Abstract:
:Coagulation and optical (based on chromogenic substrate) methods were employed to examine antithrombin activity of erythrocytes and erythrocyte-derived microvesicles isolated days 7, 14, 21, and 28 on erythrocyte storage. The erythrocyte-derived microvesicles decelerated fibrin clot formation from fibrinogen in the presence of exogenous thrombin both with and without heparin. Microvesicles reduced optical density of chromogenic substrate. These data suggest that erythrocyte-derived microvesicles display a prominent antithrombin activity, which significantly increases during erythrocyte storage.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Levin GY,Sukhareva EGdoi
10.1007/s10517-017-3696-zsubject
Has Abstractpub_date
2017-04-01 00:00:00pages
718-721issue
6eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3696-zjournal_volume
162pub_type
杂志文章abstract::Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K(+) after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive "stationary" component, and a lower "regulatory" component sensitive to ouabaine, furosemi...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-006-0461-0
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abstract::Micro- and nanomolar concentrations of ganglioside GM1 improved viability of neuronal PC12 cells under conditions of oxidative stress and reduced H2O2-induced ROS accumulation in these cells. These effects were more pronounced at micromolar concentrations. GM1 in concentrations of 100 nM and 10 μM significantly and su...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-015-3026-2
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abstract::The hypolipidemic effect of Kwai, a preparation based on garlic powder (Allium sativum), depended on the initial content of cholesterol and/or triglycerides. This effect was most pronounced in patients with coronary heart disease with initial cholesterol >7.0 mmol/liter and triglyceride >1.92 mmol/liter. After treatme...
journal_title:Bulletin of experimental biology and medicine
pub_type: 临床试验,杂志文章
doi:10.1023/a:1024955023300
更新日期:2003-05-01 00:00:00
abstract::Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of this phenomenon w...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
abstract::We revealed a significant positive correlation between the concentrations of tissue VEGF and its receptor VEGFR2 in the primary tumor. The degree and direction of changes in the content of VEGF and VEGFR2 in cytosols of tumors from patients with locally spread breast cancer during the preoperation therapy depended on ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-008-0061-2
更新日期:2008-02-01 00:00:00
abstract::Glutathione S-transferase activity increased in rats with acute pancreatitis: 2.2 times on day 2, 2-fold on day 4, and 1.5 times on day 10. Inducers of microsomal enzymes aroclor 1254 and phenobarbital notably inhibited glutathione S-transferase activity in animals with experimental pancreatitis on days 2-4 of the dis...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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abstract::The dynamics of blood concentrations of reactive oxygen species and LPO products in patients with thermal injuries of different severity was studied. Monitoring of these parameters by chemiluminescent and spectrophotometric techniques helps to predict the course of burn shock and prevent complications. Erysod (0.004% ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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journal_title:Bulletin of experimental biology and medicine
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journal_title:Bulletin of experimental biology and medicine
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abstract::We studied the effect of 20 standard L-amino acids on proliferation of the nervous, cardiovascular, urogenital, digestive, and immune system tissues from young and old animals in organotypic cultures. The effect of amino acids on tissue culture proliferation depended on their origin and animal age. ...
journal_title:Bulletin of experimental biology and medicine
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doi:10.1007/s10517-013-2200-7
更新日期:2013-08-01 00:00:00
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更新日期:2015-04-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-010-0855-x
更新日期:2009-12-01 00:00:00
abstract::The effects of LPS from E. coli on DNA-binding activities of PPARα and PPARγ in the liver and immune system parameters of were studied in hypertensive ISIAH rats and normotensive WAG rats. In ISIAH rats characterized by low basal level of PPARα, PPARγ, and HDL, the response of the peripheral immune system compartment ...
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更新日期:2012-02-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章,随机对照试验
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journal_title:Bulletin of experimental biology and medicine
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更新日期:2017-05-01 00:00:00
abstract::The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of mesenchymal precursor cell function by the fibroblast growth factor was studied. The levels of fibroblast colony- and cluster formation and proliferative activity of mesenchymal precursors increased in response to J...
journal_title:Bulletin of experimental biology and medicine
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abstract::We studied anticonvulsant effects of combined treatment with citicoline, a nootropic substance with neuroregenerative and neuroprotective activities, and valproate, an antiepileptic agent widely used in the treatment of epilepsy, on the model of pentylenetetrazole-induced (75 mg/kg, intraperitoneally) acute generalize...
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journal_title:Bulletin of experimental biology and medicine
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abstract::Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormon...
journal_title:Bulletin of experimental biology and medicine
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journal_title:Bulletin of experimental biology and medicine
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abstract::Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for prolifera...
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journal_title:Bulletin of experimental biology and medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-10-01 00:00:00