Abstract：
:We studied ultrastructural reorganization of the colon transplant in delayed period after esophagoplasty. It was found that during functioning of the artificial esophagus, a complex of adaptive and pathologic processes occurs in the mucosa. Focal sclerosis of the mucosa and slight epithelial degeneration with hyperplasia and hypersecretion of goblet cells were found in biopsy specimens with stenosis of the anastomosis. In case of colonopathy of the transplant, more pronounced epithelial degeneration and proliferation accompanied by abundant polymorphocellular stromal infiltration were seen. Deformation of the transplant was characterized by progressive atrophic and sclerotic reorganization of the mucosa. Goblet cells with ultrastructural signs of hypersecretion predominated in the population of epithelial cells of the colon transplant; oligomucus and poorly differentiated cell and colonocytes with signs of alteration and degenerative changes in cytoplasmic organelles were also found.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Nepomnyashchikh LM,Lapii GA,Chikinev YV,Sudovykh IE,Tokmakov IAdoi
10.1007/s10517-012-1693-9subject
Has Abstractpub_date
2012-06-01 00:00:00pages
269-73issue
2eissn
0007-4888issn
1573-8221journal_volume
153pub_type
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