Abstract：
:We studied the effect of anti-inflammatory cytokine IL-4 (5 μg/kg intraperitoneally) on peripheral blood leukocytes in Wistar rats with various behavioral characteristics during acute emotional stress (1-h immobilization with simultaneous subthreshold electrocutaneous stimulation). IL-4 reduced the differences in blood leukocyte count in rats with various behavioral characteristics, which was related to a significant decrease in this parameter in active animals. IL-4 injection to active animals was accompanied by changes in the leukogram (development of neutrophilia, monocytopenia, and lymphopenia) and had a modulatory effect on leukocyte indexes of cell reactivity. Blood leukocyte count in cytokine-treated animals did not change after stress exposure. IL-4 prevented shifts in leukocyte indexes of cell reactivity, which was found after acute stress exposure. Our results expand current notions on the specific involvement of endogenous immunomodulatory compounds in the realization of adaptive and compensatory processes in mammals during negative emotiogenic exposures.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Pertsov SS,Koplik EV,Kalinichenko LSdoi
10.1007/s10517-015-2814-zsubject
Has Abstractpub_date
2015-03-01 00:00:00pages
595-9issue
5eissn
0007-4888issn
1573-8221journal_volume
158pub_type
杂志文章abstract：:We studied carbohydrate specificity and isotypes of antibodies to BSA-conjugated tetrasaccharide, a repeating unit of the capsular polysaccharide of Streptococcus pneumoniae serotype 14, in mouse polyclonal sera and hybridoma-synthesized products. Natural IgM antibodies to the tetrasaccharide containing epitopes simil...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04376-5
更新日期：2019-02-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-016-3322-5
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1026068208764
更新日期：2003-07-01 00:00:00
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doi：10.1007/s10517-020-04759-z
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abstract：:The mechanisms of extracardiac regulation of heart rate were studied in rats subjected to muscle training on a treadmill with different slope angle (0 degrees , 5.5 degrees up, and 5.5 degrees down). Muscle training on a treadmill sloping down was optimal for the development of training bradycardia in 70-day-old rats....
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0361-1
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doi：10.1007/s10517-017-3896-6
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journal_title：Bulletin of experimental biology and medicine
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doi：
更新日期：2000-10-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1024788309940
更新日期：2003-01-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-019-04628-4
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doi：10.1007/s10517-017-3925-5
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doi：10.1007/s10517-020-04757-1
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-008-0268-2
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doi：10.1007/s10517-014-2397-0
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doi：10.1007/s10517-015-2775-2
更新日期：2015-02-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-016-3478-z
更新日期：2016-09-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1026009517850
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doi：10.1007/s10517-017-3857-0
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
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abstract：:Melatonin administered to intact animals increased glutathione concentration and activities of glutathione peroxidase, glutathione reductase, NADP-isocitrate dehydrogenase, and glucose-6-phosphate dehydrogenase in the liver. In animals with toxic hepatitis melatonin treatment decreased glutathione concentration and en...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0346-7
更新日期：2005-05-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
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abstract：:A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, me...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2546-5
更新日期：2014-06-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-1986-7
更新日期：2013-02-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000042717.00428.e9
更新日期：2004-06-01 00:00:00
