Effect of interleukin-4 on peripheral blood leukocytes in rats with various behavioral characteristics during acute stress.


:We studied the effect of anti-inflammatory cytokine IL-4 (5 μg/kg intraperitoneally) on peripheral blood leukocytes in Wistar rats with various behavioral characteristics during acute emotional stress (1-h immobilization with simultaneous subthreshold electrocutaneous stimulation). IL-4 reduced the differences in blood leukocyte count in rats with various behavioral characteristics, which was related to a significant decrease in this parameter in active animals. IL-4 injection to active animals was accompanied by changes in the leukogram (development of neutrophilia, monocytopenia, and lymphopenia) and had a modulatory effect on leukocyte indexes of cell reactivity. Blood leukocyte count in cytokine-treated animals did not change after stress exposure. IL-4 prevented shifts in leukocyte indexes of cell reactivity, which was found after acute stress exposure. Our results expand current notions on the specific involvement of endogenous immunomodulatory compounds in the realization of adaptive and compensatory processes in mammals during negative emotiogenic exposures.


Bull Exp Biol Med


Pertsov SS,Koplik EV,Kalinichenko LS




Has Abstract


2015-03-01 00:00:00












  • Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging.

    abstract::Morphometric analysis of structural and functional changes in the human mesenteric lymph nodes during aging revealed the development of fibrous connective tissue, fragmentation of the lymphoid parenchyma, the absence of follicles with germinal centers, and a decrease in the level of lymphocyte proliferation, which was...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Erofeeva LM,Mnikhovich MV

    更新日期:2020-03-01 00:00:00

  • Effect of combination of anticytokine preparations anaferon and artrofoon on immune inflammation in rheumatoid arthritis.

    abstract::Treatment with a combination of artrofoon and anaferon significantly reduced clinical and laboratory parameters of rheumatoid inflammation and significantly decreased the content of antiinflammatory cytokines in the blood. These findings attest to antiinflammatory and immunomodulating effects of these preparations. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章,随机对照试验


    authors: Petrov VI,Babaeva AR,Solodenkova KS,Cherevkova EV,Zabolotneva YA,Kachanova MV,Sergeeva SA

    更新日期:2009-09-01 00:00:00

  • Dynamics of chromosomal aberrations in male mice of various strains during aging.

    abstract::We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Rozenfel'd SV,Togo EF,Mikheev VS,Popovich IG,Zabezhinskii MA,Anisimov VN

    更新日期:2001-05-01 00:00:00

  • Effect of Electroconvulsive Therapy on Cognitive Functions of Rats with Depression-Like Disorders Induced by Ultrasound Exposure.

    abstract::We studied the effect of electroconvulsive therapy on cognitive functions in rats with depression-like disorder caused by exposure to ultrasound of varying frequency (20-45 kHz). Object recognition and Morris water-maze tests revealed no negative effects of the therapy on memory. Moreover, positive effect of therapy w...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Ushakova VM,Zubkov EA,Morozova AY,Gorlova AV,Pavlov DA,Inozemtsev AN,Chekhonin VP

    更新日期:2017-09-01 00:00:00

  • Effect of M2 muscarinic receptor blockade in rats with haloperidol-produced catatonic syndrome.

    abstract::We studied the functional role of individual subtypes of muscarinic cholinoceptors in the pathogenesis of neuroleptic parkinsonism in rats. Blockade of M4 receptors prevented the development of extrapyramidal disorders, which was abolished by simultaneous blockade of M2 receptors. The data suggest that various subtype...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Dagaev SG,Fil'ko OA,Kubarskaya LG,Khrabrova AV,Mukovskii LA,Glukhova RI,Sanotskii VI,Dolgo-Saburov VB

    更新日期:2004-05-01 00:00:00

  • Morphofunctional characteristics of fetoplacental barrier of placental villi during pregnancy complicated by herpes-virus infection.

    abstract::Analysis of placenta homogenate from pregnant women having an episode of herpes-virus infection during the third trimester revealed suppression of Bcl-2 protein activity and increase in caspase 3 concentration. Activity of Bcl-2 protein decreases with increasing the titer of antibodies to herpes virus. Increased caspa...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Lutsenko MT,Andrievskaya IA

    更新日期:2010-10-01 00:00:00

  • The Role of Inducible NOS2 Gene Polymorphism in the Development of Essential Arterial Hypertension.

    abstract::The risk of essential arterial hypertension was assessed in carriers of the NOS2 gene variants (rs1800482 (-954G>C), rs3730017 (C>T)). In subjects carrying C allele (rs1800482), the risk for essential arterial hypertension developing was higher by 1.7 times (OR=1.712, 95%CI 1.07-2.74), while the presence of T-allele (...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Topchieva LV,Balan OV,Korneeva VA,Malysheva IE

    更新日期:2019-11-01 00:00:00

  • Expression of Type I Cannabinoid Receptors at Different Stages of Neuronal Differentiation of Human Fibroblasts.

    abstract::Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced pluripotent stem cells was accompanied by mar...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Bobrov MY,Bezuglov VV,Khaspekov LG,Illarioshkin SN,Novosadova EV,Grivennikov IA

    更新日期:2017-06-01 00:00:00

  • Reparation as a factor contributing to genetic variability of the biological system.

    abstract::Kinetics of DNA synthesis in mitotic cycle of in mouse corneal epithelial cells after γ-irradiation in different S phase points was studied by the method of autoradiography. Normally, S phase of corneal epithelial cells consists of two phases (S1 and S2) separated by an interval without DNA synthesis. Each phase, in t...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Shabalkin IP,Grigor'eva EY,Shabalkin PI,Gudkova MV

    更新日期:2014-11-01 00:00:00

  • Effect of ascorbate and alpha-tocopherol on resistance of beta-carotene to oxidation.

    abstract::The efficiency of ascorbate and alpha-tocopherol as stabilizers of beta-carotene, which is widely used in complex therapy and prevention of some diseases accompanied by oxidative stress, was studied. The latency of induced beta-carotene oxidation linearly depends on ascorbate concentration, while steady-state rate non...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Kozachenko AI,Gurevich SM,Nagler LG

    更新日期:2000-07-01 00:00:00

  • Assessment of therapeutic drug efficiency.

    abstract::The efficiency of drug therapy should be evaluated by not only its directed action on specific organ or target parameter, but also its effects on general regulatory and adaptive status. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 临床试验,杂志文章


    authors: Pokrovskii VM,Kompaniets OG

    更新日期:2008-06-01 00:00:00

  • Bioactive 5-reduced 16 alpha,17 alpha-cyclohexanoprogesterone derivatives weakly interact with proteins of the soluble uterine fraction.

    abstract::We studied competitive activities of 16 alpha,17 alpha-cyclohexano-5 alpha- and 5 beta-dihydroprogesterone in replacing(3)H-progesterone and(3)H-16 alpha,17 alpha-cyclohexano-6 alpha-methylprogesterone from protein complexes. Direct binding of(3)H-5-reduced derivatives with proteins of soluble fractions from rat and r...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Smirnov AN,Pokrovskaya EV,Levina IS,Kulikova LE,Kamernitskii AV,Shevchenko VP

    更新日期:2001-03-01 00:00:00

  • Magnetic Resonance Imaging of Brain Involvement in Dogs Using Paramagnetic Contrast Enhancement with Mn(II)-DCTA P.

    abstract::Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N',N'-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infec...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Ussov WY,Belyanin ML,Bezlepkin AI,Borodin OY,Bobrikova EE,Shimanovskii NL

    更新日期:2016-09-01 00:00:00

  • Morphofunctional State of the Periodontal Tissues in Humans and Rats with Arterial Hypertension.

    abstract::We performed comparative analysis of hemodynamic in the periodontal microcirculatory bed in adolescents with arterial hypertension (AH) and morphological changes in the periodontal tissues of in hypertensive ISIAH rats of comparable biological age. In the periodontal tissues of adolescents with hypertension, the blood...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Kolesnikova LR,Darenskaya MA,Kolesnikova LI,Grebenkina LA,Korytov LI,Batoroev YK,Belinskaya EI,Mikhalevich IM,Kolesnikov SI

    更新日期:2020-10-01 00:00:00

  • Antiaggregant activity of a new benzimidazole derivative.

    abstract::Antiaggregant activity of a new tricyclic benzimidazole derivative, RU-891 compound, was studied on the model of ADP-induced platelet aggregation in vitro and intravascular platelet aggregation in vivo. We evaluated the effect of this substance on blood coagulation potential. Antiaggregant agent acetylsalicylic acid w...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Kucheryavenko AF,Spasov AA,Petrov VI,Anisimova VA

    更新日期:2014-04-01 00:00:00

  • Involvement of Actin Filaments in the Cytotoxic Effect of GD2-Specific Antibodies.

    abstract::Induction of direct cell death is one of the mechanisms of the antitumor effect of GD2-specific antibodies used for the therapy of high-risk neuroblastoma. The mechanisms of the cytotoxic signal triggered by antibody binding to GD2 ganglioside on the surface of the tumor cell remain insufficiently studied. Using inhib...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Doronin II,Kholodenko IV,Zubareva AA,Yarygin KN,Deev SM,Kholodenko RV

    更新日期:2019-02-01 00:00:00

  • Conjugates of aberrant gangliosides in antiglioma vaccine: toxicological assay.

    abstract::We studied sterility and toxicity of vaccine LS1 containing aberrant gangliosides isolated from brain bioptates of 48 patients with gliomas of different malignancy and covalently bound to keyhole limpet hemocyanin. The vaccine was safe. This preparation produced no side effects in experimental animals. Our findings su...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Lombardi V,Shnaar R,Minev B,Misasi R,Gitstsi Kh,Sorice M,Troncone A

    更新日期:2002-10-01 00:00:00

  • Effect of Betula bark extract on spontaneous and induced mutagenesis in mice.

    abstract::Study was performed by counting cells with chromosomal aberrations in C57Bl/6 mice. Bark dry extract was given perorally in doses of 50, 150, 450, and 1500 mg/kg. Mutagens dioxidine and cyclophosphamide were injected intraperitoneally in doses of 200 and 20 mg/kg, respectively. Bark dry extract in doses of 150 and 150...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Zhanataev AK,Presnova GA,Chistyakov AN,Durnev AD

    更新日期:2004-11-01 00:00:00

  • Combined antiherpetic effect of complex preparation "Viferon-eye drops" and modified nucleosides.

    abstract::Ready dosage form (eye drops) prepared on the basis of recombinant alpha2-IFN exhibits high activity towards herpes simplex type 1 virus in vitro. Systematic study of the antiherpesvirus effect of this drug in combination with modified nucleosides showed an inhibitory effect of the synergic type. Combination of IFN pr...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Vyzhlova EN,Andronova VL,Galegov GA,Malinovskaya VV

    更新日期:2006-06-01 00:00:00

  • Dynamic relations between right and left atrial pressure shifts induced by catecholamines.

    abstract::Acute experiments on cats showed that injection of catecholamines induced unidirectional shifts in right and left atrial pressure in 70% cases (these shifts were positive in one half of cats and negative in the other half). In 30% cases, the left and right atrial pressures changed in opposite direction: right atrial p...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Tkachenko BI,Evlakhov VI,Poyasov IZ

    更新日期:2005-01-01 00:00:00

  • Methodological approaches to deciphering the etiological structure of non-nosocomial pneumonia.

    abstract::Comparative analysis of the efficiency of PCR and microbiological methods for deciphering of the etiological structure of non-nosocomial pneumonias demonstrated the diagnostic significance of detecting Streptococcus pneumoniae DNA in the blood, but not sputum. Mechanisms of penetration of S. pneumoniae into the blood ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Artemova LV,Beskhlebnaya VA,Ezhova LG,Kirillov MY,Kravtsov EG,Dalin MV

    更新日期:2003-10-01 00:00:00

  • Structural reactions of the buccal mucosa in diabetic parodontopathy.

    abstract::Pronounced changes in the capillaries, hemodynamic disorders, epitheliocyte degeneration and atrophy develop in the buccal mucosa of patients with types I and II diabetes mellitus in the absence of inflammatory cellular infiltration or with facultative infiltration. The morphogenesis of pathological changes can be reg...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Balakhonov LV,Nepomnyashchikh LM,Aidagulova SV,Bakarev MA,Vlasova LF

    更新日期:2006-11-01 00:00:00

  • Possible Recovery of Manifestation of Prolactin Receptor and Some of Its Target Proteins in the Liver and Kidney Cells of Female Rats after Relief of Cholestasis Complicated and Not Complicated by Hyperprolactinemia.

    abstract::Immunohistochemistry with semi-quantitative analysis of computer images showed that prolactin receptor and cystic fi brosis transmembrane regulator (CFTR) in cholangiocytes of female rats elevated in cholestasis quickly respond to its relief. The effect of hyperprolactinemia on the extent of return of these proteins t...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Aleksandrova MI,Sirotina NS,Smirnova OV

    更新日期:2015-07-01 00:00:00

  • Changes in Functional Activity of Neutrophils and Monocytes Isolated from the Peripheral Blood of Women at Different Phases of the Menstrual Cycle.

    abstract::We studied functional activity of neutrophilic granulocytes and monocytes isolated from the peripheral blood of women during the follicular and luteal phases of the menstrual cycle. It was shown that phagocytic activity of neutrophilic granulocytes increases, their intracellular oxygen-dependent bactericidal activity ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Smirnova TG,Savochkina AY,Dolgushin II,Nikushkina KV,Samuseva IV

    更新日期:2018-12-01 00:00:00

  • Effects of a hydrogen sulfide donor on spontaneous contractile activity of rat stomach and jejunum.

    abstract::We studied the effect of sodium hydrosulfite (NaHS), a donor of hydrogen sulfide (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the prep...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Shafigullin MY,Zefirov RA,Sabirullina GI,Zefirov AL,Sitdikova GF

    更新日期:2014-07-01 00:00:00

  • Role of placenta in the regulation of fetal erythropoiesis.

    abstract::We studied erythropoiesis in newborn infants delivered by mothers with normal pregnancy and gestosis. The effects of placental extracts on hemopoiesis in JCR mice were also evaluated. Our results suggest that the placenta is involved in the regulation of fetal erythropoiesis. The placenta activates fetal erythropoiesi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Evseenko DA,Tsirel'nikov NI

    更新日期:2001-11-01 00:00:00

  • Blood flow in the testes and epididymides of male rats with experimental blockade of testicular veins.

    abstract::Blood flow in reproductive organs was studied during experimental cessation of blood outflow in the testicular vein. This pathological state was accompanied by disturbances of the complex pathogenesis. The major component was autoregulatory focal ischemia, which resulted from the venoarterial response to venous hypert...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Artifeksov SB,Artyukhin AA

    更新日期:2007-06-01 00:00:00

  • Autofluorescence of low-density lipoproteins modified as a result of autooxidation.

    abstract::Autooxidation of low-density lipoproteins during incubation at 37 degrees C was accompanied by accumulation of LPO products, decrease in UV autofluorescence (FUV), and increase in autofluorescence in the visible band (FVIS). The degree of low-density lipoprotein modification was estimated by calculating the FVIS/FUV r...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Aidyraliev RK,Azizova OA,Vakhrusheva TV,Lopukhin YM,Mirrakhimov MM

    更新日期:2006-10-01 00:00:00

  • Morphological study of burn wound healing with the use of collagen-chitosan wound dressing.

    abstract::Experiments on the model of thermal skin burn in rats showed that the use of wound dressing based on collagen-chitosan complex Kollakhit-Bol in local treatment of grade IIIb skin burns increased healing rate by accelerating the formation of granulation and fibrous connective tissues and reducing crust thickness in com...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Kirichenko AK,Bolshakov IN,Ali-Riza AE,Vlasov AA

    更新日期:2013-03-01 00:00:00

  • Extracellular DNA affects NO content in human endothelial cells.

    abstract::Fragments of extracellular DNA are permanently released into the blood flow due to cell apoptosis and possible de novo DNA synthesis. To find out whether extracellular DNA can affect the synthesis of nitric oxide (NO), one of key vascular tone regulators, we studied in vitro effects of three artificial DNA probes with...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章


    authors: Efremova LV,Alekseeva AY,Konkova MS,Kostyuk SV,Ershova ES,Smirnova TD,Konorova IL,Veiko NN

    更新日期:2010-08-01 00:00:00