Changes in blood cytochemical indexes in animals during pregnancy and after labor.

abstract：:T cells were most sensitive to cyclophosphamide in DBA/2 mice, while in C57Bl/6 mice both T and B cells were sensitive. The formation of antibody-producing cells and the production of specific antibodies were delayed in DBA/2 mice immunized after pretreatment with antitumor drug. Accumulation of antibody-producing cel...

journal_title：Bulletin of experimental biology and medicine

authors： Masnaya NV,Churin AA,Borsuk OS,Sherstoboev EY

更新日期：2003-04-01 00:00:00

abstract：:We studied the effects of optical (dd-, ll-, dl-, and ld-dipeptides with alpha-bond, EW) structural isomers and cyclic (dd-, ll-, dl-, and ld-dipeptides with gamma-bond, iEW) analogs of Glu-Trp synthetic dipeptide on the population of normal hemopoietic stem cells. Dipeptides containing lGlu (lGlu-lTrp, lGlu-dTrp) inj...

journal_title：Bulletin of experimental biology and medicine

authors： Semina OV,Semenets TN,Zamulaeva IA,Selivanova EI,Malyutina YV,Saenko AS,Deigin VI

更新日期：2006-02-01 00:00:00

abstract：:Structure of arteries of different diameter in early and late periods of hypertension caused by experimental coarctation of the aorta was studied by histological and morphometric methods. Blood pressure was measured directly via catheterization of the common carotid artery and used for evaluation of hemodynamic in the...

journal_title：Bulletin of experimental biology and medicine

authors： Gansburgsky AN,Jaltsev AV

更新日期：2012-07-01 00:00:00

abstract：:According modern biological hypotheses of the pathogenesis of affective disorders, hypothalamic-pituitary-adrenal axis dysfunction play a special role in the pathogenesis of this condition. Our study shows that the range of neuroprotective neurosteroids is gender- and nosology-dependent. Patients with affective disord...

journal_title：Bulletin of experimental biology and medicine

authors： Levchuk LA,Vyalova NM,Ivanova SA,Simutkin GG,Lebedeva EV,Bokhan NA

更新日期：2015-03-01 00:00:00

abstract：:The effects of opioids (morphine and fentanyl) on the function of mechanoreceptive respiration regulatory loop were demonstrated. In most opioid-treated rats (74% cases) vagotomy was followed by apneustic respiration with inspiration pause. Excess of opioids in rat CNS produced minor disturbances in the respiration rh...

journal_title：Bulletin of experimental biology and medicine

authors： Tarakanov IA,Tikhomirova LN,Safonov VA

更新日期：2005-04-01 00:00:00

abstract：:Changes in bile ducts in cholestasis are characterized by activation of proliferation and hypertrophy of cholangiocytes and degenerative and necrobiotic changes in ductal epithelium. Long-term cholestasis led to massive necrosis of cholangiocytes. Inflammatory changes in the choledochal mucosa were most pronounced in ...

journal_title：Bulletin of experimental biology and medicine

authors： Dreval' AA,Perminova GI,Kuznetsov NA,Sokolov AA,Laberko LA,Ryzhkova LV

更新日期：2002-04-01 00:00:00

abstract：:Expression of glucocorticoid receptor protein in the hippocampus and frontal cortex of male and female rats during the 1st, 2nd, and 3rd weeks of life was studied by Western blot hybridization. In the frontal cortex, the concentration of receptor protein progressively increased from the 1st to the 3rd week of life; in...

journal_title：Bulletin of experimental biology and medicine

authors： Ordyan NE,Galeeva AY,Pivina SG

更新日期：2008-08-01 00:00:00

abstract：:Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. beta-Adrenoceptor blockers without intrinsic sympathomimetic activity n...

journal_title：Bulletin of experimental biology and medicine

authors： Fedorov VN,Sal'nikov EV,Sidorov AV,Bogatushin AV,Fateev MM

更新日期：2006-01-01 00:00:00

abstract：:Viability of keratinocytes of HaCaT immortalized line incubated with sodium dodecyl sulfate for 3 min, 1 and 48 h, was studied by light microscopy, MTT test, and neutral red absorption test. The IC50 values were determined for each of the studied lengths of exposure. HaCaT cells exhibited a dose-dependent decrease of ...

journal_title：Bulletin of experimental biology and medicine

authors： Rusanov AL,Luzgina NG,Lisitsa AV

更新日期：2017-06-01 00:00:00

abstract：:The effect of p-tyrosol on the spontaneous level of DNA damage in the cells of the bone marrow, liver, kidney, and rectum of mice (series I) and on the genotoxic effects of cytostatic drugs with different mechanisms of action in rat testicular cells (series II) was studied by DNA comet assay on C57BL/6 mice. p-Tyrosol...

journal_title：Bulletin of experimental biology and medicine

authors： Borovskaya TG,Vychuzhanina AV,Grigor'eva VA,Kollantay OV,Goldberg VE,Dygai AM

更新日期：2020-06-01 00:00:00

abstract：:We studied changes in cerebral and central hemodynamics during active orthostatic load in 26 healthy men aging 20-26 years. Two types of central hemodynamics were revealed: progressive increase in blood pressure throughout the test (type 1) or initial blood pressure increase followed by its decrease with maximum incre...

journal_title：Bulletin of experimental biology and medicine

authors： Zabolotskikh NV

更新日期：2008-05-01 00:00:00

abstract：:Effects of pentobarbital on spectral characteristics and phase ratios of wave oscillations of the cardiac contraction period (RR interval) and time of atrioventricular conduction (AV interval) were studied in experiments of cats. Pentobarbital moderately reduced the mean values of both intervals and significantly redu...

journal_title：Bulletin of experimental biology and medicine

authors： Alipov NN,Sergeeva OV,Smirnov VM,Kuznetsova TE,Bobrova NA

更新日期：2006-03-01 00:00:00

abstract：:Muscular dystrophy is a common multisystem disease, which results from the impairment of alternative splicing. An increase in the number of unstable CTG and CCTG repeats in untranslated regions of the DMPK and ZNF9 genes is followed by dysregulation of RNA-binding proteins. Further changes are followed by dysfunction ...

journal_title：Bulletin of experimental biology and medicine

authors： Tonevitsky EA,Trushkin EV

更新日期：2009-06-01 00:00:00

abstract：:Behavioral responses of 90-day-old male offspring from female Wistar rats exposed to restraint stress during the last week of pregnancy were studied in the formalin test. Specific biphasic behavioral response characterized acute (phase 1) and persistent tonic pain (phase 2). The intensity of nociceptive responses (eva...

journal_title：Bulletin of experimental biology and medicine

authors： Butkevich IP

更新日期：2002-02-01 00:00:00

abstract：:We performed a complex morphological analysis of atherosclerotic plaques obtained from 68 men with coronary atherosclerosis during coronary bypass surgery with endarterectomy. The expression of MMP-2 and MMP-9, collagen IV, CD31, CD34, factor VIII, and of smooth muscle cell actin was measured in the samples by morphom...

journal_title：Bulletin of experimental biology and medicine

authors： Murashov IS,Volkov AM,Kazanskaya GM,Kliver EE,Savchenko SV,Klochkova SV,Lushnikova EL

更新日期：2018-10-01 00:00:00

abstract：:Experiments on the model of mouse BCG-induced granulomatous showed that the content of glycosaminoglycans and proteoglycans in the extracellular matrix of the liver and lungs are changed at the early stages of inflammation (days 3 and 30 postinfection) before cell destruction in the organs begins. This is related to d...

journal_title：Bulletin of experimental biology and medicine

authors： Kim LB,Shkurupy VA,Putyatina AN

更新日期：2015-01-01 00:00:00

abstract：:Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K(+) after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive "stationary" component, and a lower "regulatory" component sensitive to ouabaine, furosemi...

journal_title：Bulletin of experimental biology and medicine

authors： Volkov EM,Sabirova AR,Nurullin LF,Zefirov AL

更新日期：2006-12-01 00:00:00

abstract：:We studied the effect of μ-opioid receptor ligands on anxious and depressive behavior of rats. Intragastric administration of loperamide and methylnaloxone reduced animal anxiety evaluated by an increase in the number of entries into and time spent in open arms of the elevated plus-maze. μ-Opioid receptor agonist lope...

journal_title：Bulletin of experimental biology and medicine

authors： Sudakov SK,Bashkatova VG,Kolpakov AA,Trigub MM

更新日期：2010-09-01 00:00:00

abstract：:We evaluated the concentration dependence and time dependence of the effect of nitroglycerine on intracellular content of cAMP, cGMP, and free Ca2+. It was shown that after norepinephrine stimulation, nitroglycerine exhibited calcium-blocking activity in lower concentrations (starting from 10(-7) M). Under conditions ...

journal_title：Bulletin of experimental biology and medicine

authors： Dukhanin AS,Shimanovskii NL

更新日期：2006-05-01 00:00:00

abstract：:Hemopoietic islets, associations of stromal (macrophages, fibroblasts) and blood (including stem) cells, are structural and functional units of the bone marrow. We studied cellular and molecular processes developing following short-term (1 h) contact of hemopoietic islets with ferromagnetic nanoparticles in a multicel...

journal_title：Bulletin of experimental biology and medicine

authors： Novitsky VA,Khlusov IA,Ryazantseva NV,Chechina OE,Feduschak TA,Ermakov AE,Uimin MA

更新日期：2011-08-01 00:00:00

abstract：:Rarely repeated episodes of 1-h immobilization in rats were accompanied by an increase in the content of molecular products of lipid peroxidation and decrease in the amount of oxidatively modified proteins. Monoamine oxidase B inhibitor deprenyl prevented the poststress activation of lipid peroxidation. ...

journal_title：Bulletin of experimental biology and medicine

authors： Tseilikman VE,Sinitsky AI,Poyarkov KA,Vojdaev EV

更新日期：2009-12-01 00:00:00

abstract：:In the presence of Fe3+ cation, S-nitrosoglutathione (GSNO) loses the potency to inhibit catalase in the system containing hemoglobin (an NO trap) with iron chelator or -SH inhibitor (a "sulfhydric poison" Hg2+). In the absence of hemoglobin, the inhibitory potency is retained in both cases. These properties are chara...

journal_title：Bulletin of experimental biology and medicine

authors： Titov VY,Osipov AN,Ibragimova LG,Petrov VA,Dolgorukova AM

更新日期：2019-11-01 00:00:00

abstract：:We analyzed association of potentially regulatory polymorphisms (rs590352, rs11542583, rs3829202, rs207258, and rs4796672) with breast cancer. A significant association was found between this disease and rs2072580T>A (p=0.001) located in the overlapping promoter regions of the SART3 and ISCU genes. In women with AA an...

journal_title：Bulletin of experimental biology and medicine

authors： Degtyareva AO,Leberfarb EY,Efimova EG,Brusentsov II,Usova AV,Lushnikova EL,Merkulova TI

更新日期：2020-05-01 00:00:00

abstract：:Cytochrome p450-mediated metabolism of GRS (indolinone antiaggregant) and its effects on activities of cytochrome p450 isoenzymes were studied. Inhibition of 6 isomers of cytochrome p450 in human liver microsomes was studied with the use of specific substrates. It was found that human liver cytochrome p450 enzymes cou...

journal_title：Bulletin of experimental biology and medicine

authors： Bykov VV,Leonov KA,Serebrov VY,Chernysheva GA,Smol'yakova VI,Solov'ev MA,Udut EV,Fisenko VP,Udut VV

更新日期：2020-04-01 00:00:00

abstract：:The production of blood radicals and activity of superoxide dismutase in erythrocytes increased in rats with contact burn trauma (20%). In animals with burn trauma antioxidant activity of the plasma was much lower, while myeloperoxidase content in the lung tissue and epidermis was higher than in control rats. The comp...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhal'chik EV,Ivanova AV,Anurov MV,Titkova SM,Pen'kov LY,Korkina LG

更新日期：2004-09-01 00:00:00

abstract：:We studied ultrastructural reorganization of the colon transplant in delayed period after esophagoplasty. It was found that during functioning of the artificial esophagus, a complex of adaptive and pathologic processes occurs in the mucosa. Focal sclerosis of the mucosa and slight epithelial degeneration with hyperpla...

journal_title：Bulletin of experimental biology and medicine

authors： Nepomnyashchikh LM,Lapii GA,Chikinev YV,Sudovykh IE,Tokmakov IA

更新日期：2012-06-01 00:00:00

abstract：:A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, me...

journal_title：Bulletin of experimental biology and medicine

authors： Kuleshina ON,Kozlov LV,Cheremnykh EG

更新日期：2014-06-01 00:00:00

abstract：:Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explain...

journal_title：Bulletin of experimental biology and medicine

authors： Titov VN,Sazhina NN

更新日期：2014-12-01 00:00:00

abstract：:Noopept, a peptide analog of piracetam, enhanced phagocytic activity of mouse peritoneal macrophages, stimulated humoral and cellular immune response to various antigens, and markedly increased spontaneous proliferative activity of splenocytes. In animals with secondary immune deficiency caused by cyclophosphamide, no...

journal_title：Bulletin of experimental biology and medicine

authors： Kovalenko LP,Shipaeva EV,Alekseeva SV,Pronin AV,Durnev AD,Gudasheva TA,Ostrovskaja RU,Seredenin SB

更新日期：2007-07-01 00:00:00

abstract：:Neurospecific proteins S-100 and GFAP were measured in the serum of 145 patients with neural tumors and 69 healthy individuals. In patients with glyoblastomas, the concentrations of S-100 and GFAP were significantly higher than in patients with anaplastic astrocytomas, benign meningiomas, and brain metastases and in h...

journal_title：Bulletin of experimental biology and medicine

authors： Lyubimova NV,Toms MG,Popova EE,Bondarenko YV,Krat VB,Kushlinskii NE

更新日期：2011-04-01 00:00:00