell division. Hydrogen peroxide induced...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-016-3372-8
更新日期:2016-05-01 00:00:00
abstract::Reversible cerebral ischemia of medium severity was reproduced in male Wistar rats by bilateral occlusion of the common carotid arteries. Solid-phase structures (anisomorphons) were obtained by marginal dehydration of the serum. Small focal isotropic defects in the serum anisomorphon texture were found in 100% cases d...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-018-3991-3
更新日期:2018-01-01 00:00:00
abstract::Treatment with a combination of artrofoon and anaferon significantly reduced clinical and laboratory parameters of rheumatoid inflammation and significantly decreased the content of antiinflammatory cytokines in the blood. These findings attest to antiinflammatory and immunomodulating effects of these preparations. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10517-010-0744-3
更新日期:2009-09-01 00:00:00
abstract::Adhesion activity of L. acidophilus NK1, L. fermentum 90 TS4, and C. albicans 506 B on female vaginal epithelium was studied. Adhesion of various lactobacillus species was hormone-dependent. Adhesion of C. albicans 506 B was not associated with estrogen level. The effects of synthetic drugs and phytopreparations used ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-012-1714-8
更新日期:2012-07-01 00:00:00
abstract::Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2657-z
更新日期:2014-10-01 00:00:00