Blockade of hyperpolarization-activated channels modifies the effect of beta-adrenoceptor stimulation.

Abstract:

:Experiments on rats showed that blockade of hyperpolarization-activated currents moderates tachycardia induced by beta-adrenoceptor agonist isoproterenol and potentiates the increase in stroke volume produced by this agonist. Electrical stimulation of the vagus nerve against the background of isoproterenol treatment augmented bradycardia and increased stroke volume. Blockade of hyperpolarization-activated currents followed by application of isoproterenol moderated vagus-induced bradycardia and had no effect on the dynamics of stroke volume.

journal_name

Bull Exp Biol Med

authors

Zefirov TL,Ziyatdinova NI,Gainullin AA,Zefirov AL

doi

10.1023/a:1019884931598

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

425-7

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

133

pub_type

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