Abstract:
:Experiments on rats showed that blockade of hyperpolarization-activated currents moderates tachycardia induced by beta-adrenoceptor agonist isoproterenol and potentiates the increase in stroke volume produced by this agonist. Electrical stimulation of the vagus nerve against the background of isoproterenol treatment augmented bradycardia and increased stroke volume. Blockade of hyperpolarization-activated currents followed by application of isoproterenol moderated vagus-induced bradycardia and had no effect on the dynamics of stroke volume.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Zefirov TL,Ziyatdinova NI,Gainullin AA,Zefirov ALdoi
10.1023/a:1019884931598subject
Has Abstractpub_date
2002-05-01 00:00:00pages
425-7issue
5eissn
0007-4888issn
1573-8221journal_volume
133pub_type
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