Effect of combination of anticytokine preparations anaferon and artrofoon on immune inflammation in rheumatoid arthritis.

abstract：:The data of genome-wide association analysis suggest that human 6p21.3 chromosomal region (localization of HLA genes) contains polymorphic loci influencing the risk of developing non-Hodgkin's lymphomas. We analyzed association of rs2647012 and rs805288 loci with the risk for non-Hodgkin's malignant lymphomas in the p...

journal_title：Bulletin of experimental biology and medicine

authors： Weiner AS,Berezina OV,Ovchinnikov VS,Surovtseva MN,Voropaeva EN,Pospelova TI,Filipenko ML

更新日期：2014-06-01 00:00:00

abstract：:High doses of phenylephrine and diazepam (1 and 10 mg/kg, respectively) suppressed the development of generalized tonic-clonic pentylenetetrazole-induced convulsions in 86-100% rats, but did not prevent local clonic pentylenetetrazole-induced convulsions. Diazepam in the specified dose produced strong sedation, while ...

journal_title：Bulletin of experimental biology and medicine

authors： Serdyuk SE,Gmiro VE

更新日期：2014-12-01 00:00:00

abstract：:The content of hemopoietic precursors in the bone marrow, its morphological composition, production of hemopoietic growth factors by cells of the hemopoietic microenvironment, erythropoietic activity, and plasma content of endogenous erythropoietin were studied in CBA/CaLac mice with hypoplasia of hemopoiesis induced ...

journal_title：Bulletin of experimental biology and medicine

authors： Dygai AM,Zhdanov VV,Simanina EV,Gur'yantseva LA,Udut EV,Khrichkova TY,Kirienkova EV,Epstein OI,Gol'dberg ED

更新日期：2003-06-01 00:00:00

abstract：:A simple method for the diagnosis of insulin resistance, easily realized in clinical practice, is developed in order to detect patients at a high risk of diseases associated with this condition. The metabolic index is estimated as the proportion of triglycerides and glucose values to quadratic HDL cholesterol value (i...

journal_title：Bulletin of experimental biology and medicine

authors： Roitberg GE,Dorosh ZhV,Sharkhun OO

更新日期：2015-01-01 00:00:00

abstract：:Fucoidans isolated from Fucus evanescens and Laminaria cichorioides kelp can inhibit thrombin and factor Xa of the blood coagulation system. In rats, intravenous injection of fucoidans dose-dependently increased anticoagulant activity of the plasma. Fucoidans can form complexes with protamine sulfate. The observed qua...

journal_title：Bulletin of experimental biology and medicine

authors： Drozd NN,Tolstenkov AS,Makarov VA,Kuznetsova TA,Besednova NN,Shevchenko NM,Zvyagintseva TN

更新日期：2006-11-01 00:00:00

abstract：:Fifty-six primary neuroendocrine lung tumors were examined morphologically and histologically and their apoptosis level was determined. Malignant carcinomas were characterized by increased apoptotic index and enhanced expression ofBcl-2, Bak, p53, and Ki-67 compared to typical carcinoid. However, apoptosis in these tu...

journal_title：Bulletin of experimental biology and medicine

authors： Pal'tsev MA,Demura SA,Kogan EA,Jaques G,Zende B

更新日期：2000-07-01 00:00:00

abstract：:Proinflammatory markers were evaluated in patients with chronic heart failure of ischemic origin and essential hypertension with preserved left-ventricular ejection fraction before and after a 6-month course of simvastatin therapy (20 mg/day). The study was carried out in 125 patients with diastolic dysfunction manife...

journal_title：Bulletin of experimental biology and medicine

authors： Pinchuk TV,Fedulaev YN,Khairetdinova GA,Denisova NN,Chura OV,Logunova IY

更新日期：2014-09-01 00:00:00

abstract：:NAD, cytochrome c, and energostim modulated the fluorescence emission spectrum of trifluoperazine in the solution and in microsomal suspension. The data suggest that NAD and energostim modify structural and conformational characteristics of the dopamine receptor-trifluoperazine complex. These changes probably underlie...

journal_title：Bulletin of experimental biology and medicine

authors： Chikobava EA,Galenko-Yaroshevskii PA,Gurskaya EV,Mamuchishvili IG,Sukoyan GV

更新日期：2004-03-01 00:00:00

abstract：:Comparative analysis of the efficiency of PCR and microbiological methods for deciphering of the etiological structure of non-nosocomial pneumonias demonstrated the diagnostic significance of detecting Streptococcus pneumoniae DNA in the blood, but not sputum. Mechanisms of penetration of S. pneumoniae into the blood ...

journal_title：Bulletin of experimental biology and medicine

authors： Artemova LV,Beskhlebnaya VA,Ezhova LG,Kirillov MY,Kravtsov EG,Dalin MV

更新日期：2003-10-01 00:00:00

abstract：:T cells were most sensitive to cyclophosphamide in DBA/2 mice, while in C57Bl/6 mice both T and B cells were sensitive. The formation of antibody-producing cells and the production of specific antibodies were delayed in DBA/2 mice immunized after pretreatment with antitumor drug. Accumulation of antibody-producing cel...

journal_title：Bulletin of experimental biology and medicine

authors： Masnaya NV,Churin AA,Borsuk OS,Sherstoboev EY

更新日期：2003-04-01 00:00:00

abstract：:A new phenomenon is discovered: Helicobacter pylori suppressed production of superoxide radical by neutrophils, while intracellular production of oxygen radicals is considerably activated. This phenomenon seems to play an important role in Helicobacter modulation of the inflammatory process in the stomach and persiste...

journal_title：Bulletin of experimental biology and medicine

authors： Barsukov AA,Zhukhovitskii VG,Shcherbakova EG,Zemskov VM,Diashev AN

更新日期：2005-01-01 00:00:00

abstract：:Adhesion activity of L. acidophilus NK1, L. fermentum 90 TS4, and C. albicans 506 B on female vaginal epithelium was studied. Adhesion of various lactobacillus species was hormone-dependent. Adhesion of C. albicans 506 B was not associated with estrogen level. The effects of synthetic drugs and phytopreparations used ...

journal_title：Bulletin of experimental biology and medicine

authors： Rybas YA,Bustamante RA,Kravtsov EG,Tchernitchin AN,Dalin MV

更新日期：2012-07-01 00:00:00

abstract：:Hemopoietic islets, associations of stromal (macrophages, fibroblasts) and blood (including stem) cells, are structural and functional units of the bone marrow. We studied cellular and molecular processes developing following short-term (1 h) contact of hemopoietic islets with ferromagnetic nanoparticles in a multicel...

journal_title：Bulletin of experimental biology and medicine

authors： Novitsky VA,Khlusov IA,Ryazantseva NV,Chechina OE,Feduschak TA,Ermakov AE,Uimin MA

更新日期：2011-08-01 00:00:00

abstract：:Electron microscopy of the pineal gland in gamma-irradiated rats treated with epithalon revealed ultrastructural signs attesting to enhancement of its functional activity. ...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VK,Yakovleva ND,Popuchiev VV,Kvetnoi IM,Manokhina RP

更新日期：2001-01-01 00:00:00

abstract：:A direct relationship between the weights of the brain and hemisphere and parameters characterizing the development of the cortex and its neurons in intact newborn rats was revealed. Parameters of brain development in newborn rats correlate with 3beta-hydroxysteroid dehydrogenase activity in the adrenal zona glomerulo...

journal_title：Bulletin of experimental biology and medicine

authors： Ryzhavskii BY,Matveeva EP,Baranova SN

更新日期：2005-12-01 00:00:00

abstract：:Antioxidant properties of recombinant peroxiredoxin-6 and chimeric protein PSH combining peroxidase and superoxide dismutase activities were studied on the model of retrograde perfusion of isolated rat heart under conditions of H2O2-induced oxidative stress. The exogenous antioxidant proteins exhibited cardioprotectiv...

journal_title：Bulletin of experimental biology and medicine

authors： Karaduleva EV,Mubarakshina EK,Sharapov MG,Volkova AE,Pimenov OY,Ravin VK,Kokoz YM,Novoselov VI

更新日期：2016-03-01 00:00:00

abstract：:We studied a combined effect of subcomponents of vitamin B complex on the growth, development, and death of human embryonic brain-derived cells (E90) cultured using a modified method of Matson. Cell death was detected by trypan blue staining. According to our results, vitamin B-complex in low-doses promote the develop...

journal_title：Bulletin of experimental biology and medicine

authors： Danielyan KE,Abramyan RA,Galoyan AA,Kevorkian GA

更新日期：2011-09-01 00:00:00

abstract：:Natural response to hypoxia critically depends on rapid stabilization of hypoxia-inducible factor (HIF). Under normoxic conditions, HIF-prolyl hydroxylases mark α-subunits of HIF for degradation, while hypoxia results in stabilization of HIF-α. Oxyquinoline derivatives suppress activity of HIF-prolyl hydroxylases lead...

journal_title：Bulletin of experimental biology and medicine

authors： Knyazev EN,Petrov VA,Gazizov IN,Gerasimenko TN,Tsypina IM,Tonevitsky AG,Sukhikh GT

更新日期：2019-01-01 00:00:00

abstract：:Analysis of planned endomyocardial biopsy specimens of heart allotransplants from 22 recipients revealed signs of humoral type rejection (slight, medium, and severe) presenting as fixation of IgG, IgM, and complement components (C3, C4d) in 61 of 63 sections. Permanent presence of rejection signs attests to rheumatoid...

journal_title：Bulletin of experimental biology and medicine

authors： Beletskaya LV,Kupriyanova AG,Kormer AY,Mironkov BL,Kazakov EN,Shumakov VI

更新日期：2006-09-01 00:00:00

abstract：:We studied brown adipose tissue isolated from mice receiving 20% ethanol as a single source of fluid. In vitro O2 utilization by brown adipose tissue decreased after one month of forced alcohol intake, but surpassed the control after 3 months of ethanol drinking. The absolute and relative weight of brown adipose tissu...

journal_title：Bulletin of experimental biology and medicine

authors： Elsukova EI,Medvedev LN,Kudryavtseva NA

更新日期：2001-12-01 00:00:00

abstract：:Comparative study of cultured human bone marrow and adipose tissue (lipoaspirate) mesenchymal stem cells was carried out. The main morphological parameters, proliferative activity, expression of surface and intracellular markers of these cells were characterized. Flow cytofluorometry and histological staining showed t...

journal_title：Bulletin of experimental biology and medicine

authors： Romanov YA,Darevskaya AN,Merzlikina NV,Buravkova LB

更新日期：2005-07-01 00:00:00

abstract：:Electron microscopic study of changes in cultured cells caused by Vibrio cholerae recombinant hemagglutinin/protease (HA/P) showed significant structural changes, most pronounced in HeLa and L-929 cells not forming a compact monolayer with tight junctions between the cells: formation of numerous vesicles on the cell s...

journal_title：Bulletin of experimental biology and medicine

authors： Sayamov SR,Monakhova EV,Fedorenko GM,Tkacheva TI,Markina OV,Alekseeva LP,Pisanov RV,Bardakhchian EA

更新日期：2012-02-01 00:00:00

abstract：:Clinical and laboratory studies were carried out in 38 pregnant women with antiphospholipid syndrome. Increased functional activity of platelets and decreased protein-producing function of the placenta were observed starting from the early terms of gestation. These disorders were followed by the development of hyperco...

journal_title：Bulletin of experimental biology and medicine

authors： Bogdanovich RN,Chikalovets IV

更新日期：2002-10-01 00:00:00

abstract：:Changes in ECG parameters were studied in pregnant rats exposed to acute hypobaric hypoxia during the period of organogenesis (gestation days 9 to 10). Rats with low, medium, and high tolerance to hypoxia exhibited pronounced autonomic nervous system imbalance, which become apparent as a loss of correlation between va...

journal_title：Bulletin of experimental biology and medicine

authors： Maslova MV,Graf AV,Maklakova AS,Krushinskaya YV,Sokolova NA,Koshelev VB

更新日期：2005-02-01 00:00:00

abstract：:Experiments on rats showed that neurospecific protein preparations reduce the severity of neurological deficit, restore the structure of individual behavior of the animals with different hypoxia tolerance, and exert antioxidant action during chronic ischemic damage to the brain unfolding during the early and late phas...

journal_title：Bulletin of experimental biology and medicine

authors： Zarubina IV,Shabanov PD

更新日期：2016-02-01 00:00:00

abstract：:The linear parameters and number of Langerhans islets were evaluated in rats with alloxaninduced diabetes mellitus after transplantation of fetal pancreatic tissue to the anterior chamber of the eye. The islets significantly increased in size by week 3 after surgery and a trend to an increase in their number was obser...

journal_title：Bulletin of experimental biology and medicine

authors： Kulikov DA,Kulikov AV,Arkhipova LV,Smirnova GN,Dreval' AV,Tikhonova LP,Gaivoronskii IV,Sukhikh GT

更新日期：2015-01-01 00:00:00

abstract：:We performed a comparative study of the localization, distribution, metabolic activity, and surface properties of human bone marrow mesenchymal stromal cells after static and perfusion seeding to macroporous alginate cryogels. A simple perfusion system for mesenchymal stromal cell seeding to macroporous alginate cryog...

journal_title：Bulletin of experimental biology and medicine

authors： Petrenko YA,Ivanov RV,Lozinsky VI,Petrenko AY

更新日期：2011-02-01 00:00:00

abstract：:Reductase activity of 17beta-hydroxysteroid oxidoreductase in biopsy specimens of prostatic cancer and benign hyperplasia, and prostatic intraepithelial neoplasia and serum concentrations of testosterone, 5alpha-dihydrotestosterone, 4-androstene-3,17-dione were compared in patients and healthy individuals. Reductase a...

journal_title：Bulletin of experimental biology and medicine

authors： Degtyar VG,Babkina TV,Kazantseva IA,Morozov AP,Trapeznikova MF,Kushlinskii NE

更新日期：2005-06-01 00:00:00

abstract：:Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD-H-2 by succinic semialdeyde a...

journal_title：Bulletin of experimental biology and medicine

authors： Zubovskaya AM,Ostrovskaya RU,Tsybina NM

更新日期：1975-01-01 00:00:00

abstract：:Pharmacokinetics of GVS-111, a new acylprolyldipeptide with nootropic properties and its penetration across the blood-brain barrier were studied in rats using HPLC. It was found that the dipeptide is absorbed in the gastrointestinal tract, enters the circulation, and penetrates through the blood-brain barrier in an un...

journal_title：Bulletin of experimental biology and medicine

authors： Boiko SS,Ostrovskaya RU,Zherdev VP,Korotkov SA,Gudasheva TA,Voronina TA,Seredenin SB

更新日期：2000-04-01 00:00:00