Effect of combination of anticytokine preparations anaferon and artrofoon on immune inflammation in rheumatoid arthritis.

abstract：:Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers. Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented redu...

journal_title：Bulletin of experimental biology and medicine

authors： Zhuikova SE,Sergeev VI,Samonina GE,Myasoedov NF

更新日期：2002-06-01 00:00:00

abstract：:The effects of intranasal pretreatment with antibodies against glutamate on focal penicillin-induced epileptic activity were studied by recording electrocorticogram in non-anesthetized freely moving male Wistar rats. Anticonvulsant effects of intranasal administration of anti-glutamate antibodies (300 μg/kg) 1 h befor...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznetsova LV,Karpova MN,Vetrile LA,Klishina NY

更新日期：2013-09-01 00:00:00

abstract：:For evaluation of the spatial structure of chromatin in nuclei of mesenchymal SC we determined the position of centromeres and individual chromosomes in interphase nucleus of mesenchymal SC. More than 300 nuclei in 7 cultures of mesenchymal SC were analyzed. Centromeres of chromosomes 6, 8, and 11 lie at a longer (0.6...

journal_title：Bulletin of experimental biology and medicine

authors： Lavrov AV,Voldgorn YI

更新日期：2011-08-01 00:00:00

abstract：:Preparation containing ultralow doses of antibodies to stem cell factor considerably activates bone marrow myelopoiesis suppressed by cyclophosphamide. This effect of the preparation is based on stimulation of proliferation of committed hemopoietic precursors and increase in functional activity of adherent elements of...

journal_title：Bulletin of experimental biology and medicine

authors： Stavrova LA,Zyuz'kov GN,Simanina EV,Miroshnichenko LA,Udut EV,Khrichkova TY,Skurikhin EG,Pershina OV,Ermakova NN,Firsova TV,Zhdanov VV,Dygai AM,Gol'dberg ED

更新日期：2009-09-01 00:00:00

abstract：:Animals were immunized with transmissible gastroenteritis virus conjugated with gold nanoparticles. The resultant antibodies had a higher titer than antibodies produced in response to native virus. Immunization with the antigen-colloidal gold complex led to a significant increase of the peritoneal macrophages respirat...

journal_title：Bulletin of experimental biology and medicine

authors： Staroverov SA,Vidyasheva IV,Gabalov KP,Vasilenko OA,Laskavyi VN,Dykman LA

更新日期：2011-08-01 00:00:00

abstract：:The study examined the effect of H2S on the tone of cerebral arteries in rats after global cerebral ischemia/reperfusion injury and cooperation between NO and H2S in the control over cerebral circulation during the postischemic period. In control sham-operated and in experimental rats with ischemia/reperfusion injury,...

journal_title：Bulletin of experimental biology and medicine

authors： Lobov GI,Sokolova IB,Gorshkova OP,Shvetsova ME,Dvoretskii DP

更新日期：2020-03-01 00:00:00

abstract：:Melatonin administered to intact animals increased glutathione concentration and activities of glutathione peroxidase, glutathione reductase, NADP-isocitrate dehydrogenase, and glucose-6-phosphate dehydrogenase in the liver. In animals with toxic hepatitis melatonin treatment decreased glutathione concentration and en...

journal_title：Bulletin of experimental biology and medicine

authors： Pashkov AN,Popov SS,Semenikhina AV,Rakhmanova TI

更新日期：2005-05-01 00:00:00

abstract：:Biopsy specimens from large bronchi of patients with central and peripheral pulmonary cancer were studied. Central cancer was associated with hyperplasia and dysplasia of the epithelium, hyperplasia of glandular compartment, and pronounced immunocompetent cell response. Peripheral cancer was characterized by predomina...

journal_title：Bulletin of experimental biology and medicine

authors： Nepomnyashchikh GI,Levitskii VA,Dolgovykh AK,Naumova LA

更新日期：2002-08-01 00:00:00

abstract：:Comparative identification of cerebral regions activated in men and women during perception of indefinite images was carried out by fMRT and psychological testing. Nine men and nine women aged 20-26 years took part in the study. The volunteers examined simple geometric figures, slightly structurized images (tables fro...

journal_title：Bulletin of experimental biology and medicine

authors： Fyodorov AA,Pervushina ON,Bliznyuk MV,Khoroshilov BM,Melnikov ME,Mazhirina KG,Stark MB,Savelov AA,Petrovsky ED,Kozlova LI

更新日期：2016-07-01 00:00:00

abstract：:Experiments on rat model of stress-induced gastric ulcers revealed marked circulatory disturbances in ulcerated gastric mucosa associated with arteriolar spasm and venous congestion and leading to perivascular edema, diapedesis of erythrocytes, and microhemorrhages. These changes were most pronounced on day 1 after ul...

journal_title：Bulletin of experimental biology and medicine

authors： Khadzhiev OC,Lupal'tsov VI,Simonenkov AP,Klimenko NA,Tatarko SV

更新日期：2000-09-01 00:00:00

abstract：:Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics of cortisol concentration in the adrenal glands was similar, while chan...

journal_title：Bulletin of experimental biology and medicine

authors： Palchikova NA,Kuzminova OI,Utkina NV,Selyatitskaya VG,Shkurupiy VA

更新日期：2008-12-01 00:00:00

abstract：:Chinese hamster cells in culture were blocked in prometaphase by the addition of chloral hydrate. After 2 h the chloral hydrate was removed and the ultrastructural changes in the kinetochore studied during recovery of mitosis. The kinetochore in the blocked cells is a disc measuring 300-350 nm in diameter and 30-35 nm...

journal_title：Bulletin of experimental biology and medicine

authors： Alov IA,Lyubskii SL

更新日期：1975-01-01 00:00:00

abstract：:The stimulatory effect of a local focus of granulation tissue, created in the bone marrow cavity, on reparative osteogenesis after tibial bone fracture was detected in experimental rats by microscopic examination of histological sections, scanning electron microscopy, and X-ray electron probe microanalysis. ...

journal_title：Bulletin of experimental biology and medicine

authors： Ir'yanov YM,Dyuryagina OV

更新日期：2014-05-01 00:00:00

abstract：:The animals were adapted to intermittent hypoxic hypoxia in a flow pressure chamber for 3 days. Each one-day training session consisted of 4 elevations to an altitude of 6000 m for 20 min (15 m/sec, 20-min intervals between assents). Trekrezan (25 mg/kg intraperitoneally) was injected immediately after the end of dail...

journal_title：Bulletin of experimental biology and medicine

authors： Zarubina IV

更新日期：2008-01-01 00:00:00

abstract：:Studies of the effects of Trichoderma harzianum Rifai F-180 culture fluid concentrate containing L-lysine-α-oxidase antitumor enzyme produced by the fungus and the homogenous enzyme, on ultrahazardous bacterium Acidovorax citrulli demonstrated the antibacterial activity of the concentrate. Trichoderma harzianum Rifai ...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova IP,Karimova EV,Shneider YA,Volina EG

更新日期：2018-03-01 00:00:00

abstract：:We studied the effects of stress exposure during the adolescent period of development (SAPD) on the parameters of inflammatory painful response and the level of depression-like behavior in prenatally stressed adult male rats. In addition, we analyzed the effects of selective serotonin (5-HT) reuptake inhibitor fluoxet...

journal_title：Bulletin of experimental biology and medicine

authors： Butkevich IP,Mikhailenko VA

更新日期：2020-07-01 00:00:00

abstract：:Myocardial remodeling in SHR rats with age-related hypertrophy was characterized by elimination of cardiomyocytes, their hypertrophy, and marked increase in the volume of the connective tissue. The count of cardiomyocytes with contracture injuries and subsegmental contractures increased, and pronounced perivascular an...

journal_title：Bulletin of experimental biology and medicine

authors： Lushnikova EL,Nepomnyashchikh LM

更新日期：2003-02-01 00:00:00

abstract：:Pial arteries of different diameter were studied in intact rats and after 6-month modeling of chronic tobacco smoking in rats. Expression of tachykinin NK1 receptors in pial arteries was studied by biomicroscopy and immunohistochemical methods. Chronic tobacco smoking induced considerable reorganizations of the arteri...

journal_title：Bulletin of experimental biology and medicine

authors： Zakharchuk NV,Chertok VM,Nevzorova VA,Gonchar EY

更新日期：2017-07-01 00:00:00

abstract：:Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for prolifera...

journal_title：Bulletin of experimental biology and medicine

authors： Romanko YS,Tsyb AF,Kaplan MA,Popuchiev VV

更新日期：2004-12-01 00:00:00

abstract：:The qualitative and quantitative differences in lipids composition were found in chromatin fractions differing by attachment to the nuclear matrix and transcriptional activity. During liver regeneration after partial hepatectomy Changes in the lipid spectrum of chromatin fractions in G1- and S-phases are associated wi...

journal_title：Bulletin of experimental biology and medicine

authors： Trofimov VA,Dudko AA

更新日期：2006-01-01 00:00:00

abstract：:Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormon...

journal_title：Bulletin of experimental biology and medicine

authors： Arutyunyan AV,Zaloznyaya IV,Kerkeshko GO,Milyutina YP,Korenevskii AV

更新日期：2017-04-01 00:00:00

abstract：:Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did ...

journal_title：Bulletin of experimental biology and medicine

authors： Gruden MA,Davydova TV,Fomina VG,Vetrile LA,Morozova-Roche LA,Sewell RD

更新日期：2017-02-01 00:00:00

abstract：:We studied morphological changes in rat abdominal aorta and vena cava inferior induced by endovascular microwave destruction. This treatment induced thrombosis and necrosis of the vascular walls, but fibrous framework was not completely destroyed. Then we observed irreversible changes in vessels: obliteration, atrophy...

journal_title：Bulletin of experimental biology and medicine

authors： Denisov-Nikol'skii YI,Shafranov VV,Borkhunova EN,Doktorov AA,Mikhaleva LM,Mikhalev AP

更新日期：2002-07-01 00:00:00

abstract：:We studied the dynamics of indexes for the system of endogenous regulation of NO bioavailability. The content of NO synthase inhibitors (monomethylarginine and asymmetric dimethylarginine) in the blood of mice was measured after intraperitoneal injections of a nonionic surfactant poloxamer 407 for 2 and 14 weeks. The ...

journal_title：Bulletin of experimental biology and medicine

authors： Gilinsky MA,Sukhovershin RA,Cherkanova MS

更新日期：2015-11-01 00:00:00

abstract：:The interaction between dopamine D1 and D2 receptors plays a role in immunomodulation. The results of thus interaction depends on the degree of receptor activation with selective agonists in different doses. Combined treatment with agonists of D1 and D2 receptors in high doses had a synergistic effect in the mechanism...

journal_title：Bulletin of experimental biology and medicine

authors： Devoino LV,Al'perina EL,Gevorgyan MM,Cheido MA

更新日期：2006-05-01 00:00:00

abstract：:Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly differed by the magnit...

journal_title：Bulletin of experimental biology and medicine

authors： Sizonov VА,Dmitrieva LE

更新日期：2018-05-01 00:00:00

abstract：:In August rats more resistant to acute stress-induced gastric damage than Wistar rats, preadaptation to nondamaging stress exposure did not prevent damage and even potentiated these damages. By contrast, in Wistar rats such adaptation decreased gastric damage caused by acute stress. Higher initial resistance of August...

journal_title：Bulletin of experimental biology and medicine

authors： Pshennikova MG,Popkova EV,Shimkovich MV

更新日期：2002-10-01 00:00:00

abstract：:Changes in the diurnal light cycle affect the morphofunctional state of the pineal gland. The volume of the nucleus, Golgi apparatus, and mitochondria in pinealocytes decreases after 45-day exposure to bright light. After 90 days, the degree of nuclear polymorphism increased, the specific volume of the Golgi apparatus...

journal_title：Bulletin of experimental biology and medicine

authors： Gerasimov AV,Logvinov SV,Kostyuchenko VP

更新日期：2010-12-01 00:00:00

abstract：:The formation of an ischemic focus in the myocardium is paralleled by autoimmune processes involving immunoglobulins with abnormal thermal solubility, cryoglobulins. Serum levels of cryoglobulins and their complexes were measured in 25 patients with Q-forming myocardial infarction on days 1, 2, 3, 7, and 14 of the dis...

journal_title：Bulletin of experimental biology and medicine

authors： Konstantinova NA,Yeremin II,Konstantinova EV,Karandashov EN,Shostak NA

更新日期：2011-02-01 00:00:00

abstract：:We studied the interaction of the oculomotor, cervical, and vestibular systems using a specially developed technique. A series of two tests were performed on 26 healthy subjects and 42 patients with stages I-II Parkinson's disease receiving and not receiving treatment. In coordinated tests, all amplitude-time characte...

journal_title：Bulletin of experimental biology and medicine

authors： Shvetsov AY,Ivanova EA,Chigalejchik LA,Baziyan BKh

更新日期：2011-11-01 00:00:00