Trimetazidine as indirect antioxidant.

abstract：:The gene expression profiles of MDA-MB-231 cell line of breast cancer and xenografts derived from this tumor in murine model were analyzed using GeneChip Human Transcriptome array 2.0 platform (Affymetrix). A more than 1000-fold increase in the MIR1973 gene expression was observed in the xenografts compared to the ori...

journal_title：Bulletin of experimental biology and medicine

authors： Fomicheva KA,Knyazev EN,Mal'tseva DV

更新日期：2017-09-01 00:00:00

abstract：:Oxygen-dependent processes in peripheral blood monocytes were intensified in patients with metabolic cardiovascular syndrome. This was manifested in increased production of O(2)(*-) and NO. Among metabolic factors (cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols...

journal_title：Bulletin of experimental biology and medicine

authors： Suslova TE,Gruzdeva OV,Fedorova TS,Karpov RS

更新日期：2004-05-01 00:00:00

abstract：:We studied the dynamics of indexes for the system of endogenous regulation of NO bioavailability. The content of NO synthase inhibitors (monomethylarginine and asymmetric dimethylarginine) in the blood of mice was measured after intraperitoneal injections of a nonionic surfactant poloxamer 407 for 2 and 14 weeks. The ...

journal_title：Bulletin of experimental biology and medicine

authors： Gilinsky MA,Sukhovershin RA,Cherkanova MS

更新日期：2015-11-01 00:00:00

abstract：:The effect of streptozotocin-induced diabetes mellitus on some parameters of energy metabolism and functional status of cell membranes was studied in experiments on rats. It was found that the development of diabetes mellitus is associated with dramatic changes in the metabolism of blood cells and kidney tissue: inhib...

journal_title：Bulletin of experimental biology and medicine

authors： Mikaelian NP,Gurina AE,Terent'ev AA

更新日期：2013-03-01 00:00:00

abstract：:We studied properties of cloned BACE mRNA (beta-site of the enzyme cleaving amyloid precursor protein) and evaluated the possibility of using this clone for identification and/or prediction of neurodegenerative disorders associated with cholinergic deficiency. Wistar rats subjected to immunohistochemical destruction o...

journal_title：Bulletin of experimental biology and medicine

authors： Lushchekina EA,Bigl M,Apelt J,Lange-Dohna C,Rossner S,Schliebs R

更新日期：2002-09-01 00:00:00

abstract：:The parameters of thermal dependence of H+ transport into human erythrocytes in the presence of furosemide were measured. The relationship between these changes and function of band 3 protein of the erythrocyte membrane is discussed. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mishchenko AA,Irzhak LI

更新日期：2004-07-01 00:00:00

abstract：:We compared the effect of xymedon (100 mg/kg) and Mexidol (50 mg/kg) on morphometric parameters of erythrocytes and oxygen-transporting function of hemoglobin in rats with Walker-256 carcinoma treated with docetaxel (15 mg/kg once intraperitoneally on day 11 after tumor cells transplantation). Xymedon and Mexidol were...

journal_title：Bulletin of experimental biology and medicine

authors： Siprov AV,Solovyova MA

更新日期：2017-11-01 00:00:00

abstract：:Effect of one-day and chronic (3 week) drinking of 0.1% caffeine as a single source of fluid on anxiety in rats with different anxiety level (either genetically determined or individually acquired) was studied. When housed in groups, Fisher-344 rats had a significantly higher anxiety level than WAG/G rats. When the ra...

journal_title：Bulletin of experimental biology and medicine

authors： Sudakov SK,Medvedeva OF,Rusakova IV,Figurina IB

更新日期：2001-12-01 00:00:00

abstract：:We performed a fluorescent microscopic examination of human and animal aortic grafts at different stages of decellularization. Treatment of aortic grafts with trypsin/EDTA solution for 48 h leads to their complete decellularization and preserved the connective tissue fiber backbone, which gains a netlike structure. Th...

journal_title：Bulletin of experimental biology and medicine

authors： Subbotin DV,Larionov PM,Sergeevichev DS,Subbotina OA,Zaitsev GS,Novruzov RB,Orishich AM,Malov AN,Maslov NA,Rozhin IA,Lushnikova EL,Nepomnyashih LM

更新日期：2009-10-01 00:00:00

abstract：:Reversible cerebral ischemia of medium severity was reproduced in male Wistar rats by bilateral occlusion of the common carotid arteries. Solid-phase structures (anisomorphons) were obtained by marginal dehydration of the serum. Small focal isotropic defects in the serum anisomorphon texture were found in 100% cases d...

journal_title：Bulletin of experimental biology and medicine

authors： Shatokhina SN,Aleksandrin VV,Shatokhina IS,Kubatiev AA,Shabalin VN

更新日期：2018-01-01 00:00:00

abstract：:The involvement of the studied signal cascades in the regulation of erythropoietin production by bone marrow nuclears under conditions of immobilization stress depends on the type of the hemopoiesis-inducing microenvironment cells and the period of blood system reaction to stress exposure. Secretory activity of monocy...

journal_title：Bulletin of experimental biology and medicine

authors： Miroshnichenko LA,Zhdanov VV,Udut EV,Polyakova TY,Zyuz'kov GN,Simanina EV,Sherstoboev EY,Stavrova LA,Agafonov VI,Minakova MY,Chaikovskii AV,Dygai AM

更新日期：2017-07-01 00:00:00

abstract：:We compared the effects of soluble products from the placenta obtained from women with normal pregnancy and pregnancy complicated by preeclampsia on cytokine secretion by THP-1 cells cultured on a 3D Matrigel scaffold. In the presence of soluble products from all placentas, the cells actively secreted IL-8, MCP-1, and...

journal_title：Bulletin of experimental biology and medicine

authors： Onokhina YS,L'vova TY,Tsitskarava DZ,Koren'kov DA,Sel'kov SA,Sokolov DI

更新日期：2014-02-01 00:00:00

abstract：:We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of ...

journal_title：Bulletin of experimental biology and medicine

authors： Rozenfel'd SV,Togo EF,Mikheev VS,Popovich IG,Zabezhinskii MA,Anisimov VN

更新日期：2001-05-01 00:00:00

abstract：:We studied the neuroprotective effect of a new selective anxiolytic afobazole on rats with bilateral focal ischemic stroke in the prefrontal cortex caused by photothrombosis. Intraperitoneal injection of 5 mg/kg afobazole 1 h after surgery and over the next 8 days (daily treatment) produced a neuroprotective effect. A...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Romanova GA,Shakova FM

更新日期：2008-02-01 00:00:00

abstract：:We propose a noninvasive method of in vivo examination the hemostasis system based on speckle pattern analysis of coherent light scattering from the skin. We compared the results of measuring basic blood coagulation parameters by conventional invasive and noninvasive methods. A strict correlation was found between the...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznik BI,Fine IW,Kaminsky AV

更新日期：2011-09-01 00:00:00

abstract：:Low-dose (250 mg daily) oral probucol produces a significant antioxidant effect in coronary patients: increases activity of glutathione peroxidase (enzyme utilizing lipoperoxides) and reduces the content of free-radical oxidation products in the blood. Probucol therapy for 7 days before and for 6 months after coronary...

journal_title：Bulletin of experimental biology and medicine

authors： Kaminnyi AI,Lankin VZ,Perepelitsa EI,Konovalova GG,Samko AN,Tikhaze AK,Kukharchuk VV,Belenkov YN

更新日期：2007-11-01 00:00:00

abstract：:We studied the course and outcome of pregnancy in the model of inflammation of internal genital organs in female rats. It was shown that inflammation of internal genital organs impairing the state of the lymphatic region of the uterus and adnexa and relationship between the drainage and detoxification function therein...

journal_title：Bulletin of experimental biology and medicine

authors： Dergacheva TI,Borodin YI,Konenkov VI

更新日期：2014-10-01 00:00:00

abstract：:The mechanism of antiischemic effect of low-energy laser radiation was studied in rats with experimental myocardial infarction taking into consideration the effect of laser on hemoglobin affinity for oxygen and intensity of lipid peroxidation. Low-energy laser irradiation for 15 min in vitro decreased the area of myoc...

journal_title：Bulletin of experimental biology and medicine

authors： Gatsura SV,Gladkikh SP,Titov MN

更新日期：2004-04-01 00:00:00

abstract：:We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level ...

journal_title：Bulletin of experimental biology and medicine

authors： Sukhovershin RA,Gilinsky MA

更新日期：2012-08-01 00:00:00

abstract：:Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explain...

journal_title：Bulletin of experimental biology and medicine

authors： Titov VN,Sazhina NN

更新日期：2014-12-01 00:00:00

abstract：:Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before carcinogen challenge reduced the number of lung adenomas caused by it in males and somewhat increased the number of tumors in females. Exogenous testosterone a...

journal_title：Bulletin of experimental biology and medicine

authors： Morozkova TS,Kaledin VI

更新日期：2015-10-01 00:00:00

abstract：:Study was performed by counting cells with chromosomal aberrations in C57Bl/6 mice. Bark dry extract was given perorally in doses of 50, 150, 450, and 1500 mg/kg. Mutagens dioxidine and cyclophosphamide were injected intraperitoneally in doses of 200 and 20 mg/kg, respectively. Bark dry extract in doses of 150 and 150...

journal_title：Bulletin of experimental biology and medicine

authors： Zhanataev AK,Presnova GA,Chistyakov AN,Durnev AD

更新日期：2004-11-01 00:00:00

abstract：:We studied the effects of homeopathic monopreparations of plant origin Atropa Belladonna and Rhus toxicodendron in three dilutions (potencies) on interstitial humoral transport in healthy laboratory mice assessed by the rate of excretion of the lymphotropic label from the mesentery according to the Oyvin's method (vit...

journal_title：Bulletin of experimental biology and medicine

authors： Rodionova OM,Glebov VV,Artamonova EV,Butenin MA,Anikina EV

更新日期：2016-10-01 00:00:00

abstract：:Serum activity of tartrate-resistant acid phosphatase 5b (TRAP 5b) in patients with breast cancer and prostate cancer having bone metastases was much higher than in healthy donors and patients without skeletal injuries. TRAP 5b activity in patients with breast cancer and multiple bone metastases surpassed that in pati...

journal_title：Bulletin of experimental biology and medicine

authors： Lyubimova NV,Pashkov MV,Tyulyandin SA,Gol'dberg VE,Kushlinskii NE

更新日期：2004-07-01 00:00:00

abstract：:Fucoidans isolated from Fucus evanescens and Laminaria cichorioides kelp can inhibit thrombin and factor Xa of the blood coagulation system. In rats, intravenous injection of fucoidans dose-dependently increased anticoagulant activity of the plasma. Fucoidans can form complexes with protamine sulfate. The observed qua...

journal_title：Bulletin of experimental biology and medicine

authors： Drozd NN,Tolstenkov AS,Makarov VA,Kuznetsova TA,Besednova NN,Shevchenko NM,Zvyagintseva TN

更新日期：2006-11-01 00:00:00

abstract：:We studied the effects of chronic administration of granulocyte colony-stimulating factor in nonmobilizing doses to mice. Over 18 months of the study, 55% animals of the treatment group died of unknown cause, blood diseases and tumors were found in 20% mice, and in 5% animals pathological changes were absent. Control ...

journal_title：Bulletin of experimental biology and medicine

authors： Nifontova IN,Svinareva DA,Chertkov IL,Drize NI,Savchenko VG

更新日期：2008-05-01 00:00:00

abstract：:In experiments on Wistar rats we studied the effect of low-frequency electromagnetic field rotating in either right-handed or a left-handed sense on proteolytic activity of pepsin. The right-handed rotating field increased, while left-handed rotating field decreased pepsin activity. Possible mechanisms of these change...

journal_title：Bulletin of experimental biology and medicine

authors： Subbotina TI,Khadartsev AA,Yashin MA,Yashin AA

更新日期：2005-03-01 00:00:00

abstract：:We studied the effects of a concentrate of metabolites of Trichoderma harzianum Rifai F-180, an active producer of L-lysine-α-oxidase, and homogenous enzyme on a highly virulent bacteria Erwinia amylovora. The producer of antitumor and antiviral Trichoderma enzyme L-lysine-α-oxidase was cultured on a processing system...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova IP,Karimova EV,Shneider YA

更新日期：2017-10-01 00:00:00

abstract：:We studied multipotent mesenchymal stromal cells isolated from the bone marrow of young (1 month) and old (>12 months) rats. The cell cultures derived from old rats were characterized by lower cell yield in the primary culture, lower number of doublings, and reduced colony-forming capacity of precursor cells. ...

journal_title：Bulletin of experimental biology and medicine

authors： Valyushina MP,Buravkova LB

更新日期：2013-05-01 00:00:00

abstract：:We studied the effect of UV light (240-390 nm) in doses of 75.5-4530 J/m(2) on functional properties and level of intracellular messengers (cAMP, Ca(2+), NO) in lymphocytic cells of the peripheral blood. Correcting effects of UV light in a dose of 151 J/m(2) on cytotoxic activity of lymphocytes against Ehrlich ascetic...

journal_title：Bulletin of experimental biology and medicine

authors： Nakvasina MA,Lidokhova OV,Popova LI,Trubitsyna MS,Artyukhov VG

更新日期：2011-04-01 00:00:00